Effect of Nelumbo nucifera fruit on scopolamine induced memory deficits and motor coordination
From prehistoric time till today herbal medications are supposed to have neuroprotective effects both by inhibiting acetyl cholinesterase enzyme or antioxidant ability and are also affordable. Thus extensive studies are necessary to investigate the pharmacological effects of herbal plants. The goal...
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| Veröffentlicht in: | Metabolic brain disease 2019-02, Vol.34 (1), p.87-92 |
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| creator | Khan, Rafeeq Alam Rajput, Muhammad Ali Assad, Tahira |
| description | From prehistoric time till today herbal medications are supposed to have neuroprotective effects both by inhibiting acetyl cholinesterase enzyme or antioxidant ability and are also affordable. Thus extensive studies are necessary to investigate the pharmacological effects of herbal plants. The goal of the present study was to ascertain the outcome of
Nelumbo nucifera
fruit (NNF) on scopolamine induced amnestic rats along with motor coordination in mice in order to explore its pharmacological use in disorders like Alzheimer’s disease (AD). The effect of NNF on learning and memory was assessed by Morris water maze test using 35 Wister rats weighing 200–230 g evenly divided in to five groups. While motor coordination was assessed using Rot rod test, 35 male locally bred albino mice weighing 20–25 g were equally divided in to five groups. Group I was kept as control (10 ml/kg gum tragacanth). Group II, III and IV were labeled as treated groups (NNF 50, 100 and 200 mg/kg). Group V served as reference group (piracetam 200 mg/kg). All drugs were given by oral route as a single dose for 15 days in both experiments to rats and mice, however scopolamine (1 mg/kg IP) was used in Morris water maze test 40 min after the administration of drugs to rats for the induction of amnesia. In Morris water maze test,
N. nucifera
fruit caused highly significant and significant decrease in escape latency in the amnestic rats at 200 and 100 mg/kg as compared to control. In Rota rod test,
N. nucifera
fruit did not exhibit any notable changes in the riding time at any dose as compared to control.
N. nucifera
fruit have demonstrated ameliorating effects on memory without affecting muscle coordination. Hence NNF seems to have great potential for therapeutic application in memory disorders, such as AD which may be due to its ability to enhance cholinergic neurotransmission and exerting antioxidant effect and thus encourage more preclinical and clinical trials in this field. |
| doi_str_mv | 10.1007/s11011-018-0324-1 |
| format | Article |
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Nelumbo nucifera
fruit (NNF) on scopolamine induced amnestic rats along with motor coordination in mice in order to explore its pharmacological use in disorders like Alzheimer’s disease (AD). The effect of NNF on learning and memory was assessed by Morris water maze test using 35 Wister rats weighing 200–230 g evenly divided in to five groups. While motor coordination was assessed using Rot rod test, 35 male locally bred albino mice weighing 20–25 g were equally divided in to five groups. Group I was kept as control (10 ml/kg gum tragacanth). Group II, III and IV were labeled as treated groups (NNF 50, 100 and 200 mg/kg). Group V served as reference group (piracetam 200 mg/kg). All drugs were given by oral route as a single dose for 15 days in both experiments to rats and mice, however scopolamine (1 mg/kg IP) was used in Morris water maze test 40 min after the administration of drugs to rats for the induction of amnesia. In Morris water maze test,
N. nucifera
fruit caused highly significant and significant decrease in escape latency in the amnestic rats at 200 and 100 mg/kg as compared to control. In Rota rod test,
N. nucifera
fruit did not exhibit any notable changes in the riding time at any dose as compared to control.
