Independent effects of APOE on cholesterol metabolism and brain A² levels in an Alzheimer disease mouse model

The APOE [varepsilon]4 allele is the most significant genetic risk factor associated with Alzheimer's disease to date. Epidemiological studies have demonstrated that inheritance of one or more [varepsilon]4 alleles affects both the age of onset and the severity of pathology development. Dosage...

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Veröffentlicht in:	Human molecular genetics 2004-09, Vol.13 (17), p.1959
Hauptverfasser:	Mann, Karen M, Thorngate, Fayanne E, Katoh-Fukui, Yuko, Hamanaka, Hiroki, Williams, David L, Fujita, Shinobu, Lamb, Bruce T
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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