The Coenzyme Q10 (CoQ10) as Countermeasure for Retinal Damage Onboard the International Space Station: the CORM Project
Cells, tissues and organs of astronauts aboard the International Space Station (ISS) are exposed to the damaging effects of microgravity and cosmic radiation. Space Agencies are forced to find effective therapeutic countermeasures to safeguard astronauts’ health. Since retina is one of the most vuln...
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| Veröffentlicht in: | Microgravity science and technology 2018-12, Vol.30 (6), p.925-931 |
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| creator | Lulli, Matteo Cialdai, Francesca Vignali, Leonardo Monici, Monica Luzzi, Sara Cicconi, Alessandro Cacchione, Stefano Magi, Alberto Di Gesualdo, Federico Balsamo, Michele Vukich, Marco Neri, Gianluca Donati, Alessandro Capaccioli, Sergio |
| description | Cells, tissues and organs of astronauts aboard the International Space Station (ISS) are exposed to the damaging effects of microgravity and cosmic radiation. Space Agencies are forced to find effective therapeutic countermeasures to safeguard astronauts’ health. Since retina is one of the most vulnerable target, we undertook a project entitled
The Coenzyme Q10 (CoQ10) as countermeasure for retinal damage onboard the International Space Station: the CORM project
, funded by the Italian Space Agency (ASI) and launched in the summer 2017. We selected CoQ10 as promising candidate drug, having previously first demonstrated its direct antiapoptotic property due to its ability to inhibit mitochondrial depolarization. Beside apoptosis prevention, the parameters we are measuring to evaluate the therapeutic effectiveness of CoQ10 are attenuation of cytoskeleton modifications, lowering of telomeric DNA damages, and exome and whole transcriptome alterations. Here, we present preliminary on-ground experiments that have been carried out in human retinal pigment epithelial ARPE-19 cells and the experimental design of the CORM experiment aboard the ISS. The results obtained by the CORM project will pave the way to countermeasures for astronauts who will face long-term missions. |
| doi_str_mv | 10.1007/s12217-018-9652-3 |
| format | Article |
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The Coenzyme Q10 (CoQ10) as countermeasure for retinal damage onboard the International Space Station: the CORM project
, funded by the Italian Space Agency (ASI) and launched in the summer 2017. We selected CoQ10 as promising candidate drug, having previously first demonstrated its direct antiapoptotic property due to its ability to inhibit mitochondrial depolarization. Beside apoptosis prevention, the parameters we are measuring to evaluate the therapeutic effectiveness of CoQ10 are attenuation of cytoskeleton modifications, lowering of telomeric DNA damages, and exome and whole transcriptome alterations. Here, we present preliminary on-ground experiments that have been carried out in human retinal pigment epithelial ARPE-19 cells and the experimental design of the CORM experiment aboard the ISS. The results obtained by the CORM project will pave the way to countermeasures for astronauts who will face long-term missions.</description><identifier>ISSN: 0938-0108</identifier><identifier>EISSN: 1875-0494</identifier><identifier>DOI: 10.1007/s12217-018-9652-3</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Aerospace Technology and Astronautics ; Apoptosis ; Astronauts ; Attenuation ; Classical and Continuum Physics ; Cosmic rays ; Deoxyribonucleic acid ; Depolarization ; Design of experiments ; DNA ; Engineering ; Experimental design ; Gravitational effects ; International Space Station ; Microgravity ; Multinational space ventures ; Organs ; Original Article ; Radiation ; Radiation damage ; Retina ; Space Exploration and Astronautics ; Space missions ; Space Sciences (including Extraterrestrial Physics ; Space stations</subject><ispartof>Microgravity science and technology, 2018-12, Vol.30 (6), p.925-931</ispartof><rights>Springer Nature B.V. 2018. corrected publication 2018</rights><rights>Microgravity Science and Technology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-7bd1a5eb59bd87a75c3a1ff65acc5e30bf276bcdae233b4e50bc31464a3291693</citedby><cites>FETCH-LOGICAL-c316t-7bd1a5eb59bd87a75c3a1ff65acc5e30bf276bcdae233b4e50bc31464a3291693</cites><orcidid>0000-0002-8528-4094</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12217-018-9652-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12217-018-9652-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Lulli, Matteo</creatorcontrib><creatorcontrib>Cialdai, Francesca</creatorcontrib><creatorcontrib>Vignali, Leonardo</creatorcontrib><creatorcontrib>Monici, Monica</creatorcontrib><creatorcontrib>Luzzi, Sara</creatorcontrib><creatorcontrib>Cicconi, Alessandro</creatorcontrib><creatorcontrib>Cacchione, Stefano</creatorcontrib><creatorcontrib>Magi, Alberto</creatorcontrib><creatorcontrib>Di