N. nucifera
fruit have demonstrated ameliorating effects on memory without affecting muscle coordination. Hence NNF seems to have great potential for therapeutic application in memory disorders, such as AD which may be due to its ability to enhance cholinergic neurotransmission and exerting antioxidant effect and thus encourage more preclinical and clinical trials in this field.</description><identifier>ISSN: 0885-7490</identifier><identifier>EISSN: 1573-7365</identifier><identifier>DOI: 10.1007/s11011-018-0324-1</identifier><identifier>PMID: 30270417</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Alzheimer's disease ; Amnesia ; Animal memory ; Animals ; Antioxidants ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cholinesterase ; Clinical trials ; Control rods ; Coordination ; Disorders ; Drug dosages ; Drugs ; Fruits ; Latency ; Learning ; Male ; Maze learning ; Maze Learning - drug effects ; Medical research ; Memory ; Memory Disorders - chemically induced ; Memory Disorders - drug therapy ; Metabolic Diseases ; Mice ; Motor ability ; Motor Activity - drug effects ; Motors ; Muscles ; Nelumbo ; Nelumbo nucifera ; Neurology ; Neuroprotection ; Neuroprotective Agents - pharmacology ; Neuroprotective Agents - therapeutic use ; Neurosciences ; Neurotransmission ; Oncology ; Original Article ; Pharmacology ; Piracetam ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Prehistoric era ; Rats ; Rats, Wistar ; Rodents ; Rot ; Rotarod Performance Test ; Scopolamine ; Tragacanth ; Weighing</subject><ispartof>Metabolic brain disease, 2019-02, Vol.34 (1), p.87-92</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>Metabolic Brain Disease is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-ee3f242d5ab80ef61ce473242db949492d754f630cf8f9be008c1572439a1abd3</citedby><cites>FETCH-LOGICAL-c372t-ee3f242d5ab80ef61ce473242db949492d754f630cf8f9be008c1572439a1abd3</cites><orcidid>0000-0002-8051-759X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11011-018-0324-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11011-018-0324-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30270417$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khan, Rafeeq Alam</creatorcontrib><creatorcontrib>Rajput, Muhammad Ali</creatorcontrib><creatorcontrib>Assad, Tahira</creatorcontrib><title>Effect of Nelumbo nucifera fruit on scopolamine induced memory deficits and motor coordination</title><title>Metabolic brain disease</title><addtitle>Metab Brain Dis</addtitle><addtitle>Metab Brain Dis</addtitle><description>From prehistoric time till today herbal medications are supposed to have neuroprotective effects both by inhibiting acetyl cholinesterase enzyme or antioxidant ability and are also affordable. Thus extensive studies are necessary to investigate the pharmacological effects of herbal plants. The goal of the present study was to ascertain the outcome of
Nelumbo nucifera
fruit (NNF) on scopolamine induced amnestic rats along with motor coordination in mice in order to explore its pharmacological use in disorders like Alzheimer’s disease (AD). The effect of NNF on learning and memory was assessed by Morris water maze test using 35 Wister rats weighing 200–230 g evenly divided in to five groups. While motor coordination was assessed using Rot rod test, 35 male locally bred albino mice weighing 20–25 g were equally divided in to five groups. Group I was kept as control (10 ml/kg gum tragacanth). Group II, III and IV were labeled as treated groups (NNF 50, 100 and 200 mg/kg). Group V served as reference group (piracetam 200 mg/kg). All drugs were given by oral route as a single dose for 15 days in both experiments to rats and mice, however scopolamine (1 mg/kg IP) was used in Morris water maze test 40 min after the administration of drugs to rats for the induction of amnesia. In Morris water maze test,
N. nucifera
fruit caused highly significant and significant decrease in escape latency in the amnestic rats at 200 and 100 mg/kg as compared to control. In Rota rod test,
N. nucifera
fruit did not exhibit any notable changes in the riding time at any dose as compared to control.
