FA-PEG decorated MOF nanoparticles as a targeted drug delivery system for controlled release of an autophagy inhibitor

A zeolitic imidazolate framework (ZIF-8) with high loading capacity and pH-responsive properties, an important subclass of metal-organic frameworks (MOFs), has become a promising material for drug delivery. A multifunctional drug delivery system (DDS) was designed in this work for effective targetin...

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Veröffentlicht in:	Biomaterials science 2018-09, Vol.6 (1), p.2582-259
Hauptverfasser:	Shi, Zheqi, Chen, Xuerui, Zhang, Li, Ding, Shiping, Wang, Xu, Lei, Qunfang, Fang, Wenjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy Autophagy - drug effects Cancer Cell Survival - drug effects Chloroquine - administration & dosage Chloroquine - analogs & derivatives Chloroquine - chemistry Controlled release Drug Delivery Systems Drug Liberation Folic acid Folic Acid - administration & dosage Folic Acid - chemistry HEK293 Cells HeLa Cells Humans Inhibitors Metal-organic frameworks Metal-Organic Frameworks - administration & dosage Metal-Organic Frameworks - chemistry Nanoparticles Nanoparticles - administration & dosage Nanoparticles - chemistry Polyethylene glycol Polyethylene Glycols - administration & dosage Polyethylene Glycols - chemistry Proteins Receptors Target recognition Toxicity Zeolites - administration & dosage Zeolites - chemistry Zinc - administration & dosage Zinc - chemistry
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