Induction of Pluripotent Stem Cell-Derived Cardiomyocyte Toxicity by Supernatant of Long Term-Stored Red Blood Cells in Vitro

Background/Aims: Preserved red blood cells (RBCs) in vitro undergo a series of morphological, functional and metabolic changes during storage. RBC metabolites accumulate over time during storage, the toxicity of the supernatants of RBCs (SSRBCs) on tissue cells is largely unknown. Here, we aimed to...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cellular Physiology and Biochemistry 2018-04, Vol.46 (3), p.1230-1240
Hauptverfasser:	Fan, Fengyan, Yu, Yang, Sun, Liping, Wang, Shufang, Wang, Rui, Zhang, Leiying, Li, Cuiying, Wang, Deqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis Biosensors Blood & organ donations Blood transfusions Cardiomyocytes Cardiotoxicity Cell culture Cell Differentiation Cells, Cultured Culture Media, Conditioned - pharmacology Cytotoxicity Erythrocytes Erythrocytes - cytology Erythrocytes - metabolism Gene expression Gene Expression Regulation - drug effects Heart surgery Human-induced pluripotent stem cell-derived cardiomyocytes Humans Induced Pluripotent Stem Cells - cytology Lactic Acid - analysis Male Metabolism Metabolites Microscopy, Fluorescence Mortality Myocytes, Cardiac - cytology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Original Paper Physiological aspects Potassium - analysis Properties Real-time cell analyzing Stem cells Suspended red blood cells Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!