Immunomodulatory activity of Lactobacillus plantarum KLDS1.0318 in cyclophosphamide-treated mice
Background: Probiotics in fermented foods have attracted considerable attention lately as treatment options for immune diseases, the incidence of which has been increasing throughout the world. Objective: The objective of the present study was to investigate the immunomodulatory activity of Lactobac...
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| Veröffentlicht in: | Food & nutrition research 2018-01, Vol.62, p.1-9 |
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| creator | Meng, Yueyue Li, Bailiang Jin, Da Zhan, Meng Lu, Jingjing Huo, Guicheng |
| description | Background: Probiotics in fermented foods have attracted considerable attention lately as treatment options for immune diseases, the incidence of which has been increasing throughout the world. Objective: The objective of the present study was to investigate the immunomodulatory activity of Lactobacillus plantarum (L. plantarum) KLDS1.0318 in cyclophosphamide-treated mice. Design: To investigate the immune-enhancing effects of L. plantarum KLDS1.0318, we used a immunosuppressive model. Ninety female six-week-old BALB/c mice were randomly divided into six groups: normal control (NC) group, model control (MC) group, immunosuppression plus L. plantarum KLDS1.0318 groups with three different doses (KLDS1.0318-L, KLDS1.0318-M, and KLDS1.0318-H), and plus levamisole hydrochloride as positive control (PC) group. Results and discussions: Results showed that the thymus and spleen indexes of the four treatment groups were significantly higher than those of the MC group (2.01±0.16) ( p < 0.05). The capacity of lymphocyte proliferation, the activity of natural killer (NK) cell and macrophages phagocytosis were significantly increased ( p < 0.05) in four treatment groups as compared with the MC group (0.327±0.022, 62.29±0.8, 0.087±0.008, respectively). The levels of relative immune factors (IL-2, IL-6, and IFN-γ) showed similar patterns ( p < 0.05). Conclusions: This study suggested that orally administered L.plantarum KLDS1.0318 may effectively accelerate the recovery of immunosuppressive mice caused by cyclophosphamide (CTX). The immunomodulatory activity of the srtain recommended that L. plantarum KLDS1.0318 could be used as a powerful medicinal treatment against immunosuppression. |
| doi_str_mv | 10.29219/fnrv62.1296 |
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| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_2116802942</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2116802942</sourcerecordid><originalsourceid>FETCH-proquest_journals_21168029423</originalsourceid><addsrcrecordid>eNqNir1uwjAYAC0kpFLoxgNYYk7qz0mtZIaiorLRoRu4jiOMbH_BP0h5exj6AEyn0x0hS2Albzm0770PN8FL4K2YkBmIj7oQAn5fyGuMF8ZExZp6Rk4757JHh122MmEYqVTJ3EwaKfZ0_xD8k8pYmyMdrPRJhuzo935zgJJV0FDjqRqVxeGMcThLZzpdpKBl0h11RukFmfbSRv32zzlZbT9_1l_FEPCadUzHC-bgH-nIAUTDeFvz6rnrDhmKSWU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2116802942</pqid></control><display><type>article</type><title>Immunomodulatory activity of Lactobacillus plantarum KLDS1.0318 in cyclophosphamide-treated mice</title><source>Co-Action Open Access Journals</source><source>Directory of Open Access Journals</source><source>Norart Open Access</source><source>PubMed Central</source><source>EZB Electronic Journals Library</source><creator>Meng, Yueyue ; Li, Bailiang ; Jin, Da ; Zhan, Meng ; Lu, Jingjing ; Huo, Guicheng</creator><creatorcontrib>Meng, Yueyue ; Li, Bailiang ; Jin, Da ; Zhan, Meng ; Lu, Jingjing ; Huo, Guicheng</creatorcontrib><description>Background: Probiotics in fermented foods have attracted considerable attention lately as treatment options for immune diseases, the incidence of which has been increasing throughout the world. Objective: The objective of the present study was to investigate the immunomodulatory activity of Lactobacillus plantarum (L. plantarum) KLDS1.0318 in cyclophosphamide-treated mice. Design: To investigate the immune-enhancing effects of L. plantarum KLDS1.0318, we used a immunosuppressive model. Ninety female six-week-old BALB/c mice were randomly divided into six groups: normal control (NC) group, model control (MC) group, immunosuppression plus L. plantarum KLDS1.0318 groups with three different doses (KLDS1.0318-L, KLDS1.0318-M, and KLDS1.0318-H), and plus levamisole hydrochloride as positive control (PC) group. Results and discussions: Results showed that the thymus and spleen indexes of the four treatment groups were significantly higher than those of the MC group (2.01±0.16) ( p < 0.05). The capacity of lymphocyte proliferation, the activity of natural killer (NK) cell and macrophages phagocytosis were significantly increased ( p < 0.05) in four treatment groups as compared with the MC group (0.327±0.022, 62.29±0.8, 0.087±0.008, respectively). The levels of relative immune factors (IL-2, IL-6, and IFN-γ) showed similar patterns ( p < 0.05). Conclusions: This study suggested that orally administered L.plantarum KLDS1.0318 may effectively accelerate the recovery of immunosuppressive mice caused by cyclophosphamide (CTX). The immunomodulatory activity of the srtain recommended that L. plantarum KLDS1.0318 could be used as a powerful medicinal treatment against immunosuppression.