Chronic chromium exposure-induced changes in testicular histoarchitecture are associated with oxidative stress: study in a non-human primate (Macaca radiata Geoffroy)

BACKGROUND: Reproductive toxicity of chromium is in dispute despite positive findings in rodents. Recently we reported epididymal toxicity of hexavalent chromium (CrVI) in bonnet monkeys and in this paper we report its testicular toxicity. METHODS: Adult monkeys (Macaca radiata) were given drinking...

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Veröffentlicht in:	Human reproduction (Oxford) 2005-10, Vol.20 (10), p.2801-2813
Hauptverfasser:	Aruldhas, M. Michael, Subramanian, S., Sekar, P., Vengatesh, G., Chandrahasan, Gowri, Govindarajulu, P., Akbarsha, M.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - chemistry Antioxidants - metabolism Antioxidants - pharmacology Ascorbic Acid - metabolism Biological and medical sciences Catalase - metabolism Chromatin - chemistry Chromatin - metabolism chromium Chromium - chemistry Chromium - pharmacology Chromium - toxicity Cytoplasm - metabolism Free Radicals Glucosephosphate Dehydrogenase - metabolism Glutathione - chemistry Glutathione - metabolism Glutathione Peroxidase - metabolism Glutathione Reductase - metabolism Golgi Apparatus - metabolism Gynecology. Andrology. Obstetrics Hydrogen Peroxide - pharmacology Hydroxyl Radical Macaca radiata Macrophages - metabolism Male Medical sciences Microscopy, Electron, Transmission multinucleate spermatids Necrosis Oxidative Stress Phagocytosis Reactive Oxygen Species Sertoli Cells - metabolism Spermatids - metabolism Spermatocytes - metabolism Superoxide Dismutase - metabolism testicular toxicity Testis - drug effects Testis - pathology Testis - ultrastructure Time Factors Vacuoles - metabolism Vitamin A - metabolism Vitamin E - metabolism
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