Investigation of Toxic Effect and Penetration into Cells of Monodisperse Spherical Composite Particles Based on Mesoporous Silica
Сomposite particles based on monodisperse spherical mesoporous silica particles (MSMSPs) are synthesized by noncovalent binding of organic active components (propidium iodide fluorescent dye and Radakchlorin photosensitizer) from aqueous solutions. Hybrid particles with a core–shell structure are sy...
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| Veröffentlicht in: | Technical physics 2018-09, Vol.63 (9), p.1316-1322 |
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| container_title | Technical physics |
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| creator | Shmakov, S. V. Klimenko, V. V. Konyakhin, S. V. Eurov, D. A. Kurdyukov, D. A. Golubev, V. G. |
| description | Сomposite particles based on monodisperse spherical mesoporous silica particles (MSMSPs) are synthesized by noncovalent binding of organic active components (propidium iodide fluorescent dye and Radakchlorin photosensitizer) from aqueous solutions. Hybrid particles with a core–shell structure are synthesized, which are MSMSPs filled with Fe
3
O
4
and coated with mesoporous silica, the internal surface of which is modified by Fluorescein isothiocyanate (FITC) fluorescence dye by means of chemisorption. The toxicity and penetration of the obtained particles into the cells of the HeLa and K-562 cell lines were studied. The effective photodynamic action of MSMSPs containing Radachlorin in mesopores is demonstrated, which indicates the promise of using the synthesized composite particles for medical purposes. |
| doi_str_mv | 10.1134/S1063784218090190 |
| format | Article |
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3
O
4
and coated with mesoporous silica, the internal surface of which is modified by Fluorescein isothiocyanate (FITC) fluorescence dye by means of chemisorption. The toxicity and penetration of the obtained particles into the cells of the HeLa and K-562 cell lines were studied. The effective photodynamic action of MSMSPs containing Radachlorin in mesopores is demonstrated, which indicates the promise of using the synthesized composite particles for medical purposes.</description><identifier>ISSN: 1063-7842</identifier><identifier>EISSN: 1090-6525</identifier><identifier>DOI: 10.1134/S1063784218090190</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Chemisorption ; Classical and Continuum Physics ; Core-shell structure ; Development of Process Technologies ; Diagnostic Methods ; Dye penetrants ; Fluorescein ; Fluorescence ; Fluorescent dyes ; Functional Materials and Structures ; Investigations ; Iron oxides ; Organic chemistry ; Particulate composites ; Penetration ; Physics ; Physics and Astronomy ; Porous materials ; Silica ; Silicon dioxide ; Synthesis ; Toxicity</subject><ispartof>Technical physics, 2018-09, Vol.63 (9), p.1316-1322</ispartof><rights>Pleiades Publishing, Ltd. 2018</rights><rights>COPYRIGHT 2018 Springer</rights><rights>Copyright Springer Science & Business Media 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c355t-69dabbb2320d62f6dbee9c57ff2fac45931359ff5f066e8b1188f97d97b968f03</citedby><cites>FETCH-LOGICAL-c355t-69dabbb2320d62f6dbee9c57ff2fac45931359ff5f066e8b1188f97d97b968f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S1063784218090190$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S1063784218090190$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Shmakov, S. V.</creatorcontrib><creatorcontrib>Klimenko, V. V.</creatorcontrib><creatorcontrib>Konyakhin, S. V.</creatorcontrib><creatorcontrib>Eurov, D. A.</creatorcontrib><creatorcontrib>Kurdyukov, D. A.</creatorcontrib><creatorcontrib>Golubev, V. G.</creatorcontrib><title>Investigation of Toxic Effect and Penetration into Cells of Monodisperse Spherical Composite Particles Based on Mesoporous Silica</title><title>Technical physics</title><addtitle>Tech. Phys</addtitle><description>Сomposite particles based on monodisperse spherical mesoporous silica particles (MSMSPs) are synthesized by noncovalent binding of organic active components (propidium iodide fluorescent dye and Radakchlorin photosensitizer) from aqueous solutions. Hybrid particles with a core–shell structure are synthesized, which are MSMSPs filled with Fe
