Synthesis and Study of Modified Polyvinyl Alcohol Containing Amino acid moieties as Anticancer Agent
A series of new phthalimides compounds were synthesized from reaction of Malic anhydride, phthalic anhydride, nitro phthalic anhydride, 2-phenyl-4H-benzo[d][1,3]oxazin-4-one, 2-(4-nitrophenyl)-4H-benzo[d][1,3]oxazin-4-one with different amino acids as glycine, alanine, valine, leucine, isoleucine, s...
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| Veröffentlicht in: | Oriental journal of chemistry 2018-01, Vol.34 (1), p.286-294 |
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| container_title | Oriental journal of chemistry |
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| creator | Samir, Ali H Saeed, Ruwaidah S Matty, Fadhel S |
| description | A series of new phthalimides compounds were synthesized from reaction of Malic anhydride, phthalic anhydride, nitro phthalic anhydride, 2-phenyl-4H-benzo[d][1,3]oxazin-4-one, 2-(4-nitrophenyl)-4H-benzo[d][1,3]oxazin-4-one with different amino acids as glycine, alanine, valine, leucine, isoleucine, serine, threonine, tyrosine and Phenyl alanine [1]a-i under fusion conditions. Compounds react with SOCl2 in the presence of benzene to produce compounds. Chemical modification of Poly (vinyl alcohol) were obtained by reaction of PVA with compounds using the dimethyl formamide to give compounds. The structure of the synthesized compounds was characterized by their analytical and spectral data as, IR spectra,1H, C13-NMR, Elemental analysis (CHN), UV-Vis Spectroscopy, Scanning electron microscopy (SEM), Antibacterial activity were screened via two kinds of bacteria. Also, anticancer activity were examined for most of the modified polyvinyl alcohol. |
| doi_str_mv | 10.13005/ojc/340131 |
| format | Article |
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Compounds react with SOCl2 in the presence of benzene to produce compounds. Chemical modification of Poly (vinyl alcohol) were obtained by reaction of PVA with compounds using the dimethyl formamide to give compounds. The structure of the synthesized compounds was characterized by their analytical and spectral data as, IR spectra,1H, C13-NMR, Elemental analysis (CHN), UV-Vis Spectroscopy, Scanning electron microscopy (SEM), Antibacterial activity were screened via two kinds of bacteria. Also, anticancer activity were examined for most of the modified polyvinyl alcohol.</description><identifier>ISSN: 0970-020X</identifier><identifier>EISSN: 2231-5039</identifier><identifier>DOI: 10.13005/ojc/340131</identifier><language>eng</language><publisher>Bhopal: Oriental Scientific Publishing Company</publisher><subject>Alanine ; Amino acids ; Anhydrides ; Anticancer properties ; Antimicrobial agents ; Benzene ; Cancer ; Chemical compounds ; Chemical synthesis ; Chloride ; Cytotoxicity ; Dimethylformamide ; Ethanol ; Glycine ; Hydrocarbons ; Infrared spectroscopy ; Leucine ; NMR ; Nuclear magnetic resonance ; Organic chemistry ; Phthalic anhydride ; Phthalimides ; Physical properties ; Polyesters ; Polymers ; Polyvinyl alcohol ; Scanning electron microscopy ; Tyrosine ; Valine</subject><ispartof>Oriental journal of chemistry, 2018-01, Vol.34 (1), p.286-294</ispartof><rights>2018. This work is published under http://creativecommons.org/licenses/by-nc-sa/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c298t-43226dcd5aa3b899cc0413acb7a27af0f8778c26af96bb673c72c26dd2fefc9f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Samir, Ali H</creatorcontrib><creatorcontrib>Saeed, Ruwaidah S</creatorcontrib><creatorcontrib>Matty, Fadhel S</creatorcontrib><title>Synthesis and Study of Modified Polyvinyl Alcohol Containing Amino acid moieties as Anticancer Agent</title><title>Oriental journal of chemistry</title><description>A series of new phthalimides compounds were synthesized from reaction of Malic anhydride, phthalic anhydride, nitro phthalic anhydride, 2-phenyl-4H-benzo[d][1,3]oxazin-4-one, 2-(4-nitrophenyl)-4H-benzo[d][1,3]oxazin-4-one with different amino acids as glycine, alanine, valine, leucine, isoleucine, serine, threonine, tyrosine and Phenyl alanine [1]a-i under fusion conditions. Compounds react with SOCl2 in the presence of benzene to produce compounds. Chemical modification of Poly (vinyl alcohol) were obtained by reaction of PVA with compounds using the dimethyl formamide to give compounds. The structure of the synthesized compounds was characterized by their analytical and spectral data as, IR spectra,1H, C13-NMR, Elemental analysis (CHN), UV-Vis Spectroscopy, Scanning electron microscopy (SEM), Antibacterial activity were screened via two kinds of bacteria. Also, anticancer activity were examined for most of the modified polyvinyl alcohol.