Molecular docking study and structure‐based design of novel camptothecin analogues used as topoisomerase I inhibitor

The paper describes the molecular docking study of the inhibition of human topoisomerase I (Top1), which is the molecular target of a diverse set of anticancer compounds such as glycinate, camptothecin, and its analogues. The reaction mechanisms involving their interaction with a transient Top1–DNA...

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Veröffentlicht in:	Journal of the Chinese Chemical Society (Taipei) 2018-10, Vol.65 (10), p.1160-1178
Hauptverfasser:	Arthur, David Ebuka, Uzairu, Adamu
Format:	Artikel
Sprache:	eng
Schlagworte:	camptothecin Coordination compounds Deoxyribonucleic acid DNA Fragments inhibition constant intercalation Molecular docking Molecular structure Pi–Pi interaction Reaction mechanisms topoisomerase
Online-Zugang:	Volltext
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