Curcumin incorporated PVA‐borax dual delivery hydrogels as potential wound dressing materials—Correlation between viscoelastic properties and curcumin release rate
ABSTRACT Poly(vinyl alcohol) (PVA) is a biocompatible polymer which can be physically crosslinked by Borax to form hydrogel. PVA‐Borax (PB) hydrogel is a promising candidate for drug delivery system. Therefore, it is necessary to find the quantitative relationship between drug release rate and netwo...
Gespeichert in:
| Veröffentlicht in: | Journal of applied polymer science 2018-12, Vol.135 (45), p.n/a |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | n/a |
|---|---|
| container_issue | 45 |
| container_start_page | |
| container_title | Journal of applied polymer science |
| container_volume | 135 |
| creator | Rezvan, Gelareh Pircheraghi, Gholamreza Bagheri, Reza |
| description | ABSTRACT
Poly(vinyl alcohol) (PVA) is a biocompatible polymer which can be physically crosslinked by Borax to form hydrogel. PVA‐Borax (PB) hydrogel is a promising candidate for drug delivery system. Therefore, it is necessary to find the quantitative relationship between drug release rate and network structure of PB hydrogels to predict and control drug release rate. In this work, at first step the optimum ratio of Borax: PVA was determined by studying the interactions between PVA chains and Borax molecules by means of Fourier transform infrared spectroscopy, while viscoelastic properties of prepared PB hydrogels were measured in the oscillatory shear flow field. In the following, curcumin as a hydrophobic drug was encapsulated in Pluronic F127 micelles and then these nano carriers (Cur‐P) were loaded into prepared hydrogels. The curcumin release rate in PBS solution was investigated by UV–vis spectroscopy measurements. The strong power law correlation between curcumin release rate and viscoelastic properties of PB hydrogel was confirmed. This drug delivery vehicle can be used as a competent wound dress. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46734. |
| doi_str_mv | 10.1002/app.46734 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2121571926</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2121571926</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3154-6f1dd0219399ae81dfcf5ab2bce33ddd86ee8a8d9b28a8803da928ab590b58d3</originalsourceid><addsrcrecordid>eNp1kU1OwzAQhS0EEqWw4AaWWLFIa-ev8bKq-JMq0UXFNnLsSXGVxsFOWrrrEVhwB-7VkzClsGQ19sw3z896hFxzNuCMhUPZNIM4HUXxCelxJkZBnIbZKenhjAeZEMk5ufB-yRjnCUt75GvSOdWtTE1NraxrrJMtaDp7Ge93HwXe3qnuZEU1VGYNbktft9rZBVSeSk8b20LdGpxvbFdrqh14b-oFXaGKw77f7z4n1jmoZGtsTQtoNwA1XRuvLDZ9axRtnG3AtQZQE0XUnyPcAumBHixdkrMS5eDqt_bJ_P5uPnkMps8PT5PxNFART-IgLbnW-FURCSEh47pUZSKLsFAQRVrrLAXIZKZFEWLJWKSlwFORCFYkmY765OYoi57eOvBtvrSdq_HFPOQhT0ZchClSt0dKOeu9gzJvnFlJt805yw8x5BhD_hMDssMjuzEVbP8H8_Fsdtz4BvV_kZc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2121571926</pqid></control><display><type>article</type><title>Curcumin incorporated PVA‐borax dual delivery hydrogels as potential wound dressing materials—Correlation between viscoelastic properties and curcumin release rate</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Rezvan, Gelareh ; Pircheraghi, Gholamreza ; Bagheri, Reza</creator><creatorcontrib>Rezvan, Gelareh ; Pircheraghi, Gholamreza ; Bagheri, Reza</creatorcontrib><description>ABSTRACT
Poly(vinyl alcohol) (PVA) is a biocompatible polymer which can be physically crosslinked by Borax to form hydrogel. PVA‐Borax (PB) hydrogel is a promising candidate for drug delivery system. Therefore, it is necessary to find the quantitative relationship between drug release rate and network structure of PB hydrogels to predict and control drug release rate. In this work, at first step the optimum ratio of Borax: PVA was determined by studying the interactions between PVA chains and Borax molecules by means of Fourier transform infrared spectroscopy, while viscoelastic properties of prepared PB hydrogels were measured in the oscillatory shear flow field. In the following, curcumin as a hydrophobic drug was encapsulated in Pluronic F127 micelles and then these nano carriers (Cur‐P) were loaded into prepared hydrogels. The curcumin release rate in PBS solution was investigated by UV–vis spectroscopy measurements. The strong power law correlation between curcumin release rate and viscoelastic properties of PB hydrogel was confirmed. This drug delivery vehicle can be used as a competent wound dress. