Bacterial microbots for acid-labile release of hybrid micelles to promote the synergistic antitumor efficacy

[Display omitted] Bacteria have inherent properties of self-propelled navigation and specific infiltration into solid tumors. In the current study, we investigate a novel type of bacterial microbots for delivery of hybrid micelles to promote the synergistic antitumor efficacy. Escherichia coli Nissl...

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Veröffentlicht in:	Acta biomaterialia 2018-09, Vol.78, p.198-210
Hauptverfasser:	Xie, Songzhi, Chen, Maohua, Song, Xiaojie, Zhang, Zhao, Zhang, Zhanlin, Chen, Zhoujiang, Li, Xiaohong
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Acids Acids - chemistry Anhydrides Animals Anticancer properties Antineoplastic Agents - pharmacology Antitumor activity Apoptosis Bacteria Bacterial microbot Bioorthogonal reaction Cancer Cell Death - drug effects Cell Line, Tumor Chemical compounds Chemotherapy Copolymers Doxorubicin Drug delivery Drug delivery systems Drug Synergism E coli Effectiveness Escherichia coli Escherichia coli - metabolism Evaporation Female Glutathione Graft copolymers Humans Hybrid micelle Hydrogen-Ion Concentration Infiltration Intracellular Metastases Mice, Inbred BALB C Micelles Microbots Microrobots Mitochondria Nanoparticles Navigation behavior Neoplasms - pathology Pharmacology Polyethylene glycol Polymers Solid tumors Synergistic efficacy Tissue Distribution Toxicity Tumor accumulation Tumor cells Tumors Viability
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