Effect of Diafenthiuron exposure under short and long term experimental conditions on hematology, serum biochemical profile and elemental composition of a non-target organism, Labeo rohita
[Display omitted] •Blood cell count was drastically affected in Labeo rohita exposed to Diafenthiuron.•Serum parameters varied significantly in L. rohita exposed to Diafenthiuron.•Elemental concentration in muscles of L. rohita varied significantly. Diafenthiuron is a thiourea compound that has a no...
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| Veröffentlicht in: | Environmental toxicology and pharmacology 2018-09, Vol.62, p.40-45 |
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| creator | Riaz-ul-Haq, Muhammad Javeed, Rabia Iram, Saman Rasheed, Muhammad Arslan Amjad, Muhammad Iqbal, Furhan |
| description | [Display omitted]
•Blood cell count was drastically affected in Labeo rohita exposed to Diafenthiuron.•Serum parameters varied significantly in L. rohita exposed to Diafenthiuron.•Elemental concentration in muscles of L. rohita varied significantly.
Diafenthiuron is a thiourea compound that has a novel mode of action as it inhibits mitochondrial functioning in insect pests. It has been reported in local newspapers that this pesticide is entering in our fresh water bodies on regular basis and it is a potential threat for aquatic life. The present study was designed to determine effect of Diafenthiuron, a commonly used pesticide in Pakistan, on the hematology, serum biochemical profile and elemental composition of a non-target organism, Labeo rohita (L. rohita). A sub-lethal dose (0.0075 mg L-1) of Diafenthiuron was applied under short (2, 4 and 8 days) and long term (16, 32 and 64 days) experimental conditions. Our results indicated that the pesticide exposed fish had significantly higher white blood count, lymphocyte, red blood cell count, hemoglobin, hematocrit, mean corpuscular volume, red cell distribution width than the control group. However, platelets count, plateletcrit and platelet distribution width were significantly reduced in Diafenthiuron treatments than their respective control groups. Concentration of total serum proteins, albumin, globulin, cholesterol, triglycerides and AST were disturbed in pesticide exposed treatments compared to control groups. Comparison of elemental concentrations revealed that calcium, potassium and cadmium concentration varied significantly when compared between Diafenthiuron treated and untreated L. rohita.
In conclusion, we are reporting that Diafenthiuron can adversely affect the hematological, serum and elemental concentrations of a non-target organism like L. rohita and may therefore pose a threat to the food web. |
| doi_str_mv | 10.1016/j.etap.2018.06.006 |
| format | Article |
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•Blood cell count was drastically affected in Labeo rohita exposed to Diafenthiuron.•Serum parameters varied significantly in L. rohita exposed to Diafenthiuron.•Elemental concentration in muscles of L. rohita varied significantly.
Diafenthiuron is a thiourea compound that has a novel mode of action as it inhibits mitochondrial functioning in insect pests. It has been reported in local newspapers that this pesticide is entering in our fresh water bodies on regular basis and it is a potential threat for aquatic life. The present study was designed to determine effect of Diafenthiuron, a commonly used pesticide in Pakistan, on the hematology, serum biochemical profile and elemental composition of a non-target organism, Labeo rohita (L. rohita). A sub-lethal dose (0.0075 mg L-1) of Diafenthiuron was applied under short (2, 4 and 8 days) and long term (16, 32 and 64 days) experimental conditions. Our results indicated that the pesticide exposed fish had significantly higher white blood count, lymphocyte, red blood cell count, hemoglobin, hematocrit, mean corpuscular volume, red cell distribution width than the control group. However, platelets count, plateletcrit and platelet distribution width were significantly reduced in Diafenthiuron treatments than their respective control groups. Concentration of total serum proteins, albumin, globulin, cholesterol, triglycerides and AST were disturbed in pesticide exposed treatments compared to control groups. Comparison of elemental concentrations revealed that calcium, potassium and cadmium concentration varied significantly when compared between Diafenthiuron treated and untreated L. rohita.
