Prenylated Xanthone and Rubraxanthone with Antiplatelet Aggregation Activity in Human Whole Blood Isolated from Garcinia griffithii
Phytochemical studies on the methanolic extract of the leaves of Garcinia griffithii (Guttiferae) afforded two known xanthones derivatives, 1,3,5,6-Tetrahydroxy-7-(3-methylbut-2-enyl)xanthone (1) and Rubraxanthone (2). The structures of these xanthones derivatives were determined on the basis of ext...
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| Veröffentlicht in: | Oriental journal of chemistry 2013, Vol.29 (4), p.1291-1295 |
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| container_title | Oriental journal of chemistry |
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| creator | Alkadi, Khaled Adam, Aishah Taha, Muhammad Hasan, Mizaton Shah, Syed |
| description | Phytochemical studies on the methanolic extract of the leaves of Garcinia griffithii (Guttiferae) afforded two known xanthones derivatives, 1,3,5,6-Tetrahydroxy-7-(3-methylbut-2-enyl)xanthone (1) and Rubraxanthone (2). The structures of these xanthones derivatives were determined on the basis of extensive spectroscopic data interpretation and comparison with data reported in the literature. In an in vitro test, compound 1 and 2 showed the ability to inhibit platelet aggregation in human whole blood which induced by arachidonic acid (AA), adenosine diphosphate (ADP) and collagen. |
| doi_str_mv | 10.13005/ojc/290404 |
| format | Article |
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The structures of these xanthones derivatives were determined on the basis of extensive spectroscopic data interpretation and comparison with data reported in the literature. In an in vitro test, compound 1 and 2 showed the ability to inhibit platelet aggregation in human whole blood which induced by arachidonic acid (AA), adenosine diphosphate (ADP) and collagen.</description><identifier>ISSN: 0970-020X</identifier><identifier>EISSN: 2231-5039</identifier><identifier>DOI: 10.13005/ojc/290404</identifier><language>eng</language><publisher>Bhopal: Oriental Scientific Publishing Company</publisher><subject>Adenosine diphosphate ; Agglomeration ; Arachidonic acid ; Blood platelets ; Chromatography ; Collagen ; Derivatives ; Flavonoids ; In vitro methods and tests ; Investigations ; Leaves ; Metabolites ; Natural products ; Pharmaceutical industry ; Phytochemicals ; Variance analysis</subject><ispartof>Oriental journal of chemistry, 2013, Vol.29 (4), p.1291-1295</ispartof><rights>2013. 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| ispartof | Oriental journal of chemistry, 2013, Vol.29 (4), p.1291-1295 |
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| source | Full-Text Journals in Chemistry (Open access); EZB Electronic Journals Library |
| subjects | Adenosine diphosphate Agglomeration Arachidonic acid Blood platelets Chromatography Collagen Derivatives Flavonoids In vitro methods and tests Investigations Leaves Metabolites Natural products Pharmaceutical industry Phytochemicals Variance analysis |
| title | Prenylated Xanthone and Rubraxanthone with Antiplatelet Aggregation Activity in Human Whole Blood Isolated from Garcinia griffithii |
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