Can HBsAg Be Used as a Viral Replication Marker in Chronic Hepatitis B Patients?
Objective: Monitoring hepatitis B virus (HBV) treatment responses and virus replication is performed with molecular tests. However, these tests are either expensive or invasive. A new and more practical marker is needed. We aimed to evaluate the correlation between serum hepatitis B surface antigen...
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| Veröffentlicht in: | Viral Hepatit Dergisi 2017-08, Vol.23 (2), p.55-59 |
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| creator | UZUNOĞLU, Emel ŞAHİN, Ahmet Melih AVCI, Esin KUTLU, Hakan GÜNTEPE, Gökçe |
| description | Objective: Monitoring hepatitis B virus (HBV) treatment responses and virus replication is performed with molecular tests. However, these tests are either expensive or invasive. A new and more practical marker is needed. We aimed to evaluate the correlation between serum hepatitis B surface antigen (HBsAg) and alanine aminotransferase (ALT) levels and HBV DNA level in hepatitis B e antigen (HBeAg) +/- patients and detect whether HBsAg can be used as a surrogate replication marker instead of HBV DNA.
Material and Methods: A retrospective study was conducted in 59 chronic hepatitis B patients. Serum ALT, HBsAg and HBeAg levels and HBV DNA levels were recorded. The results were analysed with the Mann-Whitney U test and Spearman correlation coefficient. A p value of ≤0.05 was considered statistically significant. Sequential results were compared using Blant-Alpman plot.
Results: The patients were grouped as HBeAg-positive (37.2%) and HBeAg-negative (62.8%). Serum ALT levels were elevated in 82% of HBeAg-positive and 70.2% of HBeAg-negative subjects. There was a statistically significant difference in HBsAg levels between the groups (p0.05). A statistically significant negative correlation was detected between HBsAg and HBV DNA levels in HBeAg-positive patients. No correlation was found between HBsAg and HBV DNA levels in HBeAg-negative subjects (p |
| doi_str_mv | 10.4274/vhd.73645 |
| format | Article |
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Material and Methods: A retrospective study was conducted in 59 chronic hepatitis B patients. Serum ALT, HBsAg and HBeAg levels and HBV DNA levels were recorded. The results were analysed with the Mann-Whitney U test and Spearman correlation coefficient. A p value of ≤0.05 was considered statistically significant. Sequential results were compared using Blant-Alpman plot.
Results: The patients were grouped as HBeAg-positive (37.2%) and HBeAg-negative (62.8%). Serum ALT levels were elevated in 82% of HBeAg-positive and 70.2% of HBeAg-negative subjects. There was a statistically significant difference in HBsAg levels between the groups (p<0.05). However, there was no statistically significant difference in ALT and HBV DNA levels (p>0.05). A statistically significant negative correlation was detected between HBsAg and HBV DNA levels in HBeAg-positive patients. No correlation was found between HBsAg and HBV DNA levels in HBeAg-negative subjects (p<0.05). In both HBeAg-positive and -negative individuals, there was a positive correlation between serum ALT and HBV DNA levels (p<0.05). Blant-Alpman graph did not show an appropriate profile.
