Crosslinked gelatin hydrogels as carriers for controlled heparin release
[Display omitted] •Crosslinked gelatin hydrogel for sustained release of heparin.•The release can be tailored to the needs by varying hydrogel crosslinking degree.•Lower platelets adhesion on heparin-loaded hydrogels.•Possible application as coating in catheters and cardiovascular devices. The appli...
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| Veröffentlicht in: | Materials letters 2018-10, Vol.228, p.375-378 |
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| creator | Gritsch, Lukas Motta, Federico L. Contessi Negrini, Nicola Yahia, L'Hocine Farè, Silvia |
| description | [Display omitted]
•Crosslinked gelatin hydrogel for sustained release of heparin.•The release can be tailored to the needs by varying hydrogel crosslinking degree.•Lower platelets adhesion on heparin-loaded hydrogels.•Possible application as coating in catheters and cardiovascular devices.
The application of heparin as anticoagulant, anti-inflammatory and growth factor regulating agent is currently limited by its narrow therapeutic window. Here, we describe the use of chemically crosslinked gelatin hydrogels as delivery platform to achieve the control of heparin release over time. Different hydrogel formulations and two strategies for heparin loading were tested. The synergic electrostatic interactions between heparin and gelatin hydrogels resulted in a sustained release until 60 h, demonstrated by toluidine blue tests. Platelets adhesion was significantly reduced in heparin-loaded hydrogels, thus proving good heparin bioactivity after processing. Our heparin-loaded hydrogels represent a possible valid option to develop coating for catheters and cardiovascular devices, or skin dressings. |
| doi_str_mv | 10.1016/j.matlet.2018.06.047 |
| format | Article |
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•Crosslinked gelatin hydrogel for sustained release of heparin.•The release can be tailored to the needs by varying hydrogel crosslinking degree.•Lower platelets adhesion on heparin-loaded hydrogels.•Possible application as coating in catheters and cardiovascular devices.
The application of heparin as anticoagulant, anti-inflammatory and growth factor regulating agent is currently limited by its narrow therapeutic window. Here, we describe the use of chemically crosslinked gelatin hydrogels as delivery platform to achieve the control of heparin release over time. Different hydrogel formulations and two strategies for heparin loading were tested. The synergic electrostatic interactions between heparin and gelatin hydrogels resulted in a sustained release until 60 h, demonstrated by toluidine blue tests. Platelets adhesion was significantly reduced in heparin-loaded hydrogels, thus proving good heparin bioactivity after processing. Our heparin-loaded hydrogels represent a possible valid option to develop coating for catheters and cardiovascular devices, or skin dressings.</description><identifier>ISSN: 0167-577X</identifier><identifier>EISSN: 1873-4979</identifier><identifier>DOI: 10.1016/j.matlet.2018.06.047</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adhesion tests ; Anticoagulant ; Anticoagulants ; Catheters ; Crosslinking ; Crosslinking polymerization ; Formulations ; Gelatin ; Gelatin hydrogel ; Growth factors ; Heparin ; Hydrogels ; Materials science ; Organic chemistry ; Platelets ; Platelets adhesion ; Sustained release ; Therapeutic agent ; Toluidine blue</subject><ispartof>Materials letters, 2018-10, Vol.228, p.375-378</ispartof><rights>2018 Elsevier B.V.</rights><rights>Copyright Elsevier BV Oct 1, 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c334t-1a08f6a248de0d940190bb7c187e18cbf3d15d16a1662b7522f2cd127e4555643</citedby><cites>FETCH-LOGICAL-c334t-1a08f6a248de0d940190bb7c187e18cbf3d15d16a1662b7522f2cd127e4555643</cites><orcidid>0000-0003-3719-8869 ; 0000-0002-0303-1131</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0167577X18309522$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids></links><search><creatorcontrib>Gritsch, Lukas</creatorcontrib><creatorcontrib>Motta, Federico L.</creatorcontrib><creatorcontrib>Contessi Negrini, Nicola</creatorcontrib><creatorcontrib>Yahia, L'Hocine</creatorcontrib><creatorcontrib>Farè, Silvia</creatorcontrib><title>Crosslinked gelatin hydrogels as carriers for controlled heparin release</title><title>Materials letters</title><description>[Display omitted]
•Crosslinked gelatin hydrogel for sustained release of heparin.•The release can be tailored to the needs by varying hydrogel crosslinking degree.•Lower platelets adhesion on heparin-loaded hydrogels.•Possible application as coating in catheters and cardiovascular devices.