</description><identifier>EISSN: 1654-661X</identifier><identifier>DOI: 10.29219/fnrv62.1296</identifier><language>eng</language><publisher>Abingdon: Swedish Nutrition Foundation, SNF</publisher><subject>Acne ; Bacteria ; Cyclophosphamide ; Cytokines ; Fermented food ; Immune system ; Immunological diseases ; Immunomodulation ; Immunomodulators ; Immunosuppression ; Infections ; Interleukin 2 ; Interleukin 6 ; Laboratory animals ; Lactobacillus plantarum ; Levamisole ; Lymphocytes ; Macrophages ; Medicinal plants ; Mice ; Natural killer cells ; Oral administration ; Phagocytosis ; Probiotics ; Rodents ; Spleen ; Thymus ; γ-Interferon</subject><ispartof>Food & nutrition research, 2018-01, Vol.62, p.1-9</ispartof><rights>2018. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids></links><search><creatorcontrib>Meng, Yueyue</creatorcontrib><creatorcontrib>Li, Bailiang</creatorcontrib><creatorcontrib>Jin, Da</creatorcontrib><creatorcontrib>Zhan, Meng</creatorcontrib><creatorcontrib>Lu, Jingjing</creatorcontrib><creatorcontrib>Huo, Guicheng</creatorcontrib><title>Immunomodulatory activity of Lactobacillus plantarum KLDS1.0318 in cyclophosphamide-treated mice</title><title>Food & nutrition research</title><description>Background: Probiotics in fermented foods have attracted considerable attention lately as treatment options for immune diseases, the incidence of which has been increasing throughout the world. Objective: The objective of the present study was to investigate the immunomodulatory activity of Lactobacillus plantarum (L. plantarum) KLDS1.0318 in cyclophosphamide-treated mice. Design: To investigate the immune-enhancing effects of L. plantarum KLDS1.0318, we used a immunosuppressive model. Ninety female six-week-old BALB/c mice were randomly divided into six groups: normal control (NC) group, model control (MC) group, immunosuppression plus L. plantarum KLDS1.0318 groups with three different doses (KLDS1.0318-L, KLDS1.0318-M, and KLDS1.0318-H), and plus levamisole hydrochloride as positive control (PC) group. Results and discussions: Results showed that the thymus and spleen indexes of the four treatment groups were significantly higher than those of the MC group (2.01±0.16) ( p < 0.05). The capacity of lymphocyte proliferation, the activity of natural killer (NK) cell and macrophages phagocytosis were significantly increased ( p < 0.05) in four treatment groups as compared with the MC group (0.327±0.022, 62.29±0.8, 0.087±0.008, respectively). The levels of relative immune factors (IL-2, IL-6, and IFN-γ) showed similar patterns ( p < 0.05). Conclusions: This study suggested that orally administered L.plantarum KLDS1.0318 may effectively accelerate the recovery of immunosuppressive mice caused by cyclophosphamide (CTX). The immunomodulatory activity of the srtain recommended that L. plantarum KLDS1.0318 could be used as a powerful medicinal treatment against immunosuppression.</description><subject>Acne</subject><subject>Bacteria</subject><subject>Cyclophosphamide</subject><subject>Cytokines</subject><subject>Fermented food</subject><subject>Immune system</subject><subject>Immunological diseases</subject><subject>Immunomodulation</subject><subject>Immunomodulators</subject><subject>Immunosuppression</subject><subject>Infections</subject><subject>Interleukin 2</subject><subject>Interleukin 6</subject><subject>Laboratory animals</subject><subject>Lactobacillus plantarum</subject><subject>Levamisole</subject><subject>Lymphocytes</subject><subject>Macrophages</subject><subject>Medicinal plants</subject><subject>Mice</subject><subject>Natural killer cells</subject><subject>Oral administration</subject><subject>Phagocytosis</subject><subject>Probiotics</subject><subject>Rodents</subject><subject>Spleen</subject><subject>Thymus</subject><subject>γ-Interferon</subject><issn>1654-661X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqNir1uwjAYAC0kpFLoxgNYYk7qz0mtZIaiorLRoRu4jiOMbH_BP0h5exj6AEyn0x0hS2Albzm0770PN8FL4K2YkBmIj7oQAn5fyGuMF8ZExZp6Rk4757JHh122MmEYqVTJ3EwaKfZ0_xD8k8pYmyMdrPRJhuzo935zgJJV0FDjqRqVxeGMcThLZzpdpKBl0h11RukFmfbSRv32zzlZbT9_1l_FEPCadUzHC-bgH-nIAUTDeFvz6rnrDhmKSWU</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Meng, Yueyue</creator><creator>Li, Bailiang</creator><creator>Jin, Da</creator><creator>Zhan, Meng</creator><creator>Lu, Jingjing</creator><creator>Huo, Guicheng</creator><general>Swedish