SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate

Targeted protein degradation via small-molecule modulation of cereblon offers vast potential for the development of new therapeutics. Cereblon-binding therapeutics carry the safety risks of thalidomide, which caused an epidemic of severe birth defects characterized by forelimb shortening or phocomel...

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Veröffentlicht in:	Nature chemical biology 2018-10, Vol.14 (10), p.981-987
Hauptverfasser:	Matyskiela, Mary E., Couto, Suzana, Zheng, Xinde, Lu, Gang, Hui, Julia, Stamp, Katie, Drew, Clifton, Ren, Yan, Wang, Maria, Carpenter, Aaron, Lee, Chung-Wein, Clayton, Thomas, Fang, Wei, Lu, Chin-Chun, Riley, Mariko, Abdubek, Polat, Blease, Kate, Hartke, James, Kumar, Gondi, Vessey, Rupert, Rolfe, Mark, Hamann, Lawrence G., Chamberlain, Philip P.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/334/1874 631/154 631/154/570 631/92/556 Animals Binding Biochemical Engineering Biochemistry Biodegradation Bioorganic Chemistry Birth Birth defects Cell Biology Chemistry Chemistry and Materials Science Chemistry/Food Science Congenital defects DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics Drug development Epidemics Gene Expression Regulation Homozygote Humans Immunohistochemistry Induced Pluripotent Stem Cells Ligands Male Mice Mice, Transgenic Mutation Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - genetics Peptide Hydrolases - chemistry Peptide Hydrolases - genetics Phocomelia Proteolysis Rabbits Substrates Teratogenicity Teratogens - chemistry Testis - metabolism Thalidomide Thalidomide - chemistry Transcription Factors - chemistry Transcription Factors - genetics Transgenic mice Ubiquitin-Protein Ligases - metabolism Zinc finger proteins Zinc Fingers
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