The application of heparin as anticoagulant, anti-inflammatory and growth factor regulating agent is currently limited by its narrow therapeutic window. Here, we describe the use of chemically crosslinked gelatin hydrogels as delivery platform to achieve the control of heparin release over time. Different hydrogel formulations and two strategies for heparin loading were tested. The synergic electrostatic interactions between heparin and gelatin hydrogels resulted in a sustained release until 60 h, demonstrated by toluidine blue tests. Platelets adhesion was significantly reduced in heparin-loaded hydrogels, thus proving good heparin bioactivity after processing. Our heparin-loaded hydrogels represent a possible valid option to develop coating for catheters and cardiovascular devices, or skin dressings.</description><subject>Adhesion tests</subject><subject>Anticoagulant</subject><subject>Anticoagulants</subject><subject>Catheters</subject><subject>Crosslinking</subject><subject>Crosslinking polymerization</subject><subject>Formulations</subject><subject>Gelatin</subject><subject>Gelatin hydrogel</subject><subject>Growth factors</subject><subject>Heparin</subject><subject>Hydrogels</subject><subject>Materials science</subject><subject>Organic chemistry</subject><subject>Platelets</subject><subject>Platelets adhesion</subject><subject>Sustained release</subject><subject>Therapeutic agent</subject><subject>Toluidine blue</subject><issn>0167-577X</issn><issn>1873-4979</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kEFLxDAQhYMouK7-Aw8Fz62ZNE3aiyCL7goLXhS8hTSZuq3dZk26wv57U-rZ0zDwvTfzHiG3QDOgIO67bK_HHseMUSgzKjLK5RlZQCnzlFeyOieLiMm0kPLjklyF0FFKeUX5gmxW3oXQt8MX2uQTez22Q7I7We_iEhIdEqO9b9GHpHE-MW4Yvev7CO_woH2EPfaoA16Ti0b3AW_-5pK8Pz-9rTbp9nX9snrcpibP-ZiCpmUjNOOlRWorTqGidS1N_BWhNHWTWygsCA1CsFoWjDXMWGASeVEUgudLcjf7Hrz7PmIYVeeOfognFQMoJJOSTxSfKTPF89iog2_32p8UUDV1pjo1d6amzhQVKnYWZQ-zLGbHn5haBdPiYNC2Hs2orGv_N_gFcI53EA</recordid><startdate>20181001</startdate><enddate>20181001</enddate><creator>Gritsch, Lukas</creator><creator>Motta, Federico L.</creator><creator>Contessi Negrini, Nicola</creator><creator>Yahia, L'Hocine</creator><creator>Farè, Silvia</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><orcidid>https://orcid.org/0000-0003-3719-8869</orcidid><orcidid>https://orcid.org/0000-0002-0303-1131</orcidid></search><sort><creationdate>20181001</creationdate><title>Crosslinked gelatin hydrogels as carriers for controlled heparin release</title><author>Gritsch, Lukas ; Motta, Federico L. ; Contessi Negrini, Nicola ; Yahia, L'Hocine ; Farè, Silvia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c334t-1a08f6a248de0d940190bb7c187e18cbf3d15d16a1662b7522f2cd127e4555643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adhesion tests</topic><topic>Anticoagulant</topic><topic>Anticoagulants</topic><topic>Catheters</topic><topic>Crosslinking</topic><topic>Crosslinking polymerization</topic><topic>Formulations</topic><topic>Gelatin</topic><topic>Gelatin hydrogel</topic><topic>Growth factors</topic><topic>Heparin</topic><topic>Hydrogels</topic><topic>Materials science</topic><topic>Organic chemistry</topic><topic>Platelets</topic><topic>Platelets adhesion</topic><topic>Sustained release</topic><topic>Therapeutic agent</topic><topic>Toluidine blue</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gritsch, Lukas</creatorcontrib><creatorcontrib>Motta, Federico L.</creatorcontrib><creatorcontrib>Contessi Negrini, Nicola</creatorcontrib><creatorcontrib>Yahia, L'Hocine</creatorcontrib><creatorcontrib>Farè, Silvia</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Materials letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gritsch, Lukas</au><au>Motta, Federico L.</au><au>Contessi Negrini, Nicola</au><au>Yahia, L'Hocine</au><au>Farè, Silvia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Crosslinked gelatin hydrogels as carriers for controlled heparin release</atitle><jtitle>Materials letters</jtitle><date>2018-10-01</date><risdate>2018</risdate><volume>228</volume><spage>375</spage><epage>378</epage><pages>375-378</pages><issn>0167-577X</issn><eissn>1873-4979</eissn><abstract>[Display omitted]
•Crosslinked gelatin hydrogel for sustained release of heparin.•The release can be tailored to the needs by varying hydrogel crosslinking degree.•Lower platelets adhesion on heparin-loaded hydrogels.•Possible application as coating in catheters and cardiovascular devices.
The application of heparin as anticoagulant, anti-inflammatory and growth factor regulating agent is currently limited by its narrow therapeutic window. Here, we describe the use of chemically crosslinked gelatin hydrogels as delivery platform to achieve the control of heparin release over time. Different hydrogel formulations and two strategies for heparin loading were tested. The synergic electrostatic interactions between heparin and gelatin hydrogels resulted in a sustained release until 60 h, demonstrated by toluidine blue tests. Platelets adhesion was significantly reduced in heparin-loaded hydrogels, thus proving good heparin bioactivity after processing. Our heparin-loaded hydrogels represent a possible valid option to develop coating for catheters and cardiovascular devices, or skin dressings.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><doi>10.1016/j.matlet.2018.06.047</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0003-3719-8869</orcidid><orcidid>https://orcid.org/0000-0002-0303-1131</orcidid></addata></record> |
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| ispartof | Materials letters, 2018-10, Vol.228, p.375-378 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Adhesion tests Anticoagulant Anticoagulants Catheters Crosslinking Crosslinking polymerization Formulations Gelatin Gelatin hydrogel Growth factors Heparin Hydrogels Materials science Organic chemistry Platelets Platelets adhesion Sustained release Therapeutic agent Toluidine blue |
| title | Crosslinked gelatin hydrogels as carriers for controlled heparin release |
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