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46734.</description><identifier>ISSN: 0021-8995</identifier><identifier>EISSN: 1097-4628</identifier><identifier>DOI: 10.1002/app.46734</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc</publisher><subject>Biocompatibility ; Borax ; Correlation analysis ; Crosslinking ; Drug delivery systems ; Fourier transforms ; hydrogel ; Hydrogels ; Materials science ; Micelles ; Poloxamers ; Polymers ; Properties (attributes) ; rheology ; Shear flow ; Silicon ; Spectrum analysis ; structure‐property relationships ; Viscoelasticity ; Wound healing</subject><ispartof>Journal of applied polymer science, 2018-12, Vol.135 (45), p.n/a</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3154-6f1dd0219399ae81dfcf5ab2bce33ddd86ee8a8d9b28a8803da928ab590b58d3</citedby><cites>FETCH-LOGICAL-c3154-6f1dd0219399ae81dfcf5ab2bce33ddd86ee8a8d9b28a8803da928ab590b58d3</cites><orcidid>0000-0002-5203-6801</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fapp.46734$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fapp.46734$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Rezvan, Gelareh</creatorcontrib><creatorcontrib>Pircheraghi, Gholamreza</creatorcontrib><creatorcontrib>Bagheri, Reza</creatorcontrib><title>Curcumin incorporated PVA‐borax dual delivery hydrogels as potential wound dressing materials—Correlation between viscoelastic properties and curcumin release rate</title><title>Journal of applied polymer science</title><description>ABSTRACT
Poly(vinyl alcohol) (PVA) is a biocompatible polymer which can be physically crosslinked by Borax to form hydrogel. PVA‐Borax (PB) hydrogel is a promising candidate for drug delivery system. Therefore, it is necessary to find the quantitative relationship between drug release rate and network structure of PB hydrogels to predict and control drug release rate. In this work, at first step the optimum ratio of Borax: PVA was determined by studying the interactions between PVA chains and Borax molecules by means of Fourier transform infrared spectroscopy, while viscoelastic properties of prepared PB hydrogels were measured in the oscillatory shear flow field. In the following, curcumin as a hydrophobic drug was encapsulated in Pluronic F127 micelles and then these nano carriers (Cur‐P) were loaded into prepared hydrogels. The curcumin release rate in PBS solution was investigated by UV–vis spectroscopy measurements. The strong power law correlation between curcumin release rate and viscoelastic properties of PB hydrogel was confirmed. This drug delivery vehicle can be used as a competent wound dress. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46734.</description><subject>Biocompatibility</subject><subject>Borax</subject><subject>Correlation analysis</subject><subject>Crosslinking</subject><subject>Drug delivery systems</subject><subject>Fourier transforms</subject><subject>hydrogel</subject><subject>Hydrogels</subject><subject>Materials science</subject><subject>Micelles</subject><subject>Poloxamers</subject><subject>Polymers</subject><subject>Properties (attributes)</subject><subject>rheology</subject><subject>Shear flow</subject><subject>Silicon</subject><subject>Spectrum analysis</subject><subject>structure‐property relationships</subject><subject>Viscoelasticity</subject><subject>Wound healing</subject><issn>0021-8995</issn><issn>1097-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kU1OwzAQhS0EEqWw4AaWWLFIa-ev8bKq-JMq0UXFNnLsSXGVxsFOWrrrEVhwB-7VkzClsGQ19sw3z896hFxzNuCMhUPZNIM4HUXxCelxJkZBnIbZKenhjAeZEMk5ufB-yRjnCUt75GvSOdWtTE1NraxrrJMtaDp7Ge93HwXe3qnuZEU1VGYNbktft9rZBVSeSk8b20LdGpxvbFdrqh14b-oFXaGKw77f7z4n1jmoZGtsTQtoNwA1XRuvLDZ9axRtnG3AtQZQE0XUnyPcAumBHixdkrMS5eDqt_bJ_P5uPnkMps8PT5PxNFART-IgLbnW-FURCSEh47pUZSKLsFAQRVrrLAXIZKZFEWLJWKSlwFORCFYkmY765OYoi57eOvBtvrSdq_HFPOQhT0ZchClSt0dKOeu9gzJvnFlJt805yw8x5BhD_hMDssMjuzEVbP8H8_Fsdtz4BvV_kZc</recordid><startdate>20181205</startdate><enddate>20181205</enddate><creator>Rezvan, Gelareh</creator><creator>Pircheraghi, Gholamreza</creator><creator>Bagheri, Reza</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><orcidid>https://orcid.org/0000-0002-5203-6801</orcidid></search><sort><creationdate>20181205</creationdate><title>Curcumin incorporated PVA‐borax dual delivery hydrogels as potential wound dressing materials—Correlation