Synthesis and Molecular Docking Studies of Novel 2-(2-Amino-6-Phenyl-4-Pyrimidinylamino) Ethanol Derivatives: Using Ring-Opening Reactions of Cyclic Ketene-N,O-Acetal
A series of six novel 2-(2-amino-6-phenyl-4-pyrimidinylamino) ethanol derivatives have been synthesized starting from commercially available substituted acetophenones via OxoketeneDithioacetals with high yields. Ketene dithioacetals to react with 2-aminoethanol or l-amino-2-propanol to afford the co...
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| Veröffentlicht in: | Oriental journal of chemistry 2017-01, Vol.33 (3), p.1555-1562 |
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| container_title | Oriental journal of chemistry |
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| creator | Kumar G. M. V. N. A. R., Ravi Thangamani, Arumugam |
| description | A series of six novel 2-(2-amino-6-phenyl-4-pyrimidinylamino) ethanol derivatives have been synthesized starting from commercially available substituted acetophenones via OxoketeneDithioacetals with high yields. Ketene dithioacetals to react with 2-aminoethanol or l-amino-2-propanol to afford the corresponding substituted 2-methyleneoxazolidines which are utilized in the synthesis of 6-aryl-2-amino-4-pyrimidinamine Derivatives. The molecular docking studies revealed that all the synthesized compounds best fit into the active site of HDAC2, anti-cancer protein. |
| doi_str_mv | 10.13005/ojc/330361 |
| format | Article |
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| subjects | Antimicrobial agents Aromatic compounds Cancer Chemical synthesis Derivatives Ethanol Ligands Molecular docking Pharmaceutical sciences Proteins Substitutes |
| title | Synthesis and Molecular Docking Studies of Novel 2-(2-Amino-6-Phenyl-4-Pyrimidinylamino) Ethanol Derivatives: Using Ring-Opening Reactions of Cyclic Ketene-N,O-Acetal |
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