Protective effects of magnesium sulfate against doxorubicin induced cardiotoxicity in rats
Clinical use of doxorubicin, an effective chemotherapeutic agent, has limited uses due to dose-dependent cardiac toxicity. It has been supposed that the production of free radicals and calcium ions overload can lead to cardiac toxicity. Magnesium is a cardioprotective drug which inhibits lipid perox...
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| Veröffentlicht in: | Life sciences (1973) 2018-08, Vol.207, p.436-441 |
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| creator | Khalilzadeh, Mina Abdollahi, Alireza Abdolahi, Farhad Abdolghaffari, Amir Hossein Dehpour, Ahmad Reza Jazaeri, Farahnaz |
| description | Clinical use of doxorubicin, an effective chemotherapeutic agent, has limited uses due to dose-dependent cardiac toxicity. It has been supposed that the production of free radicals and calcium ions overload can lead to cardiac toxicity. Magnesium is a cardioprotective drug which inhibits lipid peroxidation and reducing myocardial apoptosis. This study was aimed to explore the hypothesis that the cardiac toxicity induced by administration of doxorubicin is prevented or reduced by magnesium sulfate treatment and if so, whether this is associated with altered oxidative stress response in heart.
Male Wistar rats were intraperitoneally injected with doxorubicin and magnesium sulfate and normal saline four times per week for 2 consecutive weeks. Then electrocardiographic, inotropic and biochemical tests were performed.
Co-administration of magnesium sulfate with doxorubicin significantly reversed alterations in the stimulation threshold and contractile force induced by doxorubicin. In addition, magnesium sulfate improved body weight loss and alleviated the mortality rate of animals induced by doxorubicin. Moreover, it was observed that lesions induced by doxorubicin decreased in animals treated with magnesium sulfate. Magnesium sulfate significantly increased Glutathione (GSH) in doxorubicin treated animals.
In conclusion, the results of the present study demonstrated that magnesium sulfate attenuate the cardio toxic effects of doxorubicin by increasing the activities of the antioxidants enzyme. |
| doi_str_mv | 10.1016/j.lfs.2018.06.022 |
| format | Article |
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Male Wistar rats were intraperitoneally injected with doxorubicin and magnesium sulfate and normal saline four times per week for 2 consecutive weeks. Then electrocardiographic, inotropic and biochemical tests were performed.
Co-administration of magnesium sulfate with doxorubicin significantly reversed alterations in the stimulation threshold and contractile force induced by doxorubicin. In addition, magnesium sulfate improved body weight loss and alleviated the mortality rate of animals induced by doxorubicin. Moreover, it was observed that lesions induced by doxorubicin decreased in animals treated with magnesium sulfate. Magnesium sulfate significantly increased Glutathione (GSH) in doxorubicin treated animals.
In conclusion, the results of the present study demonstrated that magnesium sulfate attenuate the cardio toxic effects of doxorubicin by increasing the activities of the antioxidants enzyme.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/j.lfs.2018.06.022</identifier><identifier>PMID: 29940240</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Antioxidants ; Apoptosis ; Biochemical tests ; Body weight ; Body weight loss ; Calcium ions ; Cardiotoxicity ; Doxorubicin ; ECG ; Free radicals ; Glutathione ; Heart ; Lipid peroxidation ; Lipids ; Magnesium ; Magnesium sulfate ; Muscle contraction ; Oxidative stress ; Papillary muscle ; Peroxidation ; Rats ; Rodents ; Sulfates ; Toxicity ; Weight loss</subject><ispartof>Life sciences (1973), 2018-08, Vol.207, p.436-441</ispartof><rights>2018 Elsevier Inc.</rights><rights>Copyright © 2018. Published by Elsevier Inc.</rights><rights>Copyright Elsevier BV Aug 15, 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-cd1c82545d974a0e7fc0e276e6bab1589e941b2904308685bed3a049eaaa1fd53</citedby><cites>FETCH-LOGICAL-c381t-cd1c82545d974a0e7fc0e276e6bab1589e941b2904308685bed3a049eaaa1fd53</cites><orcidid>0000-0001-8392-9795 ; 0000-0002-8001-5565</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.lfs.2018.06.022$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29940240$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khalilzadeh, Mina</creatorcontrib><creatorcontrib>Abdollahi, Alireza</creatorcontrib><creatorcontrib>Abdolahi, Farhad</creatorcontrib><creatorcontrib>Abdolghaffari, Amir Hossein</creatorcontrib><creatorcontrib>Dehpour, Ahmad Reza</creatorcontrib><creatorcontrib>Jazaeri, Farahnaz</creatorcontrib><title>Protective effects of magnesium sulfate against doxorubicin induced cardiotoxicity in rats</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Clinical use of doxorubicin, an effective chemotherapeutic agent, has limited uses due to dose-dependent cardiac toxicity. It has been supposed that the production of free radicals and calcium ions overload can lead to cardiac toxicity. Magnesium is a cardioprotective drug which inhibits lipid peroxidation and reducing myocardial apoptosis. This study was aimed to explore the hypothesis that the cardiac toxicity induced by administration of doxorubicin is prevented or reduced by magnesium sulfate treatment and if so, whether this is associated with altered oxidative stress response in heart.
