Liquid biopsy: A potential and promising diagnostic tool for advanced stage non-small cell lung cancer patients
More than 50% of non-small cell lung cancer (NSCLC) cases harbor an actionable mutation, and molecular testing at different intervals can help in personalized and targeted treatment. Core tissue biopsy and needle biopsy done at the time of diagnosis/disease progression are interventional, time-consu...
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| Veröffentlicht in: | Indian journal of cancer 2017-12, Vol.54 (Supplement), p.S25-30 |
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| container_title | Indian journal of cancer |
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| creator | Doval, D C Deshpande, R Dhabhar, B Babu, K G Prabhash, K Chopra, R Sripada, P V Deshmukh, C Suryavanshi, M |
| description | More than 50% of non-small cell lung cancer (NSCLC) cases harbor an actionable mutation, and molecular testing at different intervals can help in personalized and targeted treatment. Core tissue biopsy and needle biopsy done at the time of diagnosis/disease progression are interventional, time-consuming and can affect the patients adversely. Noninterventional biomarker testing by liquid biopsy promises to revolutionize advanced stage cancer screening. The present report was formulated based on an expert panel meeting of renowned oncologists who gave their opinions for minimally invasive liquid biopsy to detect targetable molecular biomarkers in advanced NSCLC cases. An exhaustive literature search was done to support their recommendations. Clinical utility of minimally invasive liquid biopsy, for detection of molecular biomarkers in advanced stage NSCLC patients, was broadly discussed by the key opinion leaders. |
| doi_str_mv | 10.4103/ijc.IJC_514_17 |
| format | Article |
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Core tissue biopsy and needle biopsy done at the time of diagnosis/disease progression are interventional, time-consuming and can affect the patients adversely. Noninterventional biomarker testing by liquid biopsy promises to revolutionize advanced stage cancer screening. The present report was formulated based on an expert panel meeting of renowned oncologists who gave their opinions for minimally invasive liquid biopsy to detect targetable molecular biomarkers in advanced NSCLC cases. An exhaustive literature search was done to support their recommendations. 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| fulltext | fulltext |
| identifier | ISSN: 0019-509X |
| ispartof | Indian journal of cancer, 2017-12, Vol.54 (Supplement), p.S25-30 |
| issn | 0019-509X 1998-4774 |
| language | eng |
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| source | MEDLINE; Medknow Open Access Medical Journals; Bioline International; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Biomarkers Biomarkers, Tumor - blood Cancer screening Cancer therapies Carcinoma, Non-Small-Cell Lung - blood Carcinoma, Non-Small-Cell Lung - pathology Cellular biology Deoxyribonucleic acid DNA Early Detection of Cancer Epidermal growth factor Genetic aspects Humans Kinases Liquid Biopsy Lung cancer Mutation Neoplasm Staging Non-small cell lung cancer Physicians Plasma Small cell lung cancer |
| title | Liquid biopsy: A potential and promising diagnostic tool for advanced stage non-small cell lung cancer patients |
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