Synthesis of Some Pyrazolone Derivatives and Evaluation of its Antibacterial and Cytotoxic Activity
A series of novel pyrazolone derivative were synthesized by two different schemes (scheme-1 by the reaction of phenyl hydrazine and ethyl acetoacetate with substituted benzaldehydes PYR-1 to PYR-4) and (by the reaction of synthesized chalcone with phenyl hydrazine PYR-5) and characterised with its p...
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| Veröffentlicht in: | Oriental journal of chemistry 2015, Vol.31 (4), p.2099-2106 |
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| container_issue | 4 |
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| container_title | Oriental journal of chemistry |
| container_volume | 31 |
| creator | Prajuli, Rishiram Banerjee, Janmajoy Khanal, Hemant |
| description | A series of novel pyrazolone derivative were synthesized by two different schemes (scheme-1 by the reaction of phenyl hydrazine and ethyl acetoacetate with substituted benzaldehydes PYR-1 to PYR-4) and (by the reaction of synthesized chalcone with phenyl hydrazine PYR-5) and characterised with its physical parameters (M.P, colour, %yield, solubility etc.). The entire synthesized compound was tested for their antimicrobial activity against Gram-positive and Gram-negative strains of bacteria and brimeshrimp bioassay was conducted for evaluation of cytotoxic activity The Investigation of antimicrobial screening data revealed that most of the tested compounds showed moderate to good antimicrobial activity. And cytotoxicity activity of compounds was also found to be satisfactory. |
| doi_str_mv | 10.13005/ojc/310430 |
| format | Article |
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The entire synthesized compound was tested for their antimicrobial activity against Gram-positive and Gram-negative strains of bacteria and brimeshrimp bioassay was conducted for evaluation of cytotoxic activity The Investigation of antimicrobial screening data revealed that most of the tested compounds showed moderate to good antimicrobial activity. And cytotoxicity activity of compounds was also found to be satisfactory.</description><identifier>ISSN: 0970-020X</identifier><identifier>EISSN: 2231-5039</identifier><identifier>DOI: 10.13005/ojc/310430</identifier><language>eng</language><publisher>Bhopal: Oriental Scientific Publishing Company</publisher><subject>Antimicrobial agents ; Antioxidants ; Biological activity ; Caustic soda ; Chemical synthesis ; Chemistry ; Cytotoxicity ; Ethanol ; Hydrazines ; Pharmacy ; Physical properties ; Pyrazolones ; Toxicity</subject><ispartof>Oriental journal of chemistry, 2015, Vol.31 (4), p.2099-2106</ispartof><rights>2015. 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The entire synthesized compound was tested for their antimicrobial activity against Gram-positive and Gram-negative strains of bacteria and brimeshrimp bioassay was conducted for evaluation of cytotoxic activity The Investigation of antimicrobial screening data revealed that most of the tested compounds showed moderate to good antimicrobial activity. 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| ispartof | Oriental journal of chemistry, 2015, Vol.31 (4), p.2099-2106 |
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| subjects | Antimicrobial agents Antioxidants Biological activity Caustic soda Chemical synthesis Chemistry Cytotoxicity Ethanol Hydrazines Pharmacy Physical properties Pyrazolones Toxicity |
| title | Synthesis of Some Pyrazolone Derivatives and Evaluation of its Antibacterial and Cytotoxic Activity |
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