Successful Fecal Microbiota Transplantation in a Patient with Severe Complicated Clostridium difficile Infection after Liver Transplantation
Clostridium difficile infection (CDI) represents one of the most common healthcare-associated infections. Due to increasing numbers of recurrences and therapy failures, CDI has become a major disease burden. Studies have shown that fecal microbiota transplantation (FMT) can both be a safe and highly...
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| Veröffentlicht in: | Case Reports in Gastroenterology 2018-01, Vol.12 (1), p.76-84 |
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| container_title | Case Reports in Gastroenterology |
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| creator | Schneider, Kai Markus Wirtz, Theresa H. Kroy, Daniela Albers, Stefanie Neumann, Ulf Peter Strowig, Till Sellge, Gernot Trautwein, Christian |
| description | Clostridium difficile infection (CDI) represents one of the most common healthcare-associated infections. Due to increasing numbers of recurrences and therapy failures, CDI has become a major disease burden. Studies have shown that fecal microbiota transplantation (FMT) can both be a safe and highly efficacious therapy for patients with therapy-refractory CDI. However, patients undergoing solid organ transplantation are at high risk for CDI due to long-term immunosuppression, previous antibiotic therapy, and proton pump inhibitor use. Additionally, these patients may be especially prone to adverse events related to FMT. Here, we report a successful FMT in a patient with severe therapy-refractory CDI after liver transplantation. |
| doi_str_mv | 10.1159/000481937 |
| format | Article |
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Due to increasing numbers of recurrences and therapy failures, CDI has become a major disease burden. Studies have shown that fecal microbiota transplantation (FMT) can both be a safe and highly efficacious therapy for patients with therapy-refractory CDI. However, patients undergoing solid organ transplantation are at high risk for CDI due to long-term immunosuppression, previous antibiotic therapy, and proton pump inhibitor use. Additionally, these patients may be especially prone to adverse events related to FMT. Here, we report a successful FMT in a patient with severe therapy-refractory CDI after liver transplantation.</description><identifier>ISSN: 1662-0631</identifier><identifier>EISSN: 1662-0631</identifier><identifier>DOI: 10.1159/000481937</identifier><identifier>PMID: 29606940</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Abdomen ; Antibiotics ; Bacterial infections ; Care and treatment ; Case and Review ; Case reports ; Clostridium difficile infection ; Colitis ; Diarrhea ; Fecal microbiota transplantation ; Feces ; Fidaxomicin ; Health aspects ; Immunotherapy ; Infection ; Infections ; Infectious diseases ; Inflammatory bowel disease ; Liver ; Liver transplantation ; Liver transplants ; Medical research ; Metronidazole ; Microbiota ; Microbiota (Symbiotic organisms) ; Organ transplantation ; Patients ; Pseudomembranous colitis ; Surgery ; Transplants & implants ; Ultrasonic imaging</subject><ispartof>Case Reports in Gastroenterology, 2018-01, Vol.12 (1), p.76-84</ispartof><rights>2018 The Author(s). Published by S. Karger AG, Basel</rights><rights>COPYRIGHT 2018 S. Karger AG</rights><rights>Copyright © 2018 by S. Karger AG, Basel 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5007-ae5d808165ec9529af9214ecf4241fab92a820110709cfa434e492a7d4c1f5823</citedby><cites>FETCH-LOGICAL-c5007-ae5d808165ec9529af9214ecf4241fab92a820110709cfa434e492a7d4c1f5823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869577/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869577/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,27612,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29606940$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schneider, Kai Markus</creatorcontrib><creatorcontrib>Wirtz, Theresa H.