Male Wistar rats were intraperitoneally injected with doxorubicin and magnesium sulfate and normal saline four times per week for 2 consecutive weeks. Then electrocardiographic, inotropic and biochemical tests were performed.
Co-administration of magnesium sulfate with doxorubicin significantly reversed alterations in the stimulation threshold and contractile force induced by doxorubicin. In addition, magnesium sulfate improved body weight loss and alleviated the mortality rate of animals induced by doxorubicin. Moreover, it was observed that lesions induced by doxorubicin decreased in animals treated with magnesium sulfate. Magnesium sulfate significantly increased Glutathione (GSH) in doxorubicin treated animals.
In conclusion, the results of the present study demonstrated that magnesium sulfate attenuate the cardio toxic effects of doxorubicin by increasing the activities of the antioxidants enzyme.</description><subject>Animals</subject><subject>Antioxidants</subject><subject>Apoptosis</subject><subject>Biochemical tests</subject><subject>Body weight</subject><subject>Body weight loss</subject><subject>Calcium ions</subject><subject>Cardiotoxicity</subject><subject>Doxorubicin</subject><subject>ECG</subject><subject>Free radicals</subject><subject>Glutathione</subject><subject>Heart</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Magnesium</subject><subject>Magnesium sulfate</subject><subject>Muscle contraction</subject><subject>Oxidative stress</subject><subject>Papillary muscle</subject><subject>Peroxidation</subject><subject>Rats</subject><subject>Rodents</subject><subject>Sulfates</subject><subject>Toxicity</subject><subject>Weight loss</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kD1LBDEQhoMoep7-ABsJWO86yW72AysRv0DQQhubkE0mkuNuo0lWzn9vjlNLqxkmz7xDHkJOGJQMWHO-KJc2lhxYV0JTAuc7ZMa6ti-gqdgumQHwuqg4iANyGOMCAIRoq31ywPu-zm8wI69PwSfUyX0iRWtzF6m3dKXeRoxuWtE4La1KSNWbcmNM1Pi1D9PgtBupG82k0VCtgnE--XWepq88pkGleET2rFpGPP6pc_Jyc_18dVc8PN7eX10-FLrqWCq0Ybrjohamb2sF2FoNyNsGm0ENTHQ99jUbeA91BV3TiQFNpaDuUSnFrBHVnJxtc9-D_5gwJrnwUxjzSclZBgVreJ0ptqV08DEGtPI9uJUKX5KB3NiUC5ltyo1NCY3MNvPO6U_yNKzQ_G386svAxRbA_L9Ph0FG7XDMTlzIKqXx7p_4b1BkhlQ</recordid><startdate>20180815</startdate><enddate>20180815</enddate><creator>Khalilzadeh, Mina</creator><creator>Abdollahi, Alireza</creator><creator>Abdolahi, Farhad</creator><creator>Abdolghaffari, Amir Hossein</creator><creator>Dehpour, Ahmad Reza</creator><creator>Jazaeri, Farahnaz</creator><general>Elsevier Inc</general><general>Elsevier BV</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><orcidid>https://orcid.org/0000-0001-8392-9795</orcidid><orcidid>https://orcid.org/0000-0002-8001-5565</orcidid></search><sort><creationdate>20180815</creationdate><title>Protective effects of magnesium sulfate against doxorubicin induced cardiotoxicity in rats</title><author>Khalilzadeh, Mina ; Abdollahi, Alireza ; Abdolahi, Farhad ; Abdolghaffari, Amir Hossein ; Dehpour, Ahmad Reza ; Jazaeri, Farahnaz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-cd1c82545d974a0e7fc0e276e6bab1589e941b2904308685bed3a049eaaa1fd53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Antioxidants</topic><topic>Apoptosis</topic><topic>Biochemical tests</topic><topic>Body weight</topic><topic>Body weight loss</topic><topic>Calcium ions</topic><topic>Cardiotoxicity</topic><topic>Doxorubicin</topic><topic>ECG</topic><topic>Free radicals</topic><topic>Glutathione</topic><topic>Heart</topic><topic>Lipid