In conclusion, we are reporting that Diafenthiuron can adversely affect the hematological, serum and elemental concentrations of a non-target organism like L. rohita and may therefore pose a threat to the food web.</description><identifier>ISSN: 1382-6689</identifier><identifier>EISSN: 1872-7077</identifier><identifier>DOI: 10.1016/j.etap.2018.06.006</identifier><identifier>PMID: 29957367</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Aquatic organisms ; Blood ; Cadmium ; Calcium ; Chemical composition ; Cholesterol ; Diafenthiuron ; Elemental composition ; Environmental science ; Erythrocytes ; Exposure ; Food chains ; Food webs ; Fresh water ; Freshwater environments ; Globulins ; Hematocrit ; Hematological profile ; Hematology ; Hemoglobin ; Insects ; Labeo rohita ; Lethal dose ; Mitochondria ; Mode of action ; Pesticides ; Pests ; Platelets ; Potassium ; Proteins ; serum biochemistry ; Serum proteins ; Thiourea ; Toxicity ; Triglycerides</subject><ispartof>Environmental toxicology and pharmacology, 2018-09, Vol.62, p.40-45</ispartof><rights>2018 Elsevier B.V.</rights><rights>Copyright © 2018 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier Science Ltd. Sep 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-2e6084af8e30cc3996c71f4a1754d929308f953bb26a482c729707badf3d66e13</citedby><cites>FETCH-LOGICAL-c384t-2e6084af8e30cc3996c71f4a1754d929308f953bb26a482c729707badf3d66e13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1382668918301492$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29957367$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Riaz-ul-Haq, Muhammad</creatorcontrib><creatorcontrib>Javeed, Rabia</creatorcontrib><creatorcontrib>Iram, Saman</creatorcontrib><creatorcontrib>Rasheed, Muhammad Arslan</creatorcontrib><creatorcontrib>Amjad, Muhammad</creatorcontrib><creatorcontrib>Iqbal, Furhan</creatorcontrib><title>Effect of Diafenthiuron exposure under short and long term experimental conditions on hematology, serum biochemical profile and elemental composition of a non-target organism, Labeo rohita</title><title>Environmental toxicology and pharmacology</title><addtitle>Environ Toxicol Pharmacol</addtitle><description>[Display omitted]
•Blood cell count was drastically affected in Labeo rohita exposed to Diafenthiuron.•Serum parameters varied significantly in L. rohita exposed to Diafenthiuron.•Elemental concentration in muscles of L. rohita varied significantly.
Diafenthiuron is a thiourea compound that has a novel mode of action as it inhibits mitochondrial functioning in insect pests. It has been reported in local newspapers that this pesticide is entering in our fresh water bodies on regular basis and it is a potential threat for aquatic life. The present study was designed to determine effect of Diafenthiuron, a commonly used pesticide in Pakistan, on the hematology, serum biochemical profile and elemental composition of a non-target organism, Labeo rohita (L. rohita). A sub-lethal dose (0.0075 mg L-1) of Diafenthiuron was applied under short (2, 4 and 8 days) and long term (16, 32 and 64 days) experimental conditions. Our results indicated that the pesticide exposed fish had significantly higher white blood count, lymphocyte, red blood cell count, hemoglobin, hematocrit, mean corpuscular volume, red cell distribution width than the control group. However, platelets count, plateletcrit and platelet distribution width were significantly reduced in Diafenthiuron treatments than their respective control groups. Concentration of total serum proteins, albumin, globulin, cholesterol, triglycerides and AST were disturbed in pesticide exposed treatments compared to control groups. Comparison of elemental concentrations revealed that calcium, potassium and cadmium concentration varied significantly when compared between Diafenthiuron treated and untreated L. rohita.