between viscoelastic properties and curcumin release rate</title><author>Rezvan, Gelareh ; Pircheraghi, Gholamreza ; Bagheri, Reza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3154-6f1dd0219399ae81dfcf5ab2bce33ddd86ee8a8d9b28a8803da928ab590b58d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Biocompatibility</topic><topic>Borax</topic><topic>Correlation analysis</topic><topic>Crosslinking</topic><topic>Drug delivery systems</topic><topic>Fourier transforms</topic><topic>hydrogel</topic><topic>Hydrogels</topic><topic>Materials science</topic><topic>Micelles</topic><topic>Poloxamers</topic><topic>Polymers</topic><topic>Properties (attributes)</topic><topic>rheology</topic><topic>Shear flow</topic><topic>Silicon</topic><topic>Spectrum analysis</topic><topic>structure‐property relationships</topic><topic>Viscoelasticity</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rezvan, Gelareh</creatorcontrib><creatorcontrib>Pircheraghi, Gholamreza</creatorcontrib><creatorcontrib>Bagheri, Reza</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Journal of applied polymer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rezvan, Gelareh</au><au>Pircheraghi, Gholamreza</au><au>Bagheri, Reza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Curcumin incorporated PVA‐borax dual delivery hydrogels as potential wound dressing materials—Correlation between viscoelastic properties and curcumin release rate</atitle><jtitle>Journal of applied polymer science</jtitle><date>2018-12-05</date><risdate>2018</risdate><volume>135</volume><issue>45</issue><epage>n/a</epage><issn>0021-8995</issn><eissn>1097-4628</eissn><abstract>ABSTRACT
Poly(vinyl alcohol) (PVA) is a biocompatible polymer which can be physically crosslinked by Borax to form hydrogel. PVA‐Borax (PB) hydrogel is a promising candidate for drug delivery system. Therefore, it is necessary to find the quantitative relationship between drug release rate and network structure of PB hydrogels to predict and control drug release rate. In this work, at first step the optimum ratio of Borax: PVA was determined by studying the interactions between PVA chains and Borax molecules by means of Fourier transform infrared spectroscopy, while viscoelastic properties of prepared PB hydrogels were measured in the oscillatory shear flow field. In the following, curcumin as a hydrophobic drug was encapsulated in Pluronic F127 micelles and then these nano carriers (Cur‐P) were loaded into prepared hydrogels. The curcumin release rate in PBS solution was investigated by UV–vis spectroscopy measurements. The strong power law correlation between curcumin release rate and viscoelastic properties of PB hydrogel was confirmed. This drug delivery vehicle can be used as a competent wound dress. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46734.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/app.46734</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-5203-6801</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8995 |
| ispartof | Journal of applied polymer science, 2018-12, Vol.135 (45), p.n/a |
| issn | 0021-8995 1097-4628 |
| language | eng |
| recordid | cdi_proquest_journals_2121571926 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Biocompatibility Borax Correlation analysis Crosslinking Drug delivery systems Fourier transforms hydrogel Hydrogels Materials science Micelles Poloxamers Polymers Properties (attributes) rheology Shear flow Silicon Spectrum analysis structure‐property relationships Viscoelasticity Wound healing |
| title | Curcumin incorporated PVA‐borax dual delivery hydrogels as potential wound dressing materials—Correlation between viscoelastic properties and curcumin release rate |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T01%3A32%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Curcumin%20incorporated%20PVA%E2%80%90borax%20dual%20delivery%20hydrogels%20as%20potential%20wound%20dressing%20materials%E2%80%94Correlation%20between%20viscoelastic%20properties%20and%20curcumin%20release%20rate&rft.jtitle=Journal%20of%20applied%20polymer%20science&rft.au=Rezvan,%20Gelareh&rft.date=2018-12-05&rft.volume=135&rft.issue=45&rft.epage=n/a&rft.issn=0021-8995&rft.eissn=1097-4628&rft_id=info:doi/10.1002/app.46734&rft_dat=%3Cproquest_cross%3E2121571926%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2121571926&rft_id=info:pmid/&rfr_iscdi=true |