Type 2 Diabetes Mellitus and Cognitive Decline in Two Large Cohorts of Community-Dwelling Older Adults
OBJECTIVES: To relate diabetes mellitus (DM) status and duration to late‐life cognitive impairment and decline in men and women. DESIGN: Prospective cohort. SETTING: Community. PARTICIPANTS: Five thousand nine hundred seven men in the Physicians' Health Study II and 6,326 women in the Women...
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| Veröffentlicht in: | Journal of the American Geriatrics Society (JAGS) 2008-06, Vol.56 (6), p.1028-1036 |
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| container_title | Journal of the American Geriatrics Society (JAGS) |
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| creator | Okereke, Olivia I. Kang, Jae H. Cook, Nancy R. Gaziano, J. Michael Manson, JoAnn E. Buring, Julie E. Grodstein, Francine |
| description | OBJECTIVES: To relate diabetes mellitus (DM) status and duration to late‐life cognitive impairment and decline in men and women.
DESIGN: Prospective cohort.
SETTING: Community.
PARTICIPANTS: Five thousand nine hundred seven men in the Physicians' Health Study II and 6,326 women in the Women's Health Study (mean age 74.1 and 71.9, respectively, at baseline cognitive assessment); 553 men and 405 women had DM.
MEASUREMENTS: Primary outcomes were general cognition (the Telephone Interview for Cognitive Status (TICS) and a global score averaging five tests) and verbal memory. All participants had second assessments approximately 2 years later; women had third assessments an average of 4 years later.
RESULTS: In adjusted linear regression models, participants with DM had significantly lower baseline scores for all outcomes, and longer duration of DM was associated with lower scores (P‐trends |
| doi_str_mv | 10.1111/j.1532-5415.2008.01686.x |
| format | Article |
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DESIGN: Prospective cohort.
SETTING: Community.
PARTICIPANTS: Five thousand nine hundred seven men in the Physicians' Health Study II and 6,326 women in the Women's Health Study (mean age 74.1 and 71.9, respectively, at baseline cognitive assessment); 553 men and 405 women had DM.
MEASUREMENTS: Primary outcomes were general cognition (the Telephone Interview for Cognitive Status (TICS) and a global score averaging five tests) and verbal memory. All participants had second assessments approximately 2 years later; women had third assessments an average of 4 years later.
RESULTS: In adjusted linear regression models, participants with DM had significantly lower baseline scores for all outcomes, and longer duration of DM was associated with lower scores (P‐trends <.001). Men with DM had significantly greater 2‐year cognitive decline than men without DM, and longer duration of DM was associated with worse decline (P‐trends ≤.01). In repeated‐measures analyses of response profiles, women with DM had significantly greater 4‐year cognitive decline in all outcomes than women without DM. In women, as in men, there was generally greater cognitive decline with longer duration of DM (e.g., the adjusted mean difference in decline on the TICS associated with duration of ≥5 years was −0.74 (95% confidence interval=−1.05 to −0.43) points (P‐trend <.001). There were no significant sex–DM interactions.
CONCLUSION: Type 2 DM and longer duration of DM are similarly related to cognitive impairment and decline in men and women.</description><identifier>ISSN: 0002-8614</identifier><identifier>EISSN: 1532-5415</identifier><identifier>DOI: 10.1111/j.1532-5415.2008.01686.x</identifier><identifier>PMID: 18384580</identifier><identifier>CODEN: JAGSAF</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Aged ; aging ; Biological and medical sciences ; Cognition & reasoning ; Cognition Disorders - epidemiology ; Cognition Disorders - etiology ; cognitive decline ; Cross-Sectional Studies ; dementia ; Diabetes ; diabetes mellitus ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes. Impaired glucose tolerance ; Effects ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; gender ; General aspects ; Humans ; Linear Models ; Male ; Medical sciences ; Miscellaneous ; Older people ; Prospective Studies ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk Factors ; Sex Distribution ; Time Factors ; United States - epidemiology</subject><ispartof>Journal of the American Geriatrics Society (JAGS), 2008-06, Vol.56 (6), p.1028-1036</ispartof><rights>2008, Copyright the Authors. Journal compilation © 2008, The American Geriatrics Society</rights><rights>2008 INIST-CNRS</rights><rights>Journal compilation 2008 The American Geriatrics Society/Blackwell Publishing</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4976-3a52e8e5cee150b25df49136061c76d9062677c694aa1f3ce45b10414f3264e53</citedby><cites>FETCH-LOGICAL-c4976-3a52e8e5cee150b25df49136061c76d9062677c694aa1f3ce45b10414f3264e53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1532-5415.2008.01686.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1532-5415.2008.01686.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20593130$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18384580$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okereke, Olivia I.</creatorcontrib><creatorcontrib>Kang, Jae H.</creatorcontrib><creatorcontrib>Cook, Nancy R.</creatorcontrib><creatorcontrib>Gaziano, J. Michael</creatorcontrib><creatorcontrib>Manson, JoAnn E.</creatorcontrib><creatorcontrib>Buring, Julie E.</creatorcontrib><creatorcontrib>Grodstein, Francine</creatorcontrib><title>Type 2 Diabetes Mellitus and Cognitive Decline in Two Large Cohorts of Community-Dwelling Older Adults</title><title>Journal of the American Geriatrics Society (JAGS)</title><addtitle>J Am Geriatr Soc</addtitle><description>OBJECTIVES: To relate diabetes mellitus (DM) status and duration to late‐life cognitive impairment and decline in men and women.
DESIGN: Prospective cohort.
SETTING: Community.
