Antimicrobial Activity and Microbial Transformation of Ethyl p-Methoxycinnamate Extracted from Kaempferia galanga
Ethyl p-methoxycinnamate (EPMC), a major constituent of the Kaempferia galanga rhizome, was transformed to ethyl p-hydroxycinnamate (EPHC) using Aspergillus niger. The EPHC metabolite was elucidated by NMR spectroscopic technique. Antimicrobial microbial study found that EPHC was active against all...
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| Veröffentlicht in: | Oriental journal of chemistry 2014, Vol.30 (3), p.1037-1043 |
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| container_title | Oriental journal of chemistry |
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| creator | Omar, Muhammad Hasali, Nor Alfarra, Helmi Yarmo, Mohd Zuberdi, Ahmad |
| description | Ethyl p-methoxycinnamate (EPMC), a major constituent of the Kaempferia galanga rhizome, was transformed to ethyl p-hydroxycinnamate (EPHC) using Aspergillus niger. The EPHC metabolite was elucidated by NMR spectroscopic technique. Antimicrobial microbial study found that EPHC was active against all strains tested with a good minimum inhibitory concentration (MIC). It was active against both Staphylococcus aureus and Bacillus cereus at MIC 333 µg/ml while against Pseudomonas aeruginosa, Escherichia coli and Candida albicans at MIC 111 µg/ml. It was also shown that EPHC exhibited more growth inhibition potential than EPMC. Besides that, EPHC has shown the minimum bactericidal concentration (MBC) toward B. cereus, P. aeruginosa and E. coli at the concentration of 1000 µg/mL while EPMC did not show killing potential toward the tested microorganisms. |
| doi_str_mv | 10.13005/ojc/300315 |
| format | Article |
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| subjects | Antiinfectives and antibacterials Antimicrobial agents Biological activity Chromatography E coli Flowers & plants Fungi Herbal medicine Microorganisms NMR Nuclear magnetic resonance Oils & fats Pseudomonas aeruginosa |
| title | Antimicrobial Activity and Microbial Transformation of Ethyl p-Methoxycinnamate Extracted from Kaempferia galanga |
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