</description><subject>Alanine</subject><subject>Amino acids</subject><subject>Anhydrides</subject><subject>Anticancer properties</subject><subject>Antimicrobial agents</subject><subject>Benzene</subject><subject>Cancer</subject><subject>Chemical compounds</subject><subject>Chemical synthesis</subject><subject>Chloride</subject><subject>Cytotoxicity</subject><subject>Dimethylformamide</subject><subject>Ethanol</subject><subject>Glycine</subject><subject>Hydrocarbons</subject><subject>Infrared spectroscopy</subject><subject>Leucine</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Organic chemistry</subject><subject>Phthalic anhydride</subject><subject>Phthalimides</subject><subject>Physical properties</subject><subject>Polyesters</subject><subject>Polymers</subject><subject>Polyvinyl alcohol</subject><subject>Scanning electron microscopy</subject><subject>Tyrosine</subject><subject>Valine</subject><issn>0970-020X</issn><issn>2231-5039</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNotkE1LAzEYhIMoWGpP_oGAR1nNx-5mc1yKX1BRqIK3JfsmaVO2SU1SYf-9i3Uuw8AwAw9C15TcUU5IdR92cM9LQjk9QzPGOC0qwuU5mhEpSEEY-bpEi5R2ZJIseU2rGdLr0eetSS5h5TVe56MecbD4NWhnndH4PQzjj_PjgNsBwjYMeBl8Vs47v8Ht3vmAFTiN98GZ7Mw0k3DrswPlwUTcbozPV-jCqiGZxb_P0efjw8fyuVi9Pb0s21UBTDa5KDljtQZdKcX7RkoAUlKuoBeKCWWJbYRogNXKyrrva8FBsClqzayxIC2fo5vT7iGG76NJuduFY_TTZccoFVQ2pain1u2pBTGkFI3tDtHtVRw7Sro_kt1EsjuR5L_EkGdM</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Samir, Ali H</creator><creator>Saeed, Ruwaidah S</creator><creator>Matty, Fadhel S</creator><general>Oriental Scientific Publishing Company</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20180101</creationdate><title>Synthesis and Study of Modified Polyvinyl Alcohol Containing Amino acid moieties as Anticancer Agent</title><author>Samir, Ali H ; Saeed, Ruwaidah S ; Matty, Fadhel S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c298t-43226dcd5aa3b899cc0413acb7a27af0f8778c26af96bb673c72c26dd2fefc9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Alanine</topic><topic>Amino acids</topic><topic>Anhydrides</topic><topic>Anticancer properties</topic><topic>Antimicrobial agents</topic><topic>Benzene</topic><topic>Cancer</topic><topic>Chemical compounds</topic><topic>Chemical synthesis</topic><topic>Chloride</topic><topic>Cytotoxicity</topic><topic>Dimethylformamide</topic><topic>Ethanol</topic><topic>Glycine</topic><topic>Hydrocarbons</topic><topic>Infrared spectroscopy</topic><topic>Leucine</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Organic chemistry</topic><topic>Phthalic anhydride</topic><topic>Phthalimides</topic><topic>Physical properties</topic><topic>Polyesters</topic><topic>Polymers</topic><topic>Polyvinyl alcohol</topic><topic>Scanning electron microscopy</topic><topic>Tyrosine</topic><topic>Valine</topic><toplevel>online_resources</toplevel><creatorcontrib>Samir, Ali H</creatorcontrib><creatorcontrib>Saeed, Ruwaidah S</creatorcontrib><creatorcontrib>Matty, Fadhel S</creatorcontrib><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Oriental journal of chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Samir, Ali H</au><au>Saeed, Ruwaidah S</au><au>Matty, Fadhel S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and Study of Modified Polyvinyl Alcohol Containing Amino acid moieties as Anticancer Agent</atitle><jtitle>Oriental journal of chemistry</jtitle><date>2018-01-01</date><risdate>2018</risdate><volume>34</volume><issue>1</issue><spage>286</spage><epage>294</epage><pages>286-294</pages><issn>0970-020X</issn><eissn>2231-5039</eissn><abstract>A series of new phthalimides compounds were synthesized from reaction of Malic anhydride, phthalic anhydride, nitro phthalic anhydride, 2-phenyl-4H-benzo[d][1,3]oxazin-4-one, 2-(4-nitrophenyl)-4H-benzo[d][1,3]oxazin-4-one with different amino acids as glycine, alanine, valine, leucine, isoleucine, serine, threonine, tyrosine and Phenyl alanine [1]a-i under fusion conditions. 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| subjects | Alanine Amino acids Anhydrides Anticancer properties Antimicrobial agents Benzene Cancer Chemical compounds Chemical synthesis Chloride Cytotoxicity Dimethylformamide Ethanol Glycine Hydrocarbons Infrared spectroscopy Leucine NMR Nuclear magnetic resonance Organic chemistry Phthalic anhydride Phthalimides Physical properties Polyesters Polymers Polyvinyl alcohol Scanning electron microscopy Tyrosine Valine |
| title | Synthesis and Study of Modified Polyvinyl Alcohol Containing Amino acid moieties as Anticancer Agent |
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