How do oxyphytosterols affect human health?
Oxyphytosterols are similar to oxycholesterols in structure, and they exhibit pro-atherogenic properties. Recently, more interests were focused on the metabolism of oxyphytosterols for their increasing intake from phytosterol-enriched food. In this review, we discussed the origin, absorption, distri...
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| Veröffentlicht in: | Trends in food science & technology 2018-09, Vol.79, p.148-159 |
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| description | Oxyphytosterols are similar to oxycholesterols in structure, and they exhibit pro-atherogenic properties. Recently, more interests were focused on the metabolism of oxyphytosterols for their increasing intake from phytosterol-enriched food. In this review, we discussed the origin, absorption, distribution, and transport of oxyphytosterols in vivo and their biological effects in humans. The two dominant oxyphytosterols in human plasma are 7-keto-sitosterol and 7-keto-campesterol, but their origins are unclear. It is suggested that oxysitosterols are formed to eliminate sitosterol from tissue to the blood stream. Aside from the pro-atherogenic, oxyphytosterols also exhibit pro-inflammatory properties and antiviral activity against equine herpesvirus 1. Further research is needed to investigate the physiological and pathological role of oxyphytosterols in humans.
•We discuss the mechanism of absorption, distribution, and transport of oxyphytosterols in vivo and their biological effects in humans.•The two dominant oxyphytosterols in human plasma are 7-keto-sitosterol and 7-keto-campesterol.•The origin of oxyphytosterols in tissues is unclear.•It is suggested that oxysitotsterols are formed to eliminate sitosterol from tissue to the blood stream.•Aside from the pro-atherogenic, oxyphytosterols also exhibit pro-inflammatory properties and antiviral activity against equine herpesvirus 1.•Further research is needed to investigate the physiological and pathological role of oxyphytosterols in humans. |
| doi_str_mv | 10.1016/j.tifs.2018.07.002 |
| format | Article |
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•We discuss the mechanism of absorption, distribution, and transport of oxyphytosterols in vivo and their biological effects in humans.•The two dominant oxyphytosterols in human plasma are 7-keto-sitosterol and 7-keto-campesterol.•The origin of oxyphytosterols in tissues is unclear.•It is suggested that oxysitotsterols are formed to eliminate sitosterol from tissue to the blood stream.•Aside from the pro-atherogenic, oxyphytosterols also exhibit pro-inflammatory properties and antiviral activity against equine herpesvirus 1.•Further research is needed to investigate the physiological and pathological role of oxyphytosterols in humans.</description><identifier>ISSN: 0924-2244</identifier><identifier>EISSN: 1879-3053</identifier><identifier>DOI: 10.1016/j.tifs.2018.07.002</identifier><language>eng</language><publisher>Cambridge: Elsevier Ltd</publisher><subject>Absorption ; Antiviral activity ; Antiviral drugs ; Biological effects ; Blood plasma ; Cardiovascular disease ; Distribution ; Enriched foods ; Food intake ; Functional foods & nutraceuticals ; Herpes viruses ; Inflammation ; Metabolism ; Neurodegeneration ; Oxyphytosterols ; Transport</subject><ispartof>Trends in food science & technology, 2018-09, Vol.79, p.148-159</ispartof><rights>2018 Elsevier Ltd</rights><rights>Copyright Elsevier BV Sep 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c328t-8d26f7c3ecd6f2ce02de61efd83e1d71b29b0770bb9d3e984cd12b0ced656483</citedby><cites>FETCH-LOGICAL-c328t-8d26f7c3ecd6f2ce02de61efd83e1d71b29b0770bb9d3e984cd12b0ced656483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.tifs.2018.07.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids></links><search><creatorcontrib>Wang, Mengmeng</creatorcontrib><creatorcontrib>Lu, Baiyi</creatorcontrib><title>How do oxyphytosterols affect human health?</title><title>Trends in food science & technology</title><description>Oxyphytosterols are similar to oxycholesterols in structure, and they exhibit pro-atherogenic properties. Recently, more interests were focused on the metabolism of oxyphytosterols for their increasing intake from phytosterol-enriched food. In this review, we discussed the origin, absorption, distribution, and transport of oxyphytosterols in vivo and their biological effects in humans. The two dominant oxyphytosterols in human plasma are 7-keto-sitosterol and 7-keto-campesterol, but their origins are unclear. It is suggested that oxysitosterols are formed to eliminate sitosterol from tissue to the blood stream. Aside from the pro-atherogenic, oxyphytosterols also exhibit pro-inflammatory properties and antiviral activity against equine herpesvirus 1. Further research is needed to investigate the physiological and pathological role of oxyphytosterols in humans.
