Hydrogen Gas Attenuates Myocardial Ischemia Reperfusion Injury Independent of Postconditioning in Rats by Attenuating Endoplasmic Reticulum Stress-Induced Autophagy
Background/Aims: To study the effect of inhaling hydrogen gas on myocardial ischemic/reperfusion(I/R) injury in rats. Methods: Seventy male Wistar albino rats were divided into five groups at random as the sham group (Sham). The I/R group (I/R), The ischemic postconditioning group (IPo), The I/R plu...
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| creator | Gao, Yunan Yang, Hongxiao Chi, Jing Xu, Qiannan Zhao, Luqi Yang, Weijia Liu, Weifan Yang, Wei |
| description | Background/Aims: To study the effect of inhaling hydrogen gas on myocardial ischemic/reperfusion(I/R) injury in rats. Methods: Seventy male Wistar albino rats were divided into five groups at random as the sham group (Sham). The I/R group (I/R), The ischemic postconditioning group (IPo), The I/R plus hydrogen group (IH 2 ) and the ischemic postconditioning plus hydrogen group (IPoH 2 ). The Sham group was without coronary occlusion. In I/R group, Ischemic/reperfusion injury was induced by coronary occlusion for 1 hour. Followed by 2 hours of reperfusion. In the IPo and IPoH2 group, four cycles of 1 min reperfusion/1 min ischemia was given at the end of 1 hour coronary occlusion. While 2% hydrogen was administered by inhalation 5 min before reperfusion till 2 hours after reperfusion in both the IPoH2 and IH2 group. The heart and blood samples were harvested at the end of the surgical protocol. Then the myocardium cell endoplasmic reticulum(ER) stress and autophagy was observed by electron microscope. In addition, the cardiac ER stress and autophagy related proteins expression were detected by Western blotting analysis. Results: Both inhaling 2% hydrogen and ischemic postconditioning treatment reduced the ischemic size and serum troponin I level in rats with I/R injury, and inhaling hydrogen showed a more curative effect compared with ischemic postconditioning treatment. Meanwhile inhaling hydrogen showed a better protective effect in attenuating tissue reactive oxygen species. Malondialdehyde levels and immunoreactivities against 8-hydroxy-2’-deoxyguanosine and inhibiting cardiac endoplasmic reticulum stress and down-regulating autophagy as compared with ischemic postconditioning treatment. Conclusion: These results revealed a better protective effect of hydrogen on myocardial ischemic/reperfusion injury in rats by attenuating endoplasmic reticulum stress and down-regulating autophagy compared with ischemic postconditioning treatment. |
| doi_str_mv | 10.1159/000481974 |
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| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_proquest_journals_2117146475</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_fff1201be76045e6b05433c2c9932194</doaj_id><sourcerecordid>2117146475</sourcerecordid><originalsourceid>FETCH-LOGICAL-c529t-493d43cc6aaf0cb8b4706ac52d67bbf90392bb056a60d7beae887698e49e618e3</originalsourceid><addsrcrecordid>eNptkk1v1DAQQCMEoqVw4I6QpV7gELATJ7aPy6q0KxVRFThbjj3Zekni1B-H_B9-KC5bckBcPPb4-WnGdlG8JvgDIY34iDGmnAhGnxSnhFakFIzxp3mOSVNywdlJ8SKEA85LJqrnxUklcN1w1p4Wv64W490eJnSpAtrECFNSEQL6sjitvLFqQLug72C0Ct3CDL5PwboJ7aZD8ksOJifzMEXkenTjQtRuMjZmxk57ZCd0q2JA3bLKH9IXk3HzoMJodbZGq9OQRvQtegihzM6kwaBNim6-U_vlZfGsV0OAV4_xrPjx-eL79qq8_nq5226uS91UIpZU1IbWWrdK9Vh3vKMMtyrvmZZ1XZ97FlXX4aZVLTasAwU834HgQAW0hEN9VuyOXuPUQc7ejsov0ikr_ySc30vlc7EDyL7vSYVJB6zFtIE2a2ld60oLUVdE0Ox6d3TN3t0nCFGONmgYBjWBS0ES0VQEY055Rs__QQ8u-Sl3KitCGKEtZU2m3h8p7V0IHvq1QILlwzeQ6zfI7NtHY-pGMCv5990z8OYI_FR-D34F1vPn_93e3nw6EnI2ff0byEPD_w</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2117146475</pqid></control><display><type>article</type><title>Hydrogen Gas Attenuates Myocardial Ischemia Reperfusion Injury Independent of Postconditioning in Rats by Attenuating Endoplasmic Reticulum Stress-Induced Autophagy</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Karger Open Access</source><creator>Gao, Yunan ; Yang, Hongxiao ; Chi, Jing ; Xu, Qiannan ; Zhao, Luqi ; Yang, Weijia ; Liu, Weifan ; Yang, Wei</creator><creatorcontrib>Gao, Yunan ; Yang, Hongxiao ; Chi, Jing ; Xu, Qiannan ; Zhao, Luqi ; Yang, Weijia ; Liu, Weifan ; Yang, Wei</creatorcontrib><description>Background/Aims: To study the effect of inhaling hydrogen gas on myocardial ischemic/reperfusion(I/R) injury