BIABooster: Online DNA Concentration and Size Profiling with a Limit of Detection of 10 fg/µL and Application to High-Sensitivity Characterization of Circulating Cell-Free DNA

We describe a technology to perform sizing and concentration analysis of double stranded DNA with a sensitivity of 10 fg/μL in an operating time of 20 min. The technology is operated automatically on a commercial capillary electrophoresis instrument using electro-hydrodynamic actuation. It relies on...

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Veröffentlicht in:	Analytical chemistry (Washington) 2018-03, Vol.90 (6), p.3766
Hauptverfasser:	Andriamanampisoa, Comtet-Louis, Bancaud, Aurélien, Boutonnet-Rodat, Audrey, Didelot, Audrey, Fabre, Jacques, Fina, Frédéric, Garlan, Fanny, Garrigou, Sonia, Gaudy, Caroline, Ginot, Frédéric, Henaff, Daniel, Laurent-Puig, Pierre, Morin, Arnaud, Picot, Vincent, Saias, Laure, Taly, Valérie, Tomasini, Pascale, Zaanan, Aziz
Format:	Artikel
Sprache:	eng
Schlagworte:	Actuation Analytical chemistry Biomarkers Blood vessels Capillaries Chemistry Correlation analysis Deoxyribonucleic acid Digital technology DNA DNA polymerase Electrophoresis Ladders Low molecular weights Molecular weight Polymerase chain reaction Sensitivity analysis Sizing Technology assessment Viscoelasticity
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