Non-Enzymatic and Site-Specific Glycan Shedding: A Novel Protein Degradation Pathway Observed in a Stabilized Form of RSV Prefusion F Protein

Stability is one of the critical attributes of a protein-based therapeutic or vaccine product, which is directly linked to product quality and efficacy. Elucidating protein degradation pathways is required to obtain thorough understanding of the product and ensure degradation products are properly m...

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Veröffentlicht in:Analytical chemistry (Washington) 2018-09, Vol.90 (18), p.10897-10902
Hauptverfasser: Qian, Jiang, Yearley, Eric, Tian, Sai, Jing, Li, Balsaraf, Ankita, Lo Surdo, Paola, Huang, Ying, Chandramouli, Sumana, Bottomley, Matthew J, Moniotte, Nicolas, Wang, Zihao
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Sprache:eng
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