Effects of l‐arginine and sodium nitroprusside on the spontaneous contractility of human non‐pregnant uterus

BACKGROUND: The aim of this study was to investigate, in isolated human non‐gravid myometrium, the involvement of the cyclic guanosine monophosphate (cGMP) pathway in nitric oxide (NO) induced relaxation. METHODS: Strips of human myometrium from hysterectomized women were suspended in organ baths fo...

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Veröffentlicht in:	Human reproduction (Oxford) 2003-01, Vol.18 (1), p.148-151
Hauptverfasser:	Hoffmann, P., Stanke‐Labesque, F., Fanchin, R., Dilaï, N., Pons, J.C., Ayoubi, J.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Arginine - administration & dosage Arginine - pharmacology Biological and medical sciences Cyclic GMP - analogs & derivatives Cyclic GMP - pharmacology Dose-Response Relationship, Drug Drug Synergism Female Fundamental and applied biological sciences. Psychology Humans In Vitro Techniques Key words: cGMP pathway/human non‐pregnant uterus/methylene blue/nitric oxide Mammalian female genital system Methylene Blue - pharmacology Middle Aged Morphology. Physiology Nitric Oxide Donors - pharmacology Nitroprusside - pharmacology Osmolar Concentration Uterine Contraction - drug effects Uterus - drug effects Vertebrates: reproduction
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