The magnetic graphene-based nanocomposite: An efficient anticancer delivery system
The aim of this study is the development of an efficient anticancer drug delivery nanosystem using PEGylated graphene oxide/magnetite nanoparticles (PEG-GO/Fe3O4). The nanosystem was loaded with mitoxantrone (MTX) as a universal anticancer drug. The cytotoxicity effect of the MTX-loaded GO-PEG/Fe3O4...
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| creator | Jafarizad, Abbas Jaymand, Mehdi Taghizadehghalehjougi, Ali Mohammadi-Nasr, Saeed Jabbari, Amir Mohammad |
| description | The aim of this study is the development of an efficient anticancer drug delivery nanosystem using PEGylated graphene oxide/magnetite nanoparticles (PEG-GO/Fe3O4). The nanosystem was loaded with mitoxantrone (MTX) as a universal anticancer drug. The cytotoxicity effect of the MTX-loaded GO-PEG/Fe3O4 nanocomposite was studied against U87 MG cell line using MTT cell viablity assay. The mechanism of action, the genes contributed in apoptosis (Casp 9, and Casp 3) and survival (BcL-2, BAX) have been investigated using quantitative real time-PCR. As the results of biological assays, controlled drug release behavior of the developed nanosystem as well as the inherent physicochemical and biological characteristics of both magnetit nanoparticles and graphene nanomaterials, we envision that the GO-PEG/Fe3O4 nanocomposite may be applied as enhanced drug delivery system for various cancer therapies (e.g., brain cancer) using both chemo- and photothermal therapy methods. |
| doi_str_mv | 10.1063/1.5018971 |
| format | Conference Proceeding |
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| fulltext | fulltext |
| identifier | ISSN: 0094-243X |
| ispartof | AIP conference proceedings, 2018, Vol.1920 (1) |
| issn | 0094-243X 1551-7616 |
| language | eng |
| recordid | cdi_proquest_journals_2115810758 |
| source | AIP Journals Complete |
| subjects | Anticancer properties Apoptosis Biological effects Brain Cancer Drug delivery systems Graphene Iron oxides Nanocomposites Nanomaterials Nanoparticles Toxicity |
| title | The magnetic graphene-based nanocomposite: An efficient anticancer delivery system |
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