Dopaminergic neurotoxic effects of 3-TFMPP derivatives

Designer drugs are synthetically formulated to mimic the psychostimulatory effects of an original controlled/illegal drug of abuse. Designer drugs have similar chemical structure or functional analog as compared to existing controlled psychostimulatory drugs. There is a substantial rise in the produ...

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Veröffentlicht in:	Life sciences (1973) 2018-09, Vol.209, p.357-369
Hauptverfasser:	Majrashi, Mohammed, Almaghrabi, Mohammed, Fadan, Maali, Fujihashi, Ayaka, Lee, Wooseok, Deruiter, Jack, Randall Clark, C., Dhanasekaran, Muralikrishnan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Cells, Cultured Congeners Derivatives Designer drugs Dopamine Dopamine - metabolism Dopamine receptors Dopaminergic Neurons - drug effects Dopaminergic Neurons - metabolism Dopaminergic Neurons - pathology Drug abuse Drugs Hydroxylase Law enforcement Lethality Liability MDMA Mechanisms of toxicity Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondria - pathology Neurotoxicity Neurotoxicity Syndromes - etiology Neurotoxicity Syndromes - metabolism Neurotoxicity Syndromes - pathology Organic chemicals Organic chemistry Oxidative stress Oxidative Stress - drug effects Piperazine Piperazines Piperazines - chemistry Piperazines - toxicity Psychostimulants Psychotropic drugs Rats Serotonin Receptor Agonists - chemistry Serotonin Receptor Agonists - toxicity Time dependence Tyrosine Tyrosine 3-monooxygenase Tyrosine 3-Monooxygenase - metabolism
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