Molecular Understanding of Hyperglycemia's Adverse Effects for Diabetic Complications

Diabetic complications are the major cause of morbidity and mortality in persons with diabetes. Chronic hyperglycemia is a major initiator of diabetic microvascular complications (eg, retinopathy, neuropathy, nephropathy). Glucose processing uses a variety of diverse metabolic pathways; hence, chron...

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Veröffentlicht in:	JAMA : the journal of the American Medical Association 2002-11, Vol.288 (20), p.2579-2588
Hauptverfasser:	Sheetz, Matthew J, King, George L
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde Reductase - metabolism Blood vessels Diabetes Diabetic Angiopathies - etiology Diabetic Angiopathies - prevention & control Diabetic Nephropathies - etiology Diabetic Nephropathies - prevention & control Diabetic Neuropathies - etiology Diabetic Neuropathies - prevention & control Glucose Glycation End Products, Advanced - metabolism Glycolysis Glycosylation Humans Hyperglycemia - physiopathology Hyperglycemia - prevention & control Metabolism Neurons Oxidative Phosphorylation Protein Kinase C - metabolism Reactive Oxygen Species Signal Transduction
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