N. nucifera
fruit have demonstrated ameliorating effects on memory without affecting muscle coordination. Hence NNF seems to have great potential for therapeutic application in memory disorders, such as AD which may be due to its ability to enhance cholinergic neurotransmission and exerting antioxidant effect and thus encourage more preclinical and clinical trials in this field.</description><subject>Alzheimer's disease</subject><subject>Amnesia</subject><subject>Animal memory</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cholinesterase</subject><subject>Clinical trials</subject><subject>Control rods</subject><subject>Coordination</subject><subject>Disorders</subject><subject>Drug dosages</subject><subject>Drugs</subject><subject>Fruits</subject><subject>Latency</subject><subject>Learning</subject><subject>Male</subject><subject>Maze learning</subject><subject>Maze Learning - drug effects</subject><subject>Medical research</subject><subject>Memory</subject><subject>Memory Disorders - chemically induced</subject><subject>Memory Disorders - drug therapy</subject><subject>Metabolic Diseases</subject><subject>Mice</subject><subject>Motor ability</subject><subject>Motor Activity - drug effects</subject><subject>Motors</subject><subject>Muscles</subject><subject>Nelumbo</subject><subject>Nelumbo nucifera</subject><subject>Neurology</subject><subject>Neuroprotection</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Neuroprotective Agents - therapeutic use</subject><subject>Neurosciences</subject><subject>Neurotransmission</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Pharmacology</subject><subject>Piracetam</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Prehistoric era</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Rot</subject><subject>Rotarod Performance Test</subject><subject>Scopolamine</subject><subject>Tragacanth</subject><subject>Weighing</subject><issn>0885-7490</issn><issn>1573-7365</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kE9rHDEMxU1oyG7SfoBeiqHnaSXbs545lpA_hZBekmuMxyMXLzv21p455NvHy27TU9FBID29h36MfUb4hgD6e0EExAawa0AK1eAZW2OrZaPlpv3A1tB1baNVDyt2WcoWAGSL_QVbSRAaFOo1e7nxntzMk-ePtFumIfG4uOApW-7zEuom8uLSPu3sFCLxEMfF0cgnmlJ-5SP54MJcuI11luaUuUspjyHaOaT4kZ17uyv06dSv2PPtzdP1ffPw6-7n9Y-Hxkkt5oZIeqHE2NqhA_IbdKS0PEyGXtUSo26V30hwvvP9QACdq48KJXuLdhjlFft69N3n9GehMpttWnKskUYgKtVj33VVhUeVy6mUTN7sc5hsfjUI5kDUHImaStQciBqsN19Ozssw0fh-8RdhFYijoNRV_E35X_T_Xd8Ah6qBPA</recordid><startdate>20190201</startdate><enddate>20190201</enddate><creator>Khan, Rafeeq Alam</creator><creator>Rajput, Muhammad Ali</creator><creator>Assad, Tahira</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><orcidid>https://orcid.org/0000-0002-8051-759X</orcidid></search><sort><creationdate>20190201</creationdate><title>Effect of Nelumbo nucifera fruit on scopolamine induced memory deficits and motor coordination</title><author>Khan, Rafeeq Alam ; Rajput, Muhammad Ali ; Assad, Tahira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-ee3f242d5ab80ef61ce473242db949492d754f630cf8f9be008c1572439a1abd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Alzheimer's disease</topic><topic>Amnesia</topic><topic>Animal memory</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cholinesterase</topic><topic>Clinical trials</topic><topic>Control rods</topic><topic>Coordination</topic><topic>Disorders</topic><topic>Drug dosages</topic><topic>Drugs</topic><topic>Fruits</topic><topic>Latency</topic><topic>Learning</topic><topic>Male</topic><topic>Maze learning</topic><topic>Maze Learning - drug effects</topic><topic>Medical research</topic><topic>Memory</topic><topic>Memory Disorders - chemically induced</topic><topic>Memory Disorders - drug therapy</topic><topic>Metabolic Diseases</topic><topic>Mice</topic><topic>Motor ability</topic><topic>Motor Activity - drug effects</topic><topic>Motors</topic><topic>Muscles</topic><topic>Nelumbo</topic><topic>Nelumbo nucifera</topic><topic>Neurology</topic><topic>Neuroprotection</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Neuroprotective Agents - therapeutic use</topic><topic>Neurosciences</topic><topic>Neurotransmission</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Pharmacology</topic><topic>Piracetam</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Prehistoric