Lack of dependence of mechanical properties of baicalein cocrystals on those of the constituent components
Commercial baicalein (α form) exhibits deficient tabletability. Cocrystals of baicalein with nicotinamide, caffeine, and isoniazid were all shown to display excellent tabletability, despite the three coformers having high, medium, and poor tabletability, respectively. A crystal structure analysis us...
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| Veröffentlicht in: | CrystEngComm 2018, Vol.20 (37), p.5486-5489 |
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| container_issue | 37 |
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| container_title | CrystEngComm |
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| creator | Liu, Lili Wang, Chenguang Dun, Jiangnan Chow, Albert H. L. Sun, Changquan Calvin |
| description | Commercial baicalein (α form) exhibits deficient tabletability. Cocrystals of baicalein with nicotinamide, caffeine, and isoniazid were all shown to display excellent tabletability, despite the three coformers having high, medium, and poor tabletability, respectively. A crystal structure analysis using the energy framework approach revealed that the superior tabletability of these cocrystals always correlated with structural features rendering high plasticity irrespective of the coformer involved. |
| doi_str_mv | 10.1039/C8CE00787J |
| format | Article |
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L.</creatorcontrib><creatorcontrib>Sun, Changquan Calvin</creatorcontrib><title>Lack of dependence of mechanical properties of baicalein cocrystals on those of the constituent components</title><title>CrystEngComm</title><description>Commercial baicalein (α form) exhibits deficient tabletability. Cocrystals of baicalein with nicotinamide, caffeine, and isoniazid were all shown to display excellent tabletability, despite the three coformers having high, medium, and poor tabletability, respectively. A crystal structure analysis using the energy framework approach revealed that the superior tabletability of these cocrystals always correlated with structural features rendering high plasticity irrespective of the coformer involved.</description><subject>Caffeine</subject><subject>Crystal structure</subject><subject>Crystallography</subject><subject>Dependence</subject><subject>Mechanical properties</subject><subject>Nicotinamide</subject><subject>Structural analysis</subject><issn>1466-8033</issn><issn>1466-8033</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpNUMtOwzAQtBBIlMKFL4jEDSmwtuPEPqKovBSJC5wjx9moKa0dbPfQv8ehSHDa2Z3Z2dUQck3hjgJX97WsVwCVrF5PyIIWZZlL4Pz0Hz4nFyFsAGhBKSzIptHmM3ND1uOEtkdrcO52aNbajkZvs8m7CX0cMcxEp-chjjYzzvhDiHqb5jaLaxd-NuMaE2VDHOMebUx4NzmbULgkZ0NS49VvXZKPx9V7_Zw3b08v9UOTG6bKmCspDRouwWhBgfJeiUJQSoVmTFdKMNMVldSsKw0VrBdsAISqK5kwVVF0JV-Sm6Nv-vxrjyG2G7f3Np1sWfKhoISSSXV7VBnvQvA4tJMfd9ofWgrtnGX7lyX_BmXcZqM</recordid><startdate>2018</startdate><enddate>2018</enddate><creator>Liu, Lili</creator><creator>Wang, Chenguang</creator><creator>Dun, Jiangnan</creator><creator>Chow, Albert H. 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| fulltext | fulltext |
| identifier | ISSN: 1466-8033 |
| ispartof | CrystEngComm, 2018, Vol.20 (37), p.5486-5489 |
| issn | 1466-8033 1466-8033 |
| language | eng |
| recordid | cdi_proquest_journals_2111109598 |
| source | Royal Society Of Chemistry Journals; Alma/SFX Local Collection |
| subjects | Caffeine Crystal structure Crystallography Dependence Mechanical properties Nicotinamide Structural analysis |
| title | Lack of dependence of mechanical properties of baicalein cocrystals on those of the constituent components |
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