HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis

Huntington disease (HD) is caused by polyglutamine [poly(Q)] expansion in the protein huntingtin (htt). Although the exact mechanism of disease progression remains to be elucidated, altered interactions of mutant htt with its protein partners could contribute to the disease. Using the yeast two-hybr...

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Veröffentlicht in:	Human molecular genetics 2002-11, Vol.11 (23), p.2815-2828
Hauptverfasser:	Singaraja, Roshni R., Hadano, Shinji, Metzler, Martina, Givan, Scott, Wellington, Cheryl L., Warby, Simon, Yanai, Anat, Gutekunst, Claire-Anne, Leavitt, Blair R., Yi, Hong, Fichter, Keith, Gan, Lu, McCutcheon, Krista, Chopra, Vikramjit, Michel, Jennifer, Hersch, Steven M., Ikeda, Joh-E, Hayden, Michael R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferases - genetics Acyltransferases - metabolism Adaptor Proteins, Signal Transducing Animals Ankyrins - chemistry Ankyrins - metabolism Biological and medical sciences Blotting, Northern Brain - metabolism Carrier Proteins - genetics Carrier Proteins - metabolism Cells, Cultured Chromosome Mapping Chromosomes, Human, Pair 12 - genetics Cloning, Molecular Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Endocytosis - physiology Female Humans Huntingtin Protein Huntington Disease - metabolism Immunoenzyme Techniques Medical sciences Mice Mutation Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurology Neurons - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Peptides - genetics Peptides - metabolism Protein Transport Rabbits Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Trinucleotide Repeat Expansion Two-Hybrid System Techniques
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