3
O
4
and coated with mesoporous silica, the internal surface of which is modified by Fluorescein isothiocyanate (FITC) fluorescence dye by means of chemisorption. The toxicity and penetration of the obtained particles into the cells of the HeLa and K-562 cell lines were studied. The effective photodynamic action of MSMSPs containing Radachlorin in mesopores is demonstrated, which indicates the promise of using the synthesized composite particles for medical purposes.</description><subject>Chemisorption</subject><subject>Classical and Continuum Physics</subject><subject>Core-shell structure</subject><subject>Development of Process Technologies</subject><subject>Diagnostic Methods</subject><subject>Dye penetrants</subject><subject>Fluorescein</subject><subject>Fluorescence</subject><subject>Fluorescent dyes</subject><subject>Functional Materials and Structures</subject><subject>Investigations</subject><subject>Iron oxides</subject><subject>Organic chemistry</subject><subject>Particulate composites</subject><subject>Penetration</subject><subject>Physics</subject><subject>Physics and Astronomy</subject><subject>Porous materials</subject><subject>Silica</subject><subject>Silicon dioxide</subject><subject>Synthesis</subject><subject>Toxicity</subject><issn>1063-7842</issn><issn>1090-6525</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kUtLxDAUhYMoqKM_wF3AdTWPJm2WOvgYUBRG1yVNb8ZIJ6lJR3TpPzdDBRciWeSSe75zc7gInVByRikvz5eUSF7VJaM1UYQqsoMOaK4KKZjY3daSF9v-PjpM6ZUQSmshD9DXwr9DGt1Kjy54HCx-Ch_O4CtrwYxY-w4_gocxTn3nx4Dn0PdpK70PPnQuDRAT4OXwAtEZ3eN5WA8huRHwo46jMz0kfKkTdDg73EMKQ4hhk_DS9Vl_hPas7hMc_9wz9Hx99TS_Le4ebhbzi7vCcCHGQqpOt23LOCOdZFZ2LYAyorKWWW1KoTjlQlkrLJES6jbnq62qOlW1StaW8Bk6nXyHGN42OXPzGjbR55ENo5SxktfZZIbOJtVK99A4b0OObvLpYO1M8GBdfr8QQlQlpyXLAJ0AE0NKEWwzRLfW8bOhpNmupvmzmsywiUlZ61cQf7_yP_QNuVSRnQ</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Shmakov, S. 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V.</creatorcontrib><creatorcontrib>Klimenko, V. V.</creatorcontrib><creatorcontrib>Konyakhin, S. V.</creatorcontrib><creatorcontrib>Eurov, D. A.</creatorcontrib><creatorcontrib>Kurdyukov, D. A.</creatorcontrib><creatorcontrib>Golubev, V. G.</creatorcontrib><collection>CrossRef</collection><jtitle>Technical physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shmakov, S. V.</au><au>Klimenko, V. V.</au><au>Konyakhin, S. V.</au><au>Eurov, D. A.</au><au>Kurdyukov, D. A.</au><au>Golubev, V. G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation of Toxic Effect and Penetration into Cells of Monodisperse Spherical Composite Particles Based on Mesoporous Silica</atitle><jtitle>Technical physics</jtitle><stitle>Tech. 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3
O
4
and coated with mesoporous silica, the internal surface of which is modified by Fluorescein isothiocyanate (FITC) fluorescence dye by means of chemisorption. The toxicity and penetration of the obtained particles into the cells of the HeLa and K-562 cell lines were studied. The effective photodynamic action of MSMSPs containing Radachlorin in mesopores is demonstrated, which indicates the promise of using the synthesized composite particles for medical purposes.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1063784218090190</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 1063-7842 |
| ispartof | Technical physics, 2018-09, Vol.63 (9), p.1316-1322 |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Chemisorption Classical and Continuum Physics Core-shell structure Development of Process Technologies Diagnostic Methods Dye penetrants Fluorescein Fluorescence Fluorescent dyes Functional Materials and Structures Investigations Iron oxides Organic chemistry Particulate composites Penetration Physics Physics and Astronomy Porous materials Silica Silicon dioxide Synthesis Toxicity |
| title | Investigation of Toxic Effect and Penetration into Cells of Monodisperse Spherical Composite Particles Based on Mesoporous Silica |
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