era</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Rot</topic><topic>Rotarod Performance Test</topic><topic>Scopolamine</topic><topic>Tragacanth</topic><topic>Weighing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khan, Rafeeq Alam</creatorcontrib><creatorcontrib>Rajput, Muhammad Ali</creatorcontrib><creatorcontrib>Assad, Tahira</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Metabolic brain disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khan, Rafeeq Alam</au><au>Rajput, Muhammad Ali</au><au>Assad, Tahira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Nelumbo nucifera fruit on scopolamine induced memory deficits and motor coordination</atitle><jtitle>Metabolic brain disease</jtitle><stitle>Metab Brain Dis</stitle><addtitle>Metab Brain Dis</addtitle><date>2019-02-01</date><risdate>2019</risdate><volume>34</volume><issue>1</issue><spage>87</spage><epage>92</epage><pages>87-92</pages><issn>0885-7490</issn><eissn>1573-7365</eissn><abstract>From prehistoric time till today herbal medications are supposed to have neuroprotective effects both by inhibiting acetyl cholinesterase enzyme or antioxidant ability and are also affordable. Thus extensive studies are necessary to investigate the pharmacological effects of herbal plants. The goal of the present study was to ascertain the outcome of
Nelumbo nucifera
fruit (NNF) on scopolamine induced amnestic rats along with motor coordination in mice in order to explore its pharmacological use in disorders like Alzheimer’s disease (AD). The effect of NNF on learning and memory was assessed by Morris water maze test using 35 Wister rats weighing 200–230 g evenly divided in to five groups. While motor coordination was assessed using Rot rod test, 35 male locally bred albino mice weighing 20–25 g were equally divided in to five groups. Group I was kept as control (10 ml/kg gum tragacanth). Group II, III and IV were labeled as treated groups (NNF 50, 100 and 200 mg/kg). Group V served as reference group (piracetam 200 mg/kg). All drugs were given by oral route as a single dose for 15 days in both experiments to rats and mice, however scopolamine (1 mg/kg IP) was used in Morris water maze test 40 min after the administration of drugs to rats for the induction of amnesia. In Morris water maze test,
N. nucifera
fruit caused highly significant and significant decrease in escape latency in the amnestic rats at 200 and 100 mg/kg as compared to control. In Rota rod test,
N. nucifera
fruit did not exhibit any notable changes in the riding time at any dose as compared to control.
N. nucifera
fruit have demonstrated ameliorating effects on memory without affecting muscle coordination. Hence NNF seems to have great potential for therapeutic application in memory disorders, such as AD which may be due to its ability to enhance cholinergic neurotransmission and exerting antioxidant effect and thus encourage more preclinical and clinical trials in this field.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>30270417</pmid><doi>10.1007/s11011-018-0324-1</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-8051-759X</orcidid></addata></record> |
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| subjects | Alzheimer's disease Amnesia Animal memory Animals Antioxidants Biochemistry Biomedical and Life Sciences Biomedicine Cholinesterase Clinical trials Control rods Coordination Disorders Drug dosages Drugs Fruits Latency Learning Male Maze learning Maze Learning - drug effects Medical research Memory Memory Disorders - chemically induced Memory Disorders - drug therapy Metabolic Diseases Mice Motor ability Motor Activity - drug effects Motors Muscles Nelumbo Nelumbo nucifera Neurology Neuroprotection Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Neurosciences Neurotransmission Oncology Original Article Pharmacology Piracetam Plant Extracts - pharmacology Plant Extracts - therapeutic use Prehistoric era Rats Rats, Wistar Rodents Rot Rotarod Performance Test Scopolamine Tragacanth Weighing |
| title | Effect of Nelumbo nucifera fruit on scopolamine induced memory deficits and motor coordination |
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