The Independent and Combined Effects of Omega-3 and Vitamin B12 in Ameliorating Propionic Acid Induced Biochemical Features in Juvenile Rats as Rodent Model of Autism

Metabolites of proper fatty acids modulate the inflammatory response and are essential for normal brain development; equally, abnormal fatty acid metabolism plays a critical role in the pathology of autism. Currently, dietary supplements are often used to improve the core symptoms of Autism spectrum...

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Veröffentlicht in:	Journal of molecular neuroscience 2018-11, Vol.66 (3), p.403-413
Hauptverfasser:	Alfawaz, Hanan, Al-Onazi, Mona, Bukhari, Sarah I., Binobead, Manal, Othman, Nashwa, Algahtani, Norah, Bhat, Ramesa Shafi, Moubayed, Nadine M. S., Alzeer, Haya S., El-Ansary, Afaf
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - administration & dosage Antioxidants - pharmacology Antioxidants - therapeutic use Arachidonate 5-lipoxygenase Autism Autistic Disorder - etiology Autistic Disorder - metabolism Autistic Disorder - prevention & control Biomedical and Life Sciences Biomedicine Body weight Brain Brain - drug effects Brain - growth & development Brain - metabolism Cell Biology Cyanocobalamin Cyclooxygenase-2 Diet Dietary supplements Fatty acids Fatty Acids, Omega-3 - administration & dosage Fatty Acids, Omega-3 - pharmacology Fatty Acids, Omega-3 - therapeutic use Gastrointestinal Microbiome - drug effects Glutathione Glutathione transferase Inflammation Inflammatory response Intestinal microflora Lipid Metabolism Lipids Lipoxygenase Liquid oxygen Male Metabolic pathways Metabolism Metabolites Microbiota Microorganisms Neurochemistry Neurology Neurosciences Neurotoxicity Oxidative stress Peroxides Polyunsaturated fatty acids Propionates - toxicity Propionic acid Proteomics Rats Rodents Strains (organisms) Vitamin B 12 - administration & dosage Vitamin B 12 - pharmacology Vitamin B 12 - therapeutic use Vitamin B12 Vitamins - administration & dosage Vitamins - pharmacology Vitamins - therapeutic use
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