In conclusion, we are reporting that Diafenthiuron can adversely affect the hematological, serum and elemental concentrations of a non-target organism like L. rohita and may therefore pose a threat to the food web.</description><subject>Aquatic organisms</subject><subject>Blood</subject><subject>Cadmium</subject><subject>Calcium</subject><subject>Chemical composition</subject><subject>Cholesterol</subject><subject>Diafenthiuron</subject><subject>Elemental composition</subject><subject>Environmental science</subject><subject>Erythrocytes</subject><subject>Exposure</subject><subject>Food chains</subject><subject>Food webs</subject><subject>Fresh water</subject><subject>Freshwater environments</subject><subject>Globulins</subject><subject>Hematocrit</subject><subject>Hematological profile</subject><subject>Hematology</subject><subject>Hemoglobin</subject><subject>Insects</subject><subject>Labeo rohita</subject><subject>Lethal dose</subject><subject>Mitochondria</subject><subject>Mode of action</subject><subject>Pesticides</subject><subject>Pests</subject><subject>Platelets</subject><subject>Potassium</subject><subject>Proteins</subject><subject>serum biochemistry</subject><subject>Serum proteins</subject><subject>Thiourea</subject><subject>Toxicity</subject><subject>Triglycerides</subject><issn>1382-6689</issn><issn>1872-7077</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u1DAUhS0EoqXwAiyQJbZN8E_iOBIbVMqPNBIbWFuOfT3jUWIPtoPou_FwOJ3SJStb1nfOPb4HodeUtJRQ8e7YQtGnlhEqWyJaQsQTdEnlwJqBDMPTeueSNULI8QK9yPlICO05l8_RBRvHfuBiuER_bp0DU3B0-KPXDkI5-DXFgOH3KeY1AV6DhYTzIaaCdbB4jmGPC6RlQyD5pWr0jE0M1hcfQ8ZVfYBFlzjH_d01zpDWBU8-mvrqTWVPKTo_w70dzPDosNSR9x5bHI1DDE3RaQ81Xtrr4PNyjXd6gohTPPiiX6JnTs8ZXj2cV-jHp9vvN1-a3bfPX28-7BrDZVcaBoLITjsJnBjDx1GYgbpO06Hv7MhGTqQbez5NTOhOMjOwsS5w0tZxKwRQfoXenn1r8J8r5KKOcU2hjlSM0o7RvhOiUuxMmRRzTuDUqW5HpztFidoKU0e1Faa2whQRqhZWRW8erNdpAfso-ddQBd6fAagf_OUhqWw8BAPWp1qcstH_z_8vRU2rfw</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Riaz-ul-Haq, Muhammad</creator><creator>Javeed, Rabia</creator><creator>Iram, Saman</creator><creator>Rasheed, Muhammad Arslan</creator><creator>Amjad, Muhammad</creator><creator>Iqbal, Furhan</creator><general>Elsevier B.V</general><general>Elsevier Science Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7ST</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>SOI</scope></search><sort><creationdate>20180901</creationdate><title>Effect of Diafenthiuron exposure under short and long term experimental conditions on hematology, serum biochemical profile and elemental composition of a non-target organism, Labeo rohita</title><author>Riaz-ul-Haq, Muhammad ; Javeed, Rabia ; Iram, Saman ; Rasheed, Muhammad Arslan ; Amjad, Muhammad ; Iqbal, Furhan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-2e6084af8e30cc3996c71f4a1754d929308f953bb26a482c729707badf3d66e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aquatic organisms</topic><topic>Blood</topic><topic>Cadmium</topic><topic>Calcium</topic><topic>Chemical composition</topic><topic>Cholesterol</topic><topic>Diafenthiuron</topic><topic>Elemental composition</topic><topic>Environmental science</topic><topic>Erythrocytes</topic><topic>Exposure</topic><topic>Food chains</topic><topic>Food webs</topic><topic>Fresh water</topic><topic>Freshwater environments</topic><topic>Globulins</topic><topic>Hematocrit</topic><topic>Hematological profile</topic><topic>Hematology</topic><topic>Hemoglobin</topic><topic>Insects</topic><topic>Labeo rohita</topic><topic>Lethal dose</topic><topic>Mitochondria</topic><topic>Mode of action</topic><topic>Pesticides</topic><topic>Pests</topic><topic>Platelets</topic><topic>Potassium</topic><topic>Proteins</topic><topic>serum biochemistry</topic><topic>Serum proteins</topic><topic>Thiourea</topic><topic>Toxicity</topic><topic>Triglycerides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Riaz-ul-Haq, Muhammad</creatorcontrib><creatorcontrib>Javeed, Rabia</creatorcontrib><creatorcontrib>Iram, Saman</creatorcontrib><creatorcontrib>Rasheed, Muhammad