</creatorcontrib><creatorcontrib>Kroy, Daniela</creatorcontrib><creatorcontrib>Albers, Stefanie</creatorcontrib><creatorcontrib>Neumann, Ulf Peter</creatorcontrib><creatorcontrib>Strowig, Till</creatorcontrib><creatorcontrib>Sellge, Gernot</creatorcontrib><creatorcontrib>Trautwein, Christian</creatorcontrib><title>Successful Fecal Microbiota Transplantation in a Patient with Severe Complicated Clostridium difficile Infection after Liver Transplantation</title><title>Case Reports in Gastroenterology</title><addtitle>Case Rep Gastroenterol</addtitle><description>Clostridium difficile infection (CDI) represents one of the most common healthcare-associated infections. Due to increasing numbers of recurrences and therapy failures, CDI has become a major disease burden. Studies have shown that fecal microbiota transplantation (FMT) can both be a safe and highly efficacious therapy for patients with therapy-refractory CDI. However, patients undergoing solid organ transplantation are at high risk for CDI due to long-term immunosuppression, previous antibiotic therapy, and proton pump inhibitor use. Additionally, these patients may be especially prone to adverse events related to FMT. Here, we report a successful FMT in a patient with severe therapy-refractory CDI after liver transplantation.</description><subject>Abdomen</subject><subject>Antibiotics</subject><subject>Bacterial infections</subject><subject>Care and treatment</subject><subject>Case and Review</subject><subject>Case reports</subject><subject>Clostridium difficile infection</subject><subject>Colitis</subject><subject>Diarrhea</subject><subject>Fecal microbiota transplantation</subject><subject>Feces</subject><subject>Fidaxomicin</subject><subject>Health aspects</subject><subject>Immunotherapy</subject><subject>Infection</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Inflammatory bowel disease</subject><subject>Liver</subject><subject>Liver transplantation</subject><subject>Liver transplants</subject><subject>Medical research</subject><subject>Metronidazole</subject><subject>Microbiota</subject><subject>Microbiota (Symbiotic organisms)</subject><subject>Organ transplantation</subject><subject>Patients</subject><subject>Pseudomembranous colitis</subject><subject>Surgery</subject><subject>Transplants & implants</subject><subject>Ultrasonic imaging</subject><issn>1662-0631</issn><issn>1662-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptkk1v1DAQhiMEoqVw4I6QpV7gsGXsOIl9QaoiWlZaBKLlbDnOeOslibd2UsR_4EfjbcqqrZAPtmbeecbzkWWvKZxQWsgPAMAFlXn1JDukZckWUOb06b33QfYixg1AyVlOn2cHTJZQSg6H2Z-LyRiM0U4dOUOjO_LFmeAb50dNLoMe4rbTw6hH5wfiBqLJt_TGYSS_3HhFLvAGA5La99vOGT1iS-rOxzG41k09aZ21zrgOyXKwaG4h2o4YyMqlwMcJXmbPrO4ivrq7j7IfZ58u68-L1dfzZX26WpgCoFpoLFoBgpYFGlkwqa1klKOxnHFqdSOZFgwohQqksZrnHHmyVS031BaC5UfZcua2Xm_UNrheh9_Ka6duDT6slQ6jMx2qlKSyjKX2NgUXLReGNxwaWfIcudAisT7OrO3U9Nia1JqguwfQh57BXam1v1GFKGVRVQnw7g4Q_PWEcVS9iwa71BX0U1QMGAgpCrbLdfxIuvFTGFKrFKO0YgACdsCTWbXWqQA3WJ_ymnRa7J3xA9o0EHVaiESVIpcp4P0ckAYfY0C7_z0FtVswtV-wpH17v9y98t9GJcGbWfBThzWGvWAff_xfd_39fFaobWvzvyCc4NI</recordid><startdate>201801</startdate><enddate>201801</enddate><creator>Schneider, Kai Markus</creator><creator>Wirtz, Theresa H.</creator><creator>Kroy, Daniela</creator><creator>Albers, Stefanie</creator><creator>Neumann, Ulf Peter</creator><creator>Strowig, Till</creator><creator>Sellge, Gernot</creator><creator>Trautwein, Christian</creator><general>S. Karger AG</general><general>Karger Publishers</general><scope>M--</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>201801</creationdate><title>Successful Fecal Microbiota Transplantation in a Patient with Severe Complicated Clostridium difficile Infection after Liver Transplantation</title><author>Schneider, Kai Markus ; Wirtz, Theresa H. ; Kroy, Daniela ; Albers, Stefanie ; Neumann, Ulf Peter ; Strowig, Till ; Sellge, Gernot ; Trautwein, Christian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5007-ae5d808165ec9529af9214ecf4241fab92a820110709cfa434e492a7d4c1f5823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Abdomen</topic><topic>Antibiotics</topic><topic>Bacterial infections</topic><topic>Care and treatment</topic><topic>Case and Review</topic><topic>Case reports</topic><topic>Clostridium difficile infection</topic><topic>Colitis</topic><topic>Diarrhea</topic><topic>Fecal microbiota transplantation</topic><topic>Feces</topic><topic>Fidaxomicin</topic><topic>Health aspects</topic><topic>Immunotherapy</topic><topic>Infection</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Inflammatory bowel disease</topic><topic>Liver</topic><topic>Liver transplantation</topic><topic>Liver transplants</topic><topic>Medical research</topic><topic>Metronidazole</topic><topic>Microbiota</topic><topic>Microbiota (Symbiotic organisms)</topic><topic>Organ transplantation</topic><topic>Patients</topic><topic>Pseudomembranous colitis</topic><topic>Surgery</topic><topic>Transplants & implants</topic><topic>Ultrasonic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schneider, Kai Markus</creatorcontrib><creatorcontrib>Wirtz, Theresa H.</creatorcontrib><creatorcontrib>Kroy, Daniela</creatorcontrib><creatorcontrib>Albers, Stefanie</creatorcontrib><creatorcontrib>Neumann, Ulf Peter</creatorcontrib><creatorcontrib>Strowig, Till</creatorcontrib><creatorcontrib>Sellge, Gernot</creatorcontrib><creatorcontrib>Trautwein, Christian</creatorcontrib><collection>Karger Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Case Reports in Gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schneider, Kai Markus</au><au>Wirtz, Theresa H.</au><au>Kroy, Daniela</au><au>Albers, Stefanie</au><au>Neumann, Ulf Peter</au><au>Strowig, Till</au><au>Sellge, Gernot</au><au>Trautwein, Christian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Successful Fecal Microbiota Transplantation in a Patient with Severe Complicated Clostridium difficile Infection after Liver Transplantation</atitle><jtitle>Case Reports in Gastroenterology</jtitle><addtitle>Case Rep Gastroenterol</addtitle><date>2018-01</date><risdate>2018</risdate><volume>12</volume><issue>1</issue><spage>76</spage><epage>84</epage><pages>76-84</pages><issn>1662-0631</issn><eissn>1662-0631</eissn><abstract>Clostridium difficile infection (CDI) represents one of the most common healthcare-associated infections. Due to increasing numbers of recurrences and therapy failures, CDI has become a major disease burden. Studies have shown that fecal microbiota transplantation (FMT) can both be a safe and highly efficacious therapy for patients with therapy-refractory CDI. However, patients undergoing solid organ transplantation are at high risk for CDI due to long-term immunosuppression, previous antibiotic therapy, and proton pump inhibitor use. Additionally, these patients may be especially prone to adverse events related to FMT. Here, we report a successful FMT in a patient with severe therapy-refractory CDI after liver transplantation.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>29606940</pmid><doi>10.1159/000481937</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Abdomen Antibiotics Bacterial infections Care and treatment Case and Review Case reports Clostridium difficile infection Colitis Diarrhea Fecal microbiota transplantation Feces Fidaxomicin Health aspects Immunotherapy Infection Infections Infectious diseases Inflammatory bowel disease Liver Liver transplantation Liver transplants Medical research Metronidazole Microbiota Microbiota (Symbiotic organisms) Organ transplantation Patients Pseudomembranous colitis Surgery Transplants & implants Ultrasonic imaging |
| title | Successful Fecal Microbiota Transplantation in a Patient with Severe Complicated Clostridium difficile Infection after Liver Transplantation |
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