Altered cholesterol homeostasis in cultured and in vivo models of cystic fibrosis

Departments of 1 Pediatrics and Pharmacology, 2 Chemistry, and 3 Nutrition, Department of Medicine, Case Western Reserve University and Rainbow Babies and Children's Hospital, Cleveland, Ohio Submitted 13 July 2006 ; accepted in final form 26 October 2006 Determining how the regulation of cellu...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2007-02, Vol.292 (2), p.L476-L486
Hauptverfasser:	White, Nicole M, Jiang, Dechen, Burgess, James D, Bederman, Ilya R, Previs, Stephen F, Kelley, Thomas J
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Chloro-7-nitrobenzofurazan - analogs & derivatives 4-Chloro-7-nitrobenzofurazan - metabolism Animals Biological Transport - drug effects Cell Membrane - drug effects Cell Membrane - metabolism Cells, Cultured Cellular biology Cholesterol Cholesterol - analogs & derivatives Cholesterol - biosynthesis Cholesterol - metabolism Cystic fibrosis Cystic Fibrosis - metabolism Cystic Fibrosis - pathology Cystic Fibrosis Transmembrane Conductance Regulator - deficiency Disease Models, Animal Docosahexaenoic Acids - pharmacology Enzyme Inhibitors - pharmacology Epithelial Cells - drug effects Epithelial Cells - pathology Homeostasis - drug effects Humans Interleukin-6 - biosynthesis Interleukin-6 - secretion Interleukin-8 - biosynthesis Interleukin-8 - secretion Lungs Lysosomal Storage Diseases - pathology Mice Microelectrodes Nitric Oxide Synthase Type II - antagonists & inhibitors Pathology Smad3 Protein - metabolism Throat
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