peroxidation</topic><topic>Lipids</topic><topic>Magnesium</topic><topic>Magnesium sulfate</topic><topic>Muscle contraction</topic><topic>Oxidative stress</topic><topic>Papillary muscle</topic><topic>Peroxidation</topic><topic>Rats</topic><topic>Rodents</topic><topic>Sulfates</topic><topic>Toxicity</topic><topic>Weight loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khalilzadeh, Mina</creatorcontrib><creatorcontrib>Abdollahi, Alireza</creatorcontrib><creatorcontrib>Abdolahi, Farhad</creatorcontrib><creatorcontrib>Abdolghaffari, Amir Hossein</creatorcontrib><creatorcontrib>Dehpour, Ahmad Reza</creatorcontrib><creatorcontrib>Jazaeri, Farahnaz</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khalilzadeh, Mina</au><au>Abdollahi, Alireza</au><au>Abdolahi, Farhad</au><au>Abdolghaffari, Amir Hossein</au><au>Dehpour, Ahmad Reza</au><au>Jazaeri, Farahnaz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effects of magnesium sulfate against doxorubicin induced cardiotoxicity in rats</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>2018-08-15</date><risdate>2018</risdate><volume>207</volume><spage>436</spage><epage>441</epage><pages>436-441</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Clinical use of doxorubicin, an effective chemotherapeutic agent, has limited uses due to dose-dependent cardiac toxicity. It has been supposed that the production of free radicals and calcium ions overload can lead to cardiac toxicity. Magnesium is a cardioprotective drug which inhibits lipid peroxidation and reducing myocardial apoptosis. This study was aimed to explore the hypothesis that the cardiac toxicity induced by administration of doxorubicin is prevented or reduced by magnesium sulfate treatment and if so, whether this is associated with altered oxidative stress response in heart.
Male Wistar rats were intraperitoneally injected with doxorubicin and magnesium sulfate and normal saline four times per week for 2 consecutive weeks. Then electrocardiographic, inotropic and biochemical tests were performed.
Co-administration of magnesium sulfate with doxorubicin significantly reversed alterations in the stimulation threshold and contractile force induced by doxorubicin. In addition, magnesium sulfate improved body weight loss and alleviated the mortality rate of animals induced by doxorubicin. Moreover, it was observed that lesions induced by doxorubicin decreased in animals treated with magnesium sulfate. Magnesium sulfate significantly increased Glutathione (GSH) in doxorubicin treated animals.
In conclusion, the results of the present study demonstrated that magnesium sulfate attenuate the cardio toxic effects of doxorubicin by increasing the activities of the antioxidants enzyme.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>29940240</pmid><doi>10.1016/j.lfs.2018.06.022</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-8392-9795</orcidid><orcidid>https://orcid.org/0000-0002-8001-5565</orcidid></addata></record> |
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| subjects | Animals Antioxidants Apoptosis Biochemical tests Body weight Body weight loss Calcium ions Cardiotoxicity Doxorubicin ECG Free radicals Glutathione Heart Lipid peroxidation Lipids Magnesium Magnesium sulfate Muscle contraction Oxidative stress Papillary muscle Peroxidation Rats Rodents Sulfates Toxicity Weight loss |
| title | Protective effects of magnesium sulfate against doxorubicin induced cardiotoxicity in rats |
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