Arslan</creatorcontrib><creatorcontrib>Amjad, Muhammad</creatorcontrib><creatorcontrib>Iqbal, Furhan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Environment Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><jtitle>Environmental toxicology and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Riaz-ul-Haq, Muhammad</au><au>Javeed, Rabia</au><au>Iram, Saman</au><au>Rasheed, Muhammad Arslan</au><au>Amjad, Muhammad</au><au>Iqbal, Furhan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Diafenthiuron exposure under short and long term experimental conditions on hematology, serum biochemical profile and elemental composition of a non-target organism, Labeo rohita</atitle><jtitle>Environmental toxicology and pharmacology</jtitle><addtitle>Environ Toxicol Pharmacol</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>62</volume><spage>40</spage><epage>45</epage><pages>40-45</pages><issn>1382-6689</issn><eissn>1872-7077</eissn><abstract>[Display omitted]
•Blood cell count was drastically affected in Labeo rohita exposed to Diafenthiuron.•Serum parameters varied significantly in L. rohita exposed to Diafenthiuron.•Elemental concentration in muscles of L. rohita varied significantly.
Diafenthiuron is a thiourea compound that has a novel mode of action as it inhibits mitochondrial functioning in insect pests. It has been reported in local newspapers that this pesticide is entering in our fresh water bodies on regular basis and it is a potential threat for aquatic life. The present study was designed to determine effect of Diafenthiuron, a commonly used pesticide in Pakistan, on the hematology, serum biochemical profile and elemental composition of a non-target organism, Labeo rohita (L. rohita). A sub-lethal dose (0.0075 mg L-1) of Diafenthiuron was applied under short (2, 4 and 8 days) and long term (16, 32 and 64 days) experimental conditions. Our results indicated that the pesticide exposed fish had significantly higher white blood count, lymphocyte, red blood cell count, hemoglobin, hematocrit, mean corpuscular volume, red cell distribution width than the control group. However, platelets count, plateletcrit and platelet distribution width were significantly reduced in Diafenthiuron treatments than their respective control groups. Concentration of total serum proteins, albumin, globulin, cholesterol, triglycerides and AST were disturbed in pesticide exposed treatments compared to control groups. Comparison of elemental concentrations revealed that calcium, potassium and cadmium concentration varied significantly when compared between Diafenthiuron treated and untreated L. rohita.
In conclusion, we are reporting that Diafenthiuron can adversely affect the hematological, serum and elemental concentrations of a non-target organism like L. rohita and may therefore pose a threat to the food web.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>29957367</pmid><doi>10.1016/j.etap.2018.06.006</doi><tpages>6</tpages></addata></record> |
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| ispartof | Environmental toxicology and pharmacology, 2018-09, Vol.62, p.40-45 |
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| source | Elsevier ScienceDirect Journals |
| subjects | Aquatic organisms Blood Cadmium Calcium Chemical composition Cholesterol Diafenthiuron Elemental composition Environmental science Erythrocytes Exposure Food chains Food webs Fresh water Freshwater environments Globulins Hematocrit Hematological profile Hematology Hemoglobin Insects Labeo rohita Lethal dose Mitochondria Mode of action Pesticides Pests Platelets Potassium Proteins serum biochemistry Serum proteins Thiourea Toxicity Triglycerides |
| title | Effect of Diafenthiuron exposure under short and long term experimental conditions on hematology, serum biochemical profile and elemental composition of a non-target organism, Labeo rohita |
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