in rats. Methods: Seventy male Wistar albino rats were divided into five groups at random as the sham group (Sham). The I/R group (I/R), The ischemic postconditioning group (IPo), The I/R plus hydrogen group (IH 2 ) and the ischemic postconditioning plus hydrogen group (IPoH 2 ). The Sham group was without coronary occlusion. In I/R group, Ischemic/reperfusion injury was induced by coronary occlusion for 1 hour. Followed by 2 hours of reperfusion. In the IPo and IPoH2 group, four cycles of 1 min reperfusion/1 min ischemia was given at the end of 1 hour coronary occlusion. While 2% hydrogen was administered by inhalation 5 min before reperfusion till 2 hours after reperfusion in both the IPoH2 and IH2 group. The heart and blood samples were harvested at the end of the surgical protocol. Then the myocardium cell endoplasmic reticulum(ER) stress and autophagy was observed by electron microscope. In addition, the cardiac ER stress and autophagy related proteins expression were detected by Western blotting analysis. Results: Both inhaling 2% hydrogen and ischemic postconditioning treatment reduced the ischemic size and serum troponin I level in rats with I/R injury, and inhaling hydrogen showed a more curative effect compared with ischemic postconditioning treatment. Meanwhile inhaling hydrogen showed a better protective effect in attenuating tissue reactive oxygen species. Malondialdehyde levels and immunoreactivities against 8-hydroxy-2’-deoxyguanosine and inhibiting cardiac endoplasmic reticulum stress and down-regulating autophagy as compared with ischemic postconditioning treatment. Conclusion: These results revealed a better protective effect of hydrogen on myocardial ischemic/reperfusion injury in rats by attenuating endoplasmic reticulum stress and down-regulating autophagy compared with ischemic postconditioning treatment.</description><identifier>ISSN: 1015-8987</identifier><identifier>EISSN: 1421-9778</identifier><identifier>DOI: 10.1159/000481974</identifier><identifier>PMID: 29035876</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Animals ; Apoptosis ; Autophagy ; Autophagy - drug effects ; Cytotoxicity ; Endoplasmic reticulum ; Endoplasmic reticulum stress ; Endoplasmic Reticulum Stress - drug effects ; Heart attacks ; Hospitals ; Hydrogen ; Hydrogen - therapeutic use ; Ischemia ; Ischemic Postconditioning ; Ischemic/reperfusion injury ; Kinases ; Laboratory animals ; Male ; Metabolism ; Myocardial Reperfusion Injury - pathology ; Myocardial Reperfusion Injury - therapy ; Myocardium - pathology ; Original Paper ; Oxidative stress ; Proteins ; Rats, Wistar ; Rodents ; Ventilation</subject><ispartof>Cellular physiology and biochemistry, 2017-01, Vol.43 (4), p.1503-1514</ispartof><rights>2017 The Author(s). Published by S. Karger AG, Basel</rights><rights>2017 The Author(s). Published by S. Karger AG, Basel.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c529t-493d43cc6aaf0cb8b4706ac52d67bbf90392bb056a60d7beae887698e49e618e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,865,2103,27640,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29035876$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gao, Yunan</creatorcontrib><creatorcontrib>Yang, Hongxiao</creatorcontrib><creatorcontrib>Chi, Jing</creatorcontrib><creatorcontrib>Xu, Qiannan</creatorcontrib><creatorcontrib>Zhao, Luqi</creatorcontrib><creatorcontrib>Yang, Weijia</creatorcontrib><creatorcontrib>Liu, Weifan</creatorcontrib><creatorcontrib>Yang, Wei</creatorcontrib><title>Hydrogen Gas Attenuates Myocardial Ischemia Reperfusion Injury Independent of Postconditioning in Rats by Attenuating Endoplasmic Reticulum Stress-Induced Autophagy</title><title>Cellular physiology and biochemistry</title><addtitle>Cell Physiol Biochem</addtitle><description>Background/Aims: To study the effect of inhaling hydrogen gas on myocardial ischemic/reperfusion(I/R) injury in rats. Methods: Seventy male Wistar albino rats were divided into five groups at random as the sham group (Sham). The I/R group (I/R), The ischemic postconditioning group (IPo), The I/R plus hydrogen group (IH 2 ) and the ischemic postconditioning plus hydrogen group (IPoH 2 ). The Sham group was without coronary occlusion. In I/R group, Ischemic/reperfusion injury was induced by coronary occlusion for 1 hour. Followed by 2 hours of reperfusion. In the IPo and IPoH2 group, four cycles of 