Antioxidant Activity of Alkaloid Compounds from Litsea cubeba Lour
Litsea cubeba (Lour.) heartwood. was extracted by maceration. Ethanol extract was fractionated with liquid-liquid extraction using n-hexane, chloroform at pH 3, 7, 9 and 11 to obtained alkaloid fractions. Isolation of alkaloid compounds were isolated with preparative thin layer chromatography. Antio...
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| Veröffentlicht in: | Oriental journal of chemistry 2018-01, Vol.34 (2), p.1149-1152 |
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| creator | Dalimunthe, Aminah Anjelisa Zaitun Hasibuan, Poppy Silalahi, Jansen Fatimah Sinaga, Siti Satria, Denny |
| description | Litsea cubeba (Lour.) heartwood. was extracted by maceration. Ethanol extract was fractionated with liquid-liquid extraction using n-hexane, chloroform at pH 3, 7, 9 and 11 to obtained alkaloid fractions. Isolation of alkaloid compounds were isolated with preparative thin layer chromatography. Antioxidant activity for fractions and isolates were determined with DPPH and ABTS assay. The highest IC50 were given by chloroform fractions at pH 7 and compound III. They IC50 were 23.81 ± 0.01; 3.12 ± 0.02 µg/mL for DPPH assay and 56.43 ± 0.06; 8.62 ± 0.02 µg/mL for ABTS assay. Compound III was showed maximum absorbance at (302.8; 280.8; 206 nm) and wave number (3286.70; 3109.25; 2939.52; 2835.36; 1589.34; 1462.04; 1365.60; 1246.02; 1018.41; 879.54 cm-1) which indicate its an alkaloid compound with hydroxyl, methyl, methylene and methoxy group. The results reveal that alkaloid fractions and compounds of Litsea cubeba heartwood has very strong antioxidant potential. |
| doi_str_mv | 10.13005/ojc/340270 |
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Ethanol extract was fractionated with liquid-liquid extraction using n-hexane, chloroform at pH 3, 7, 9 and 11 to obtained alkaloid fractions. Isolation of alkaloid compounds were isolated with preparative thin layer chromatography. Antioxidant activity for fractions and isolates were determined with DPPH and ABTS assay. The highest IC50 were given by chloroform fractions at pH 7 and compound III. They IC50 were 23.81 ± 0.01; 3.12 ± 0.02 µg/mL for DPPH assay and 56.43 ± 0.06; 8.62 ± 0.02 µg/mL for ABTS assay. Compound III was showed maximum absorbance at (302.8; 280.8; 206 nm) and wave number (3286.70; 3109.25; 2939.52; 2835.36; 1589.34; 1462.04; 1365.60; 1246.02; 1018.41; 879.54 cm-1) which indicate its an alkaloid compound with hydroxyl, methyl, methylene and methoxy group. The results reveal that alkaloid fractions and compounds of Litsea cubeba heartwood has very strong antioxidant potential.</description><identifier>ISSN: 0970-020X</identifier><identifier>EISSN: 2231-5039</identifier><identifier>DOI: 10.13005/ojc/340270</identifier><language>eng</language><publisher>Bhopal: Oriental Scientific Publishing Company</publisher><subject>Antioxidants ; Assaying ; Breast cancer ; Chloroform ; Ethanol ; Flavonoids ; Free radicals ; Liquid-liquid extraction ; Maceration ; Oxidative stress ; Thin layer chromatography</subject><ispartof>Oriental journal of chemistry, 2018-01, Vol.34 (2), p.1149-1152</ispartof><rights>2018. This work is published under http://creativecommons.org/licenses/by-nc-sa/4.0/ (the “License”). 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Ethanol extract was fractionated with liquid-liquid extraction using n-hexane, chloroform at pH 3, 7, 9 and 11 to obtained alkaloid fractions. Isolation of alkaloid compounds were isolated with preparative thin layer chromatography. Antioxidant activity for fractions and isolates were determined with DPPH and ABTS assay. The highest IC50 were given by chloroform fractions at pH 7 and compound III. They IC50 were 23.81 ± 0.01; 3.12 ± 0.02 µg/mL for DPPH assay and 56.43 ± 0.06; 8.62 ± 0.02 µg/mL for ABTS assay. Compound III was showed maximum absorbance at (302.8; 280.8; 206 nm) and wave number (3286.70; 3109.25; 2939.52; 2835.36; 1589.34; 1462.04; 1365.60; 1246.02; 1018.41; 879.54 cm-1) which indicate its an alkaloid compound with hydroxyl, methyl, methylene and methoxy group. The results reveal that alkaloid fractions and compounds of Litsea cubeba heartwood has very strong antioxidant potential.