Facile Synthesis, Characterization and Antimicrobial Activity of 2-Alkanamino Benzimidazole Derivatives
Benzimidazole derivatives are known to represent a class of medicinally important compounds which are extensively used in drug design and catalysis. A series of 2-substituted benzimidazole derivatives 10a-i was herein synthesized from the reaction of o-phenylenediamine with some amino acids using am...
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| Veröffentlicht in: | Oriental journal of chemistry 2016, Vol.32 (1), p.109-120 |
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| container_title | Oriental journal of chemistry |
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| creator | Ajani, Olayinka Aderohunmu, Damilola Olorunshola, Shade Ikpo, Chinwe Olanrewaju, Ifedolapo |
| description | Benzimidazole derivatives are known to represent a class of medicinally important compounds which are extensively used in drug design and catalysis. A series of 2-substituted benzimidazole derivatives 10a-i was herein synthesized from the reaction of o-phenylenediamine with some amino acids using ameliorable pathway. The chemical structures of the synthesized compounds were confirmed by IR, UV, 1H-NMR, 13C-NMR, Mass spectral and analytical data. The compounds were investigated for their antimicrobial activity alongside gentamicin clinical standard. The results showed that this skeletal framework exhibited marked potency as antimicrobial agents. The most active compound was 1H-benzo[d]imidazol-2-yl)methanamine, 10a. |
| doi_str_mv | 10.13005/ojc/320111 |
| format | Article |
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A series of 2-substituted benzimidazole derivatives 10a-i was herein synthesized from the reaction of o-phenylenediamine with some amino acids using ameliorable pathway. The chemical structures of the synthesized compounds were confirmed by IR, UV, 1H-NMR, 13C-NMR, Mass spectral and analytical data. The compounds were investigated for their antimicrobial activity alongside gentamicin clinical standard. The results showed that this skeletal framework exhibited marked potency as antimicrobial agents. 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| subjects | Amino acids Antiinfectives and antibacterials Catalysis Chemical synthesis Chemistry Derivatives NMR Nuclear magnetic resonance Organic chemistry Peptides Pharmaceutical sciences Phenylenediamine |
| title | Facile Synthesis, Characterization and Antimicrobial Activity of 2-Alkanamino Benzimidazole Derivatives |
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