Conclusion: We found a negative correlation between HBsAg and HBV DNA levels in HBeAg-positive patients. However, this correlation is not practical in monitoring treatment response and replication.</description><identifier>ISSN: 1307-9441</identifier><identifier>EISSN: 2147-2939</identifier><identifier>DOI: 10.4274/vhd.73645</identifier><language>eng</language><publisher>Ankara: Viral Hepatitle Savaşım Derneği</publisher><subject>Antigens ; Deoxyribonucleic acid ; DNA ; Hepatitis ; Hepatitis B ; Infections ; Interferon ; Liver diseases ; Proteins ; Statistical analysis ; Studies ; Tıp ; Viruses</subject><ispartof>Viral Hepatit Dergisi, 2017-08, Vol.23 (2), p.55-59</ispartof><rights>2017. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><contributor>Tabak,Fehmi Ömer</contributor><creatorcontrib>UZUNOĞLU, Emel</creatorcontrib><creatorcontrib>ŞAHİN, Ahmet Melih</creatorcontrib><creatorcontrib>AVCI, Esin</creatorcontrib><creatorcontrib>KUTLU, Hakan</creatorcontrib><creatorcontrib>GÜNTEPE, Gökçe</creatorcontrib><title>Can HBsAg Be Used as a Viral Replication Marker in Chronic Hepatitis B Patients?</title><title>Viral Hepatit Dergisi</title><description>Objective: Monitoring hepatitis B virus (HBV) treatment responses and virus replication is performed with molecular tests. However, these tests are either expensive or invasive. A new and more practical marker is needed. We aimed to evaluate the correlation between serum hepatitis B surface antigen (HBsAg) and alanine aminotransferase (ALT) levels and HBV DNA level in hepatitis B e antigen (HBeAg) +/- patients and detect whether HBsAg can be used as a surrogate replication marker instead of HBV DNA.
Material and Methods: A retrospective study was conducted in 59 chronic hepatitis B patients. Serum ALT, HBsAg and HBeAg levels and HBV DNA levels were recorded. The results were analysed with the Mann-Whitney U test and Spearman correlation coefficient. A p value of ≤0.05 was considered statistically significant. Sequential results were compared using Blant-Alpman plot.
Results: The patients were grouped as HBeAg-positive (37.2%) and HBeAg-negative (62.8%). Serum ALT levels were elevated in 82% of HBeAg-positive and 70.2% of HBeAg-negative subjects. There was a statistically significant difference in HBsAg levels between the groups (p<0.05). However, there was no statistically significant difference in ALT and HBV DNA levels (p>0.05). A statistically significant negative correlation was detected between HBsAg and HBV DNA levels in HBeAg-positive patients. No correlation was found between HBsAg and HBV DNA levels in HBeAg-negative subjects (p<0.05). In both HBeAg-positive and -negative individuals, there was a positive correlation between serum ALT and HBV DNA levels (p<0.05). Blant-Alpman graph did not show an appropriate profile.
Conclusion: We found a negative correlation between HBsAg and HBV DNA levels in HBeAg-positive patients. However, this correlation is not practical in monitoring treatment response and replication.</description><subject>Antigens</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Infections</subject><subject>Interferon</subject><subject>Liver diseases</subject><subject>Proteins</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Tıp</subject><subject>Viruses</subject><issn>1307-9441</issn><issn>2147-2939</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpF0E1LAzEQBuAgChbtwX8Q8CAetuZzszlJu1ZbqFjEeg3ZbNZG1-yabAX_vdEKnmZgHmaGF4AzjCaMCHb1ua0nguaMH4ARwUxkRFJ5CEaYIpFJxvAxGMfoKsSYSErwEViX2sPFLE5f4MzCTbQ11BFq-OyCbuGj7Vtn9OA6D-91eLMBOg_Lbei8M3Bh-zQaXIQzuE6d9UO8PgVHjW6jHf_VE7C5nT-Vi2z1cLcsp6vMpM-GDDeIU4krrqkldcOYbgxmUjQ4NxWWpuaFLizhOaNIFrIoEDdNlRPKsdaVRPQEnO_39qH72Nk4qNduF3w6qQjGgiCGcpHUxV652uq2863z9h8ub-bTlco5k3mSl3tpQhdjsI3qg3vX4UthpH7SVSld9Zsu_Qa4Hmmg</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>UZUNOĞLU, Emel</creator><creator>ŞAHİN, Ahmet Melih</creator><creator>AVCI, Esin</creator><creator>KUTLU, Hakan</creator><creator>GÜNTEPE, Gökçe</creator><general>Viral Hepatitle Savaşım Derneği</general><general>Galenos Publishing House</general><scope>AAYXX</scope><scope>CITATION</scope><scope>IEBAR</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20170801</creationdate><title>Can HBsAg Be Used as a Viral Replication Marker in Chronic Hepatitis B Patients?