Mathematical model indicates nonlinearity of noradrenaline effect on rat renal artery
The aim of this work is to present the efficacy of a previously introduced computational procedure, developed for evaluation of vascular responsiveness. On this reason, as an example a common study of noradrenaline (NA) effect on a rat renal artery under in vitro conditions was arbitrarily selected....
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| Veröffentlicht in: | Physiological research 2008-01, Vol.57 (5), p.785-788, Article 785 |
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| creator | Ďurišová, M Dedík, L Kristová, V Vojtko, R |
| description | The aim of this work is to present the efficacy of a previously introduced computational procedure, developed for evaluation of vascular responsiveness. On this reason, as an example a common study of noradrenaline (NA) effect on a rat renal artery under in vitro conditions was arbitrarily selected. The response of the arterial segment to NA doses (0.1-10 microg) was digitally recorded on a PC and employed to develop mathematical model of NA effect. Using the model, the following NA effect variables were determined: the vessel sensitivity parameter, mean effect time and rate constant, respectively, characterizing the effect intensity, duration, and regression and also classic response variables: the maximal effect and time of the maximal effect. The two-way analysis of variance followed by Bonferroni's test revealed a significant influence of the increasing NA dose on the vessel sensitivity parameter and mean effect time. These findings indicated nonlinearity of processes underlying NA effect on the rat renal artery over the given range of NA doses. The procedure exemplified has the potential for use as an effective adjunct to routine studies of vascular responsiveness as it enables the extraction of meaningful information which cannot by obtained by common manual evaluation procedures. |
| doi_str_mv | 10.33549/physiolres.931199 |
| format | Article |
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On this reason, as an example a common study of noradrenaline (NA) effect on a rat renal artery under in vitro conditions was arbitrarily selected. The response of the arterial segment to NA doses (0.1-10 microg) was digitally recorded on a PC and employed to develop mathematical model of NA effect. Using the model, the following NA effect variables were determined: the vessel sensitivity parameter, mean effect time and rate constant, respectively, characterizing the effect intensity, duration, and regression and also classic response variables: the maximal effect and time of the maximal effect. The two-way analysis of variance followed by Bonferroni's test revealed a significant influence of the increasing NA dose on the vessel sensitivity parameter and mean effect time. These findings indicated nonlinearity of processes underlying NA effect on the rat renal artery over the given range of NA doses. The procedure exemplified has the potential for use as an effective adjunct to routine studies of vascular responsiveness as it enables the extraction of meaningful information which cannot by obtained by common manual evaluation procedures.</description><identifier>ISSN: 0862-8408</identifier><identifier>EISSN: 1802-9973</identifier><identifier>DOI: 10.33549/physiolres.931199</identifier><identifier>PMID: 17949245</identifier><language>eng</language><publisher>Czech Republic: Institute of Physiology</publisher><subject>Animals ; Computer Simulation ; Conflicts of interest ; Dose-Response Relationship, Drug ; Male ; Models, Cardiovascular ; Nonlinear Dynamics ; Norepinephrine - pharmacology ; Rats ; Rats, Wistar ; Renal Artery - drug effects ; Time Factors ; Variables ; Vasoconstriction - drug effects ; Vasoconstrictor Agents - pharmacology ; Veins & arteries</subject><ispartof>Physiological research, 2008-01, Vol.57 (5), p.785-788, Article 785</ispartof><rights>Copyright Institute of Physiology 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-e3edac8ef7ab4bc7dfaacb27efca434d8097de28bf04feb3e05fb863cd96c1fd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,861,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17949245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ďurišová, M</creatorcontrib><creatorcontrib>Dedík, L</creatorcontrib><creatorcontrib>Kristová, V</creatorcontrib><creatorcontrib>Vojtko, R</creatorcontrib><title>Mathematical model indicates nonlinearity of noradrenaline effect on rat renal artery</title><title>Physiological research</title><addtitle>Physiol Res</addtitle><description>The