Mitochondrial damage in patients with long-term corticosteroid therapy: development of oculoskeletal symptoms similar to mitochondrial disease

Two patients with long-term corticosteroid administration sporadically developed limb muscle wasting followed by ophthalmoplegia, and the skeletal muscle pathology revealed ragged-red fibers (RRFs) with abnormal mitochondria, in addition to the findings of corticosteroid myopathy. The oculoskeletal...

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Veröffentlicht in:	Acta neuropathologica 2002-09, Vol.104 (3), p.260-266
Hauptverfasser:	MITSUI, Takao, UMAKI, Yoshifumi, NAGASAWA, Masakazu, AKAIKE, Masashi, AKI, Kenji, AZUMA, Hiroyuki, OZAKI, Shyuji, ODOMI, Masaaki, MATSUMOTO, Toshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes - metabolism Anti-Inflammatory Agents - adverse effects Biological and medical sciences Deoxyguanosine - analogs & derivatives Deoxyguanosine - metabolism Diagnosis, Differential Drug toxicity and drugs side effects treatment Exercise Test Female Gene Deletion Humans Lactic Acid - blood Male Medical sciences Middle Aged Mitochondria, Muscle - metabolism Mitochondria, Muscle - pathology Oculomotor Muscles - enzymology Oculomotor Muscles - pathology Oculomotor Muscles - physiopathology Ophthalmoplegia, Chronic Progressive External - chemically induced Ophthalmoplegia, Chronic Progressive External - enzymology Ophthalmoplegia, Chronic Progressive External - physiopathology Pharmacology. Drug treatments Prednisolone - adverse effects Superoxide Dismutase - metabolism Time Factors Toxicity: eye
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