</description><subject>Antioxidants</subject><subject>Assaying</subject><subject>Breast cancer</subject><subject>Chloroform</subject><subject>Ethanol</subject><subject>Flavonoids</subject><subject>Free radicals</subject><subject>Liquid-liquid extraction</subject><subject>Maceration</subject><subject>Oxidative stress</subject><subject>Thin layer chromatography</subject><issn>0970-020X</issn><issn>2231-5039</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNotkEtLAzEYRYMoWGpX_oGASxn75Z0sx-ILBtwouAuZTAJT20lNZsT-ewfr3dzN5R44CF0TuCMMQKzT1q8ZB6rgDC0oZaQSwMw5WoBRUAGFj0u0KmULcwxnkogFuq-HsU8_feeGEdd-7L_78YhTxPXu0-1S3-FN2h_SNHQFx5z2uOnHEhz2Uxtah5s05St0Ed2uhNV_L9H748Pb5rlqXp9eNnVTeSb5WPEgo2agvWqdCKZVMZoggjZScG2i6hyLmoaoDQA30osgqaROqK5T1HDHlujm9HvI6WsKZbTbmT7MSEsJUcRoDmxe3Z5WPqdScoj2kPu9y0dLwP55srMne_LEfgGbEFnl</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Dalimunthe, Aminah</creator><creator>Anjelisa Zaitun Hasibuan, Poppy</creator><creator>Silalahi, Jansen</creator><creator>Fatimah Sinaga, Siti</creator><creator>Satria, Denny</creator><general>Oriental Scientific Publishing Company</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20180101</creationdate><title>Antioxidant Activity of Alkaloid Compounds from Litsea cubeba Lour</title><author>Dalimunthe, Aminah ; Anjelisa Zaitun Hasibuan, Poppy ; Silalahi, Jansen ; Fatimah Sinaga, Siti ; Satria, Denny</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c364t-4e6f8308c7ba5e9b7ff9e5e8965489f7da3f82ef8900496c5e6262a57dd7294a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Antioxidants</topic><topic>Assaying</topic><topic>Breast cancer</topic><topic>Chloroform</topic><topic>Ethanol</topic><topic>Flavonoids</topic><topic>Free radicals</topic><topic>Liquid-liquid extraction</topic><topic>Maceration</topic><topic>Oxidative stress</topic><topic>Thin layer chromatography</topic><toplevel>online_resources</toplevel><creatorcontrib>Dalimunthe, Aminah</creatorcontrib><creatorcontrib>Anjelisa Zaitun Hasibuan, Poppy</creatorcontrib><creatorcontrib>Silalahi, Jansen</creatorcontrib><creatorcontrib>Fatimah Sinaga, Siti</creatorcontrib><creatorcontrib>Satria, Denny</creatorcontrib><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Oriental journal of chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dalimunthe, Aminah</au><au>Anjelisa Zaitun Hasibuan, Poppy</au><au>Silalahi, Jansen</au><au>Fatimah Sinaga, Siti</au><au>Satria, Denny</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antioxidant Activity of Alkaloid Compounds from Litsea cubeba Lour</atitle><jtitle>Oriental journal of chemistry</jtitle><date>2018-01-01</date><risdate>2018</risdate><volume>34</volume><issue>2</issue><spage>1149</spage><epage>1152</epage><pages>1149-1152</pages><issn>0970-020X</issn><eissn>2231-5039</eissn><abstract>Litsea cubeba (Lour.) heartwood. was extracted by maceration. Ethanol extract was fractionated with liquid-liquid extraction using n-hexane, chloroform at pH 3, 7, 9 and 11 to obtained alkaloid fractions. Isolation of alkaloid compounds were isolated with preparative thin layer chromatography. Antioxidant activity for fractions and isolates were determined with DPPH and ABTS assay. The highest IC50 were given by chloroform fractions at pH 7 and compound III. They IC50 were 23.81 ± 0.01; 3.12 ± 0.02 µg/mL for DPPH assay and 56.43 ± 0.06; 8.62 ± 0.02 µg/mL for ABTS assay. Compound III was showed maximum absorbance at (302.8; 280.8; 206 nm) and wave number (3286.70; 3109.25; 2939.52; 2835.36; 1589.34; 1462.04; 1365.60; 1246.02; 1018.41; 879.54 cm-1) which indicate its an alkaloid compound with hydroxyl, methyl, methylene and methoxy group. The results reveal that alkaloid fractions and compounds of Litsea cubeba heartwood has very strong antioxidant potential.</abstract><cop>Bhopal</cop><pub>Oriental Scientific Publishing Company</pub><doi>10.13005/ojc/340270</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antioxidants Assaying Breast cancer Chloroform Ethanol Flavonoids Free radicals Liquid-liquid extraction Maceration Oxidative stress Thin layer chromatography |
| title | Antioxidant Activity of Alkaloid Compounds from Litsea cubeba Lour |
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