A Tick Cysteine Protease Inhibitor RHcyst-1 Exhibits Antitumor Potential

Background/Aims: We previously identified a potent and tight-binding inhibitor of cysteine proteases from Rhipicephalus haemaphysaloides, RHcyst-1, which belongs to the cystatin type 1 family. Cathepsins, which are members of the cysteine protease family, participate in various pathological processe...

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Veröffentlicht in:	Cellular physiology and biochemistry 2018-01, Vol.46 (6), p.2385-2400
Hauptverfasser:	Wei, Nana, Lin, Zhibing, Xu, Zhengmao, Cao, Jie, Zhou, Yongzhi, Zhang, Houshuang, Gong, Haiyan, Zhou, Jinlin, Li, Guoqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Antineoplastic Agents - pharmacology Antitumor Apoptosis Arachnids Arthropods Cancer therapies Cathepsins Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Chemotherapy Cystatins - pharmacology Cysteine Proteinase Inhibitors - pharmacology Female Humans Invasion Laboratory animals Medical prognosis Melanoma Metastasis Mice, Inbred C57BL Migration Neoplasms - drug therapy Neoplasms - pathology Original Paper Plasmids Proliferation Proteins RHcyst-1 Ticks - enzymology Tumors
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