</title><author>UZUNOĞLU, Emel ; ŞAHİN, Ahmet Melih ; AVCI, Esin ; KUTLU, Hakan ; GÜNTEPE, Gökçe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c214t-1f05391b5a3e2df44afc1497f16cb19cd58a8e2564309898805cfb62351aab903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Antigens</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Hepatitis</topic><topic>Hepatitis B</topic><topic>Infections</topic><topic>Interferon</topic><topic>Liver diseases</topic><topic>Proteins</topic><topic>Statistical analysis</topic><topic>Studies</topic><topic>Tıp</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>UZUNOĞLU, Emel</creatorcontrib><creatorcontrib>ŞAHİN, Ahmet Melih</creatorcontrib><creatorcontrib>AVCI, Esin</creatorcontrib><creatorcontrib>KUTLU, Hakan</creatorcontrib><creatorcontrib>GÜNTEPE, Gökçe</creatorcontrib><collection>CrossRef</collection><collection>Idealonline online kütüphane - Journals</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Viral Hepatit Dergisi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>UZUNOĞLU, Emel</au><au>ŞAHİN, Ahmet Melih</au><au>AVCI, Esin</au><au>KUTLU, Hakan</au><au>GÜNTEPE, Gökçe</au><au>Tabak,Fehmi Ömer</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Can HBsAg Be Used as a Viral Replication Marker in Chronic Hepatitis B Patients?</atitle><jtitle>Viral Hepatit Dergisi</jtitle><date>2017-08-01</date><risdate>2017</risdate><volume>23</volume><issue>2</issue><spage>55</spage><epage>59</epage><pages>55-59</pages><issn>1307-9441</issn><eissn>2147-2939</eissn><abstract>Objective: Monitoring hepatitis B virus (HBV) treatment responses and virus replication is performed with molecular tests. However, these tests are either expensive or invasive. A new and more practical marker is needed. We aimed to evaluate the correlation between serum hepatitis B surface antigen (HBsAg) and alanine aminotransferase (ALT) levels and HBV DNA level in hepatitis B e antigen (HBeAg) +/- patients and detect whether HBsAg can be used as a surrogate replication marker instead of HBV DNA.
Material and Methods: A retrospective study was conducted in 59 chronic hepatitis B patients. Serum ALT, HBsAg and HBeAg levels and HBV DNA levels were recorded. The results were analysed with the Mann-Whitney U test and Spearman correlation coefficient. A p value of ≤0.05 was considered statistically significant. Sequential results were compared using Blant-Alpman plot.
Results: The patients were grouped as HBeAg-positive (37.2%) and HBeAg-negative (62.8%). Serum ALT levels were elevated in 82% of HBeAg-positive and 70.2% of HBeAg-negative subjects. There was a statistically significant difference in HBsAg levels between the groups (p<0.05). However, there was no statistically significant difference in ALT and HBV DNA levels (p>0.05). A statistically significant negative correlation was detected between HBsAg and HBV DNA levels in HBeAg-positive patients. No correlation was found between HBsAg and HBV DNA levels in HBeAg-negative subjects (p<0.05). In both HBeAg-positive and -negative individuals, there was a positive correlation between serum ALT and HBV DNA levels (p<0.05). Blant-Alpman graph did not show an appropriate profile.
Conclusion: We found a negative correlation between HBsAg and HBV DNA levels in HBeAg-positive patients. However, this correlation is not practical in monitoring treatment response and replication.</abstract><cop>Ankara</cop><pub>Viral Hepatitle Savaşım Derneği</pub><doi>10.4274/vhd.73645</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antigens Deoxyribonucleic acid DNA Hepatitis Hepatitis B Infections Interferon Liver diseases Proteins Statistical analysis Studies Tıp Viruses |
| title | Can HBsAg Be Used as a Viral Replication Marker in Chronic Hepatitis B Patients? |
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