Effects of aloe emodin on U87MG glioblastoma cell growth: In vitro and in vivo study

Glioblastoma, the most aggressive and malignant form of glioma, appears to be resistant to various chemotherapeutic agents. Hence other approaches have been investigated to target more pathways involved in glioblastoma development and progression. Here we investigate the anticancer effect of Aloe‐Em...

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Veröffentlicht in:	Environmental toxicology 2018-11, Vol.33 (11), p.1160-1167
Hauptverfasser:	Arcella, Antonietta, Oliva, Maria Antonietta, Staffieri, Sabrina, Sanchez, Massimo, Madonna, Michele, Riozzi, Barbara, Esposito, Vincenzo, Giangaspero, Felice, Frati, Luigi
Format:	Artikel
Sprache:	eng
Schlagworte:	adjuvant chemotherapy Adult Aloe aloe emodin Animals Anthraquinone Anthraquinones - pharmacology Anticancer properties Antitumour agents Apoptosis Apoptosis - drug effects Biocompatibility Brain cancer Brain Neoplasms - drug therapy Brain Neoplasms - pathology Cell cycle Cell Cycle - drug effects Cell Division - drug effects Cell growth Cell Proliferation - drug effects Chemotherapy Emodin Flow cytometry G2 Phase - drug effects Glioblastoma Glioblastoma - drug therapy Glioblastoma - pathology Glioma Humans In vivo methods and tests Inhibition Male Mice Mice, Nude natural drug Phosphorylation Poly(ADP-ribose) polymerase Proliferation Severe combined immunodeficiency Shrinkage temozolomide Time dependence Toxicity Tumor Cells, Cultured Xenograft Model Antitumor Assays
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