Probiotics to Prevent Clostridium difficile Infection in Patients Receiving Antibiotics

CLINICAL QUESTION: In adults and children prescribed antibiotics, is co-administration of a probiotic associated with a lower risk of symptomatic Clostridium difficile infection without an increase in adverse events? BOTTOM LINE: Moderate-quality evidence suggests that probiotics are associated with...

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Veröffentlicht in:	JAMA : the journal of the American Medical Association 2018-08, Vol.320 (5), p.499-500
Hauptverfasser:	Goldenberg, Joshua Z, Mertz, Dominik, Johnston, Bradley C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - therapeutic use Antibiotics Bacterial infections Child Clostridioides difficile Clostridium Infections - prevention & control Humans Immunocompromised Host Patients Practice Guidelines as Topic Probiotics Probiotics - therapeutic use Review Literature as Topic
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creator	Goldenberg, Joshua Z Mertz, Dominik Johnston, Bradley C
description	CLINICAL QUESTION: In adults and children prescribed antibiotics, is co-administration of a probiotic associated with a lower risk of symptomatic Clostridium difficile infection without an increase in adverse events? BOTTOM LINE: Moderate-quality evidence suggests that probiotics are associated with a lower risk of C difficile infection and very low–quality evidence suggests that probiotics are associated with fewer adverse events vs placebo or no treatment.
doi_str_mv	10.1001/jama.2018.9064
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subjects	Adult Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - therapeutic use Antibiotics Bacterial infections Child Clostridioides difficile Clostridium Infections - prevention & control Humans Immunocompromised Host Patients Practice Guidelines as Topic Probiotics Probiotics - therapeutic use Review Literature as Topic
title	Probiotics to Prevent Clostridium difficile Infection in Patients Receiving Antibiotics
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