aim of this work is to present the efficacy of a previously introduced computational procedure, developed for evaluation of vascular responsiveness. On this reason, as an example a common study of noradrenaline (NA) effect on a rat renal artery under in vitro conditions was arbitrarily selected. The response of the arterial segment to NA doses (0.1-10 microg) was digitally recorded on a PC and employed to develop mathematical model of NA effect. Using the model, the following NA effect variables were determined: the vessel sensitivity parameter, mean effect time and rate constant, respectively, characterizing the effect intensity, duration, and regression and also classic response variables: the maximal effect and time of the maximal effect. The two-way analysis of variance followed by Bonferroni's test revealed a significant influence of the increasing NA dose on the vessel sensitivity parameter and mean effect time. These findings indicated nonlinearity of processes underlying NA effect on the rat renal artery over the given range of NA doses. The procedure exemplified has the potential for use as an effective adjunct to routine studies of vascular responsiveness as it enables the extraction of meaningful information which cannot by obtained by common manual evaluation procedures.</description><subject>Animals</subject><subject>Computer Simulation</subject><subject>Conflicts of interest</subject><subject>Dose-Response Relationship, Drug</subject><subject>Male</subject><subject>Models, Cardiovascular</subject><subject>Nonlinear Dynamics</subject><subject>Norepinephrine - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Renal Artery - drug effects</subject><subject>Time Factors</subject><subject>Variables</subject><subject>Vasoconstriction - drug effects</subject><subject>Vasoconstrictor Agents - pharmacology</subject><subject>Veins & arteries</subject><issn>0862-8408</issn><issn>1802-9973</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kE9LAzEUxIMotla_gAcJ3rdmk-wmOUrxH1S82POSTV5oynZTk_Sw3961LQgePD1mmBkeP4RuSzJnrOLqYbcekg9dhDRXrCyVOkPTUhJaKCXYOZoSWdNCciIn6CqlDSFUEMEu0aQUiivKqylaveu8hq3O3ugOb4OFDvvejipDwn3oO9-Djj4POLhRR20j9PrHxeAcmIxDj6PO-GBjHTPE4RpdON0luDndGVo9P30uXovlx8vb4nFZGCZoLoCB1UaCE7rlrRHWaW1aKsAZzRm3kihhgcrWEe6gZUAq18qaGatqUzrLZuj-uLuL4WsPKTebsI_jH6mhJaWU1XU1hugxZGJIKYJrdtFvdRyakjQHkM0vyOYIcizdnZb37Rbsb-VEbgzIP6vG5xFj6HPUvvtv-xvfkIkP</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Ďurišová, M</creator><creator>Dedík, L</creator><creator>Kristová, V</creator><creator>Vojtko, R</creator><general>Institute of Physiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>20080101</creationdate><title>Mathematical model indicates nonlinearity of noradrenaline effect on rat renal artery</title><author>Ďurišová, M ; 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On this reason, as an example a common study of noradrenaline (NA) effect on a rat renal artery under in vitro conditions was arbitrarily selected. The response of the arterial segment to NA doses (0.1-10 microg) was digitally recorded on a PC and employed to develop mathematical model of NA effect. Using the model, the following NA effect variables were determined: the vessel sensitivity parameter, mean effect time and rate constant, respectively, characterizing the effect intensity, duration, and regression and also classic response variables: the maximal effect and time of the maximal effect. The two-way analysis of variance followed by Bonferroni's test revealed a significant influence of the increasing NA dose on the vessel sensitivity parameter and mean effect time. These findings indicated nonlinearity of processes underlying NA effect on the rat renal artery over the given range of NA doses. The procedure exemplified has the potential for use as an effective adjunct to routine studies of vascular responsiveness as it enables the extraction of meaningful information which cannot by obtained by common manual evaluation procedures.</abstract><cop>Czech Republic</cop><pub>Institute of Physiology</pub><pmid>17949245</pmid><doi>10.33549/physiolres.931199</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Computer Simulation Conflicts of interest Dose-Response Relationship, Drug Male Models, Cardiovascular Nonlinear Dynamics Norepinephrine - pharmacology Rats Rats, Wistar Renal Artery - drug effects Time Factors Variables Vasoconstriction - drug effects Vasoconstrictor Agents - pharmacology Veins & arteries |
| title | Mathematical model indicates nonlinearity of noradrenaline effect on rat renal artery |
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