•We discuss the mechanism of absorption, distribution, and transport of oxyphytosterols in vivo and their biological effects in humans.•The two dominant oxyphytosterols in human plasma are 7-keto-sitosterol and 7-keto-campesterol.•The origin of oxyphytosterols in tissues is unclear.•It is suggested that oxysitotsterols are formed to eliminate sitosterol from tissue to the blood stream.•Aside from the pro-atherogenic, oxyphytosterols also exhibit pro-inflammatory properties and antiviral activity against equine herpesvirus 1.•Further research is needed to investigate the physiological and pathological role of oxyphytosterols in humans.</description><subject>Absorption</subject><subject>Antiviral activity</subject><subject>Antiviral drugs</subject><subject>Biological effects</subject><subject>Blood plasma</subject><subject>Cardiovascular disease</subject><subject>Distribution</subject><subject>Enriched foods</subject><subject>Food intake</subject><subject>Functional foods & nutraceuticals</subject><subject>Herpes viruses</subject><subject>Inflammation</subject><subject>Metabolism</subject><subject>Neurodegeneration</subject><subject>Oxyphytosterols</subject><subject>Transport</subject><issn>0924-2244</issn><issn>1879-3053</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kNFLwzAQxoMoOKf_gE8FH6X1krZJCoLIUCcMfNl7aJMLbdmWmWTq_nsz6rMPx8Hxfffd_Qi5pVBQoPxhLOJgQ8GAygJEAcDOyIxK0eQl1OU5mUHDqpyxqrokVyGMAGlc1zNyv3TfmXGZ-znu-2N0IaJ3m5C11qKOWX_Ytrusx3YT-6drcmHbTcCbvz4n69eX9WKZrz7e3hfPq1yXTMZcGsat0CVqwy3TCMwgp2iNLJEaQTvWdCAEdF1jSmxkpQ1lHWg0vOaVLOfkblq79-7zgCGq0R38LiUqRmmVitd1UrFJpb0LwaNVez9sW39UFNSJiRrViYk6MVEgVGKSTI-TCdP5XwN6FfSAuxQ9-PSuMm74z_4LJVtqHw</recordid><startdate>201809</startdate><enddate>201809</enddate><creator>Wang, Mengmeng</creator><creator>Lu, Baiyi</creator><general>Elsevier Ltd</general><general>Elsevier BV</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QR</scope><scope>7ST</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>P64</scope><scope>SOI</scope></search><sort><creationdate>201809</creationdate><title>How do oxyphytosterols affect human health?</title><author>Wang, Mengmeng ; Lu, Baiyi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c328t-8d26f7c3ecd6f2ce02de61efd83e1d71b29b0770bb9d3e984cd12b0ced656483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Absorption</topic><topic>Antiviral activity</topic><topic>Antiviral drugs</topic><topic>Biological effects</topic><topic>Blood plasma</topic><topic>Cardiovascular disease</topic><topic>Distribution</topic><topic>Enriched foods</topic><topic>Food intake</topic><topic>Functional foods & nutraceuticals</topic><topic>Herpes viruses</topic><topic>Inflammation</topic><topic>Metabolism</topic><topic>Neurodegeneration</topic><topic>Oxyphytosterols</topic><topic>Transport</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Mengmeng</creatorcontrib><creatorcontrib>Lu, Baiyi</creatorcontrib><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><jtitle>Trends in food science & technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Mengmeng</au><au>Lu, Baiyi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>How do oxyphytosterols affect human health?</atitle><jtitle>Trends in food science & technology</jtitle><date>2018-09</date><risdate>2018</risdate><volume>79</volume><spage>148</spage><epage>159</epage><pages>148-159</pages><issn>0924-2244</issn><eissn>1879-3053</eissn><abstract>Oxyphytosterols are similar to oxycholesterols in structure, and they exhibit pro-atherogenic properties. Recently, more interests were focused on the metabolism of oxyphytosterols for their increasing intake from phytosterol-enriched food. In this review, we discussed the origin, absorption, distribution, and transport of oxyphytosterols in vivo and their biological effects in humans. The two dominant oxyphytosterols in human plasma are 7-keto-sitosterol and 7-keto-campesterol, but their origins are unclear. It is suggested that oxysitosterols are formed to eliminate sitosterol from tissue to the blood stream. Aside from the pro-atherogenic, oxyphytosterols also exhibit pro-inflammatory properties and antiviral activity against equine herpesvirus 1. Further research is needed to investigate the physiological and pathological role of oxyphytosterols in humans.
•We discuss the mechanism of absorption, distribution, and transport of oxyphytosterols in vivo and their biological effects in humans.•The two dominant oxyphytosterols in human plasma are 7-keto-sitosterol and 7-keto-campesterol.•The origin of oxyphytosterols in tissues is unclear.•It is suggested that oxysitotsterols are formed to eliminate sitosterol from tissue to the blood stream.•Aside from the pro-atherogenic, oxyphytosterols also exhibit pro-inflammatory properties and antiviral activity against equine herpesvirus 1.•Further research is needed to investigate the physiological and pathological role of oxyphytosterols in humans.</abstract><cop>Cambridge</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.tifs.2018.07.002</doi><tpages>12</tpages></addata></record> |
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| subjects | Absorption Antiviral activity Antiviral drugs Biological effects Blood plasma Cardiovascular disease Distribution Enriched foods Food intake Functional foods & nutraceuticals Herpes viruses Inflammation Metabolism Neurodegeneration Oxyphytosterols Transport |
| title | How do oxyphytosterols affect human health? |
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