FG-4592 Accelerates Cutaneous Wound Healing by Epidermal Stem Cell Activation via HIF-1α Stabilization

Background/Aims: Regional hypoxia promptly develops after trauma because of microvascular injury and increased oxygen consumption. This acute hypoxia plays a positive role in early skin wound healing. One of the mechanisms underlying the beneficial effects of acute hypoxia on wound healing may be in...

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Veröffentlicht in:	Cellular physiology and biochemistry 2018-01, Vol.46 (6), p.2460-2470
Hauptverfasser:	Tang, Di, Zhang, Junhui, Yan, Tiantian, Wei, Jingyu, Jiang, Xupin, Zhang, Dongxia, Zhang, Qiong, Jia, Jiezhi, Huang, Yuesheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia Animals Cell growth Cell Hypoxia - drug effects Cell Proliferation - drug effects Cells, Cultured Epidermal Cells Epidermal Stem Cells Epidermis - drug effects Epidermis - metabolism Epidermis - pathology FG-4592 Glycine - analogs & derivatives Glycine - pharmacology Glycine - therapeutic use Growth factors HIF-1α Hyperplasia Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Isoquinolines - pharmacology Isoquinolines - therapeutic use Kidney diseases Laboratory animals Male Medical prognosis Mice Mice, Inbred BALB C Motility Original Paper Proliferation Protein Stability - drug effects Stem cells Stem Cells - cytology Stem Cells - drug effects Stem Cells - metabolism Wound Healing Wound Healing - drug effects
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