Nutrition Foundation, SNF</general><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T7</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20180101</creationdate><title>Immunomodulatory activity of Lactobacillus plantarum KLDS1.0318 in cyclophosphamide-treated mice</title><author>Meng, Yueyue ; Li, Bailiang ; Jin, Da ; Zhan, Meng ; Lu, Jingjing ; Huo, Guicheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_21168029423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Acne</topic><topic>Bacteria</topic><topic>Cyclophosphamide</topic><topic>Cytokines</topic><topic>Fermented food</topic><topic>Immune system</topic><topic>Immunological diseases</topic><topic>Immunomodulation</topic><topic>Immunomodulators</topic><topic>Immunosuppression</topic><topic>Infections</topic><topic>Interleukin 2</topic><topic>Interleukin 6</topic><topic>Laboratory animals</topic><topic>Lactobacillus plantarum</topic><topic>Levamisole</topic><topic>Lymphocytes</topic><topic>Macrophages</topic><topic>Medicinal plants</topic><topic>Mice</topic><topic>Natural killer cells</topic><topic>Oral administration</topic><topic>Phagocytosis</topic><topic>Probiotics</topic><topic>Rodents</topic><topic>Spleen</topic><topic>Thymus</topic><topic>γ-Interferon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meng, Yueyue</creatorcontrib><creatorcontrib>Li, Bailiang</creatorcontrib><creatorcontrib>Jin, Da</creatorcontrib><creatorcontrib>Zhan, Meng</creatorcontrib><creatorcontrib>Lu, Jingjing</creatorcontrib><creatorcontrib>Huo, Guicheng</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Food & nutrition research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meng, Yueyue</au><au>Li, Bailiang</au><au>Jin, Da</au><au>Zhan, Meng</au><au>Lu, Jingjing</au><au>Huo, Guicheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunomodulatory activity of Lactobacillus plantarum KLDS1.0318 in cyclophosphamide-treated mice</atitle><jtitle>Food & nutrition research</jtitle><date>2018-01-01</date><risdate>2018</risdate><volume>62</volume><spage>1</spage><epage>9</epage><pages>1-9</pages><eissn>1654-661X</eissn><abstract>Background: Probiotics in fermented foods have attracted considerable attention lately as treatment options for immune diseases, the incidence of which has been increasing throughout the world. Objective: The objective of the present study was to investigate the immunomodulatory activity of Lactobacillus plantarum (L. plantarum) KLDS1.0318 in cyclophosphamide-treated mice. Design: To investigate the immune-enhancing effects of L. plantarum KLDS1.0318, we used a immunosuppressive model. Ninety female six-week-old BALB/c mice were randomly divided into six groups: normal control (NC) group, model control (MC) group, immunosuppression plus L. plantarum KLDS1.0318 groups with three different doses (KLDS1.0318-L, KLDS1.0318-M, and KLDS1.0318-H), and plus levamisole hydrochloride as positive control (PC) group. Results and discussions: Results showed that the thymus and spleen indexes of the four treatment groups were significantly higher than those of the MC group (2.01±0.16) ( p < 0.05). The capacity of lymphocyte proliferation, the activity of natural killer (NK) cell and macrophages phagocytosis were significantly increased ( p < 0.05) in four treatment groups as compared with the MC group (0.327±0.022, 62.29±0.8, 0.087±0.008, respectively). The levels of relative immune factors (IL-2, IL-6, and IFN-γ) showed similar patterns ( p < 0.05). Conclusions: This study suggested that orally administered L.plantarum KLDS1.0318 may effectively accelerate the recovery of immunosuppressive mice caused by cyclophosphamide (CTX). The immunomodulatory activity of the srtain recommended that L. plantarum KLDS1.0318 could be used as a powerful medicinal treatment against immunosuppression.</abstract><cop>Abingdon</cop><pub>Swedish Nutrition Foundation, SNF</pub><doi>10.29219/fnrv62.1296</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Acne Bacteria Cyclophosphamide Cytokines Fermented food Immune system Immunological diseases Immunomodulation Immunomodulators Immunosuppression Infections Interleukin 2 Interleukin 6 Laboratory animals Lactobacillus plantarum Levamisole Lymphocytes Macrophages Medicinal plants Mice Natural killer cells Oral administration Phagocytosis Probiotics Rodents Spleen Thymus γ-Interferon |
| title | Immunomodulatory activity of Lactobacillus plantarum KLDS1.0318 in cyclophosphamide-treated mice |
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