Gesualdo, Federico</creatorcontrib><creatorcontrib>Balsamo, Michele</creatorcontrib><creatorcontrib>Vukich, Marco</creatorcontrib><creatorcontrib>Neri, Gianluca</creatorcontrib><creatorcontrib>Donati, Alessandro</creatorcontrib><creatorcontrib>Capaccioli, Sergio</creatorcontrib><title>The Coenzyme Q10 (CoQ10) as Countermeasure for Retinal Damage Onboard the International Space Station: the CORM Project</title><title>Microgravity science and technology</title><addtitle>Microgravity Sci. Technol</addtitle><description>Cells, tissues and organs of astronauts aboard the International Space Station (ISS) are exposed to the damaging effects of microgravity and cosmic radiation. Space Agencies are forced to find effective therapeutic countermeasures to safeguard astronauts’ health. Since retina is one of the most vulnerable target, we undertook a project entitled
The Coenzyme Q10 (CoQ10) as countermeasure for retinal damage onboard the International Space Station: the CORM project
, funded by the Italian Space Agency (ASI) and launched in the summer 2017. We selected CoQ10 as promising candidate drug, having previously first demonstrated its direct antiapoptotic property due to its ability to inhibit mitochondrial depolarization. Beside apoptosis prevention, the parameters we are measuring to evaluate the therapeutic effectiveness of CoQ10 are attenuation of cytoskeleton modifications, lowering of telomeric DNA damages, and exome and whole transcriptome alterations. Here, we present preliminary on-ground experiments that have been carried out in human retinal pigment epithelial ARPE-19 cells and the experimental design of the CORM experiment aboard the ISS. 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Onboard the International Space Station: the CORM Project</atitle><jtitle>Microgravity science and technology</jtitle><stitle>Microgravity Sci. Technol</stitle><date>2018-12-01</date><risdate>2018</risdate><volume>30</volume><issue>6</issue><spage>925</spage><epage>931</epage><pages>925-931</pages><issn>0938-0108</issn><eissn>1875-0494</eissn><abstract>Cells, tissues and organs of astronauts aboard the International Space Station (ISS) are exposed to the damaging effects of microgravity and cosmic radiation. Space Agencies are forced to find effective therapeutic countermeasures to safeguard astronauts’ health. Since retina is one of the most vulnerable target, we undertook a project entitled
The Coenzyme Q10 (CoQ10) as countermeasure for retinal damage onboard the International Space Station: the CORM project
, funded by the Italian Space Agency (ASI) and launched in the summer 2017. We selected CoQ10 as promising candidate drug, having previously first demonstrated its direct antiapoptotic property due to its ability to inhibit mitochondrial depolarization. Beside apoptosis prevention, the parameters we are measuring to evaluate the therapeutic effectiveness of CoQ10 are attenuation of cytoskeleton modifications, lowering of telomeric DNA damages, and exome and whole transcriptome alterations. Here, we present preliminary on-ground experiments that have been carried out in human retinal pigment epithelial ARPE-19 cells and the experimental design of the CORM experiment aboard the ISS. The results obtained by the CORM project will pave the way to countermeasures for astronauts who will face long-term missions.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><doi>10.1007/s12217-018-9652-3</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-8528-4094</orcidid></addata></record> |
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| subjects | Aerospace Technology and Astronautics Apoptosis Astronauts Attenuation Classical and Continuum Physics Cosmic rays Deoxyribonucleic acid Depolarization Design of experiments DNA Engineering Experimental design Gravitational effects International Space Station Microgravity Multinational space ventures Organs Original Article Radiation Radiation damage Retina Space Exploration and Astronautics Space missions Space Sciences (including Extraterrestrial Physics Space stations |
| title | The Coenzyme Q10 (CoQ10) as Countermeasure for Retinal Damage Onboard the International Space Station: the CORM Project |
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