1 min reperfusion/1 min ischemia was given at the end of 1 hour coronary occlusion. While 2% hydrogen was administered by inhalation 5 min before reperfusion till 2 hours after reperfusion in both the IPoH2 and IH2 group. The heart and blood samples were harvested at the end of the surgical protocol. Then the myocardium cell endoplasmic reticulum(ER) stress and autophagy was observed by electron microscope. In addition, the cardiac ER stress and autophagy related proteins expression were detected by Western blotting analysis. Results: Both inhaling 2% hydrogen and ischemic postconditioning treatment reduced the ischemic size and serum troponin I level in rats with I/R injury, and inhaling hydrogen showed a more curative effect compared with ischemic postconditioning treatment. Meanwhile inhaling hydrogen showed a better protective effect in attenuating tissue reactive oxygen species. Malondialdehyde levels and immunoreactivities against 8-hydroxy-2’-deoxyguanosine and inhibiting cardiac endoplasmic reticulum stress and down-regulating autophagy as compared with ischemic postconditioning treatment. Conclusion: These results revealed a better protective effect of hydrogen on myocardial ischemic/reperfusion injury in rats by attenuating endoplasmic reticulum stress and down-regulating autophagy compared with ischemic postconditioning treatment.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Autophagy</subject><subject>Autophagy - drug effects</subject><subject>Cytotoxicity</subject><subject>Endoplasmic reticulum</subject><subject>Endoplasmic reticulum stress</subject><subject>Endoplasmic Reticulum Stress - drug effects</subject><subject>Heart attacks</subject><subject>Hospitals</subject><subject>Hydrogen</subject><subject>Hydrogen - therapeutic use</subject><subject>Ischemia</subject><subject>Ischemic Postconditioning</subject><subject>Ischemic/reperfusion injury</subject><subject>Kinases</subject><subject>Laboratory animals</subject><subject>Male</subject><subject>Metabolism</subject><subject>Myocardial Reperfusion Injury - pathology</subject><subject>Myocardial Reperfusion Injury - therapy</subject><subject>Myocardium - pathology</subject><subject>Original Paper</subject><subject>Oxidative stress</subject><subject>Proteins</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Ventilation</subject><issn>1015-8987</issn><issn>1421-9778</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DOA</sourceid><recordid>eNptkk1v1DAQQCMEoqVw4I6QpV7gELATJ7aPy6q0KxVRFThbjj3Zekni1B-H_B9-KC5bckBcPPb4-WnGdlG8JvgDIY34iDGmnAhGnxSnhFakFIzxp3mOSVNywdlJ8SKEA85LJqrnxUklcN1w1p4Wv64W490eJnSpAtrECFNSEQL6sjitvLFqQLug72C0Ct3CDL5PwboJ7aZD8ksOJifzMEXkenTjQtRuMjZmxk57ZCd0q2JA3bLKH9IXk3HzoMJodbZGq9OQRvQtegihzM6kwaBNim6-U_vlZfGsV0OAV4_xrPjx-eL79qq8_nq5226uS91UIpZU1IbWWrdK9Vh3vKMMtyrvmZZ1XZ97FlXX4aZVLTasAwU834HgQAW0hEN9VuyOXuPUQc7ejsov0ikr_ySc30vlc7EDyL7vSYVJB6zFtIE2a2ld60oLUVdE0Ox6d3TN3t0nCFGONmgYBjWBS0ES0VQEY055Rs__QQ8u-Sl3KitCGKEtZU2m3h8p7V0IHvq1QILlwzeQ6zfI7NtHY-pGMCv5990z8OYI_FR-D34F1vPn_93e3nw6EnI2ff0byEPD_w</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Gao, Yunan</creator><creator>Yang, Hongxiao</creator><creator>Chi, Jing</creator><creator>Xu, Qiannan</creator><creator>Zhao, Luqi</creator><creator>Yang, Weijia</creator><creator>Liu, Weifan</creator><creator>Yang, Wei</creator><general>S. Karger AG</general><general>Cell Physiol Biochem Press GmbH & Co KG</general><scope>M--</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>20170101</creationdate><title>Hydrogen Gas Attenuates Myocardial Ischemia Reperfusion Injury Independent of Postconditioning in Rats by Attenuating Endoplasmic Reticulum Stress-Induced Autophagy</title><author>Gao, Yunan ; Yang, Hongxiao ; Chi, Jing ; Xu, Qiannan ; Zhao, Luqi ; Yang, Weijia ; Liu, Weifan ; Yang, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-493d43cc6aaf0cb8b4706ac52d67bbf90392bb056a60d7beae887698e49e618e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Autophagy</topic><topic>Autophagy - drug effects</topic><topic>Cytotoxicity</topic><topic>Endoplasmic reticulum</topic><topic>Endoplasmic reticulum stress</topic><topic>Endoplasmic Reticulum Stress - drug effects</topic><topic>Heart attacks</topic><topic>Hospitals</topic><topic>Hydrogen</topic><topic>Hydrogen - therapeutic use</topic><topic>Ischemia</topic><topic>Ischemic Postconditioning</topic><topic>Ischemic/reperfusion