Succinate is the controller of O2−/H2O2 release at mitochondrial complex I : negative modulation by malate, positive by cyanide

Mitochondrial production of H 2 O 2 is low with NAD substrates (glutamate/pyruvate, 3 and 2 mM) (G/P) and increases over ten times upon further addition of succinate, with the formation of a sigmoidal curve (semimaximal value at 290 µM, maximal H 2 O 2 production at 600 µM succinate). Malate counter...

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