Targeted Disruption of the Lysosomal  -Mannosidase Gene Results in Mice Resembling a Mild form of Human  -Mannosidosis

[alpha]-Mannosidosis is a lysosomal storage disease with autosomal recessive inheritance caused by a deficiency of the lysosomal [alpha]-mannosidase, which is involved in the degradation of asparagine-linked carbohydrate cores of glycoproteins. An [alpha]-mannosidosis mouse model was generated by ta...

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Veröffentlicht in:	Human molecular genetics 1999-08, Vol.8 (8), p.1365-1372
Hauptverfasser:	Stinchi, S., Lullmann-Rauch, R., Hartmann, D., Coenen, R., Beccari, T., Orlacchio, A., von Figura, K., Saftig, P.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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