injury</topic><topic>Kinases</topic><topic>Laboratory animals</topic><topic>Male</topic><topic>Metabolism</topic><topic>Myocardial Reperfusion Injury - pathology</topic><topic>Myocardial Reperfusion Injury - therapy</topic><topic>Myocardium - pathology</topic><topic>Original Paper</topic><topic>Oxidative stress</topic><topic>Proteins</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Ventilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gao, Yunan</creatorcontrib><creatorcontrib>Yang, Hongxiao</creatorcontrib><creatorcontrib>Chi, Jing</creatorcontrib><creatorcontrib>Xu, Qiannan</creatorcontrib><creatorcontrib>Zhao, Luqi</creatorcontrib><creatorcontrib>Yang, Weijia</creatorcontrib><creatorcontrib>Liu, Weifan</creatorcontrib><creatorcontrib>Yang, Wei</creatorcontrib><collection>Karger Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Cellular physiology and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gao, Yunan</au><au>Yang, Hongxiao</au><au>Chi, Jing</au><au>Xu, Qiannan</au><au>Zhao, Luqi</au><au>Yang, Weijia</au><au>Liu, Weifan</au><au>Yang, Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hydrogen Gas Attenuates Myocardial Ischemia Reperfusion Injury Independent of Postconditioning in Rats by Attenuating Endoplasmic Reticulum Stress-Induced Autophagy</atitle><jtitle>Cellular physiology and biochemistry</jtitle><addtitle>Cell Physiol Biochem</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>43</volume><issue>4</issue><spage>1503</spage><epage>1514</epage><pages>1503-1514</pages><issn>1015-8987</issn><eissn>1421-9778</eissn><abstract>Background/Aims: To study the effect of inhaling hydrogen gas on myocardial ischemic/reperfusion(I/R) injury in rats. Methods: Seventy male Wistar albino rats were divided into five groups at random as the sham group (Sham). The I/R group (I/R), The ischemic postconditioning group (IPo), The I/R plus hydrogen group (IH 2 ) and the ischemic postconditioning plus hydrogen group (IPoH 2 ). The Sham group was without coronary occlusion. In I/R group, Ischemic/reperfusion injury was induced by coronary occlusion for 1 hour. Followed by 2 hours of reperfusion. In the IPo and IPoH2 group, four cycles of 1 min reperfusion/1 min ischemia was given at the end of 1 hour coronary occlusion. While 2% hydrogen was administered by inhalation 5 min before reperfusion till 2 hours after reperfusion in both the IPoH2 and IH2 group. The heart and blood samples were harvested at the end of the surgical protocol. Then the myocardium cell endoplasmic reticulum(ER) stress and autophagy was observed by electron microscope. In addition, the cardiac ER stress and autophagy related proteins expression were detected by Western blotting analysis. Results: Both inhaling 2% hydrogen and ischemic postconditioning treatment reduced the ischemic size and serum troponin I level in rats with I/R injury, and inhaling hydrogen showed a more curative effect compared with ischemic postconditioning treatment. Meanwhile inhaling hydrogen showed a better protective effect in attenuating tissue reactive oxygen species. Malondialdehyde levels and immunoreactivities against 8-hydroxy-2’-deoxyguanosine and inhibiting cardiac endoplasmic reticulum stress and down-regulating autophagy as compared with ischemic postconditioning treatment. Conclusion: These results revealed a better protective effect of hydrogen on myocardial ischemic/reperfusion injury in rats by attenuating endoplasmic reticulum stress and down-regulating autophagy compared with ischemic postconditioning treatment.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>29035876</pmid><doi>10.1159/000481974</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Apoptosis Autophagy Autophagy - drug effects Cytotoxicity Endoplasmic reticulum Endoplasmic reticulum stress Endoplasmic Reticulum Stress - drug effects Heart attacks Hospitals Hydrogen Hydrogen - therapeutic use Ischemia Ischemic Postconditioning Ischemic/reperfusion injury Kinases Laboratory animals Male Metabolism Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - therapy Myocardium - pathology Original Paper Oxidative stress Proteins Rats, Wistar Rodents Ventilation |
| title | Hydrogen Gas Attenuates Myocardial Ischemia Reperfusion Injury Independent of Postconditioning in Rats by Attenuating Endoplasmic Reticulum Stress-Induced Autophagy |
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