PARTICIPANTS: Five thousand nine hundred seven men in the Physicians' Health Study II and 6,326 women in the Women's Health Study (mean age 74.1 and 71.9, respectively, at baseline cognitive assessment); 553 men and 405 women had DM.
MEASUREMENTS: Primary outcomes were general cognition (the Telephone Interview for Cognitive Status (TICS) and a global score averaging five tests) and verbal memory. All participants had second assessments approximately 2 years later; women had third assessments an average of 4 years later.
RESULTS: In adjusted linear regression models, participants with DM had significantly lower baseline scores for all outcomes, and longer duration of DM was associated with lower scores (P‐trends <.001). Men with DM had significantly greater 2‐year cognitive decline than men without DM, and longer duration of DM was associated with worse decline (P‐trends ≤.01). In repeated‐measures analyses of response profiles, women with DM had significantly greater 4‐year cognitive decline in all outcomes than women without DM. In women, as in men, there was generally greater cognitive decline with longer duration of DM (e.g., the adjusted mean difference in decline on the TICS associated with duration of ≥5 years was −0.74 (95% confidence interval=−1.05 to −0.43) points (P‐trend <.001). There were no significant sex–DM interactions.
CONCLUSION: Type 2 DM and longer duration of DM are similarly related to cognitive impairment and decline in men and women.</description><subject>Aged</subject><subject>aging</subject><subject>Biological and medical sciences</subject><subject>Cognition & reasoning</subject><subject>Cognition Disorders - epidemiology</subject><subject>Cognition Disorders - etiology</subject><subject>cognitive decline</subject><subject>Cross-Sectional Studies</subject><subject>dementia</subject><subject>Diabetes</subject><subject>diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Effects</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>gender</subject><subject>General aspects</subject><subject>Humans</subject><subject>Linear Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Older people</subject><subject>Prospective Studies</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Risk Factors</subject><subject>Sex Distribution</subject><subject>Time Factors</subject><subject>United States - epidemiology</subject><issn>0002-8614</issn><issn>1532-5415</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM2O0zAURi0EYsrAKyALiWWC_-MsWAwtU0CFWUxHLC3XuSkuaVLshLZvj0Orzna88ZXu-T5bByFMSU7T-bDJqeQsk4LKnBGic0KVVvnhGZpcFs_RhBDCMq2ouEKvYtwQQhnR-iW6opprITWZoHp53AFmeObtCnqI-Ds0je-HiG1b4Wm3bn3v_wKegWt8C9i3eLnv8MKGNaT1ry70EXd1GrfbIbHHbLYfG9o1vmsqCPimGpo-vkYvattEeHO-r9HD7efl9Eu2uJt_nd4sMifKQmXcSgYapAOgkqyYrGpRUq6Ioq5QVUkUU0XhVCmspTV3IOSKEkFFzZkSIPk1enfq3YXuzwCxN5tuCG160jBKeJEs8QTpE-RCF2OA2uyC39pwNJSY0a_ZmFGjGTWa0a_579ccUvTtuX9YbaF6DJ6FJuD9GbDR2aYOtnU-XjhGZMkpH7mPJ27vGzg--QPm2_x-nFI-O-V97OFwydvw26iCF9L8_DE3s0-KMTq9NQX_B-puou8</recordid><startdate>200806</startdate><enddate>200806</enddate><creator>Okereke, Olivia I.</creator><creator>Kang, Jae H.</creator><creator>Cook, Nancy R.</creator><creator>Gaziano, J. Michael</creator><creator>Manson, JoAnn E.</creator><creator>Buring, Julie E.</creator><creator>Grodstein, Francine</creator><general>Blackwell Publishing Inc</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>200806</creationdate><title>Type 2 Diabetes Mellitus and Cognitive Decline in Two Large Cohorts of Community-Dwelling Older Adults</title><author>Okereke, Olivia I. ; Kang, Jae H. ; Cook, Nancy R. ; Gaziano, J. Michael ; Manson, JoAnn E. ; Buring, Julie E. ; Grodstein, Francine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4976-3a52e8e5cee150b25df49136061c76d9062677c694aa1f3ce45b10414f3264e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>aging</topic><topic>Biological and medical sciences</topic><topic>Cognition & reasoning</topic><topic>Cognition Disorders - epidemiology</topic><topic>Cognition Disorders - etiology</topic><topic>cognitive decline</topic><topic>Cross-Sectional Studies</topic><topic>dementia</topic><topic>Diabetes</topic><topic>diabetes mellitus</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Effects</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>gender</topic><topic>General aspects</topic><topic>Humans</topic><topic>Linear Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Older people</topic><topic>Prospective Studies</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Risk Factors</topic><topic>Sex Distribution</topic><topic>Time Factors</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okereke, Olivia I.</creatorcontrib><creatorcontrib>Kang, Jae H.</creatorcontrib><creatorcontrib>Cook, Nancy R.</creatorcontrib><creatorcontrib>Gaziano, J. Michael</creatorcontrib><creatorcontrib>Manson, JoAnn E.</creatorcontrib><creatorcontrib>Buring, Julie E.</creatorcontrib><creatorcontrib>Grodstein, Francine</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okereke, Olivia I.</au><au>Kang, Jae H.</au><au>Cook, Nancy R.</au><au>Gaziano, J. Michael</au><au>Manson, JoAnn E.</au><au>Buring, Julie E.</au><au>Grodstein, Francine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Type 2 Diabetes Mellitus and Cognitive Decline in Two Large Cohorts of Community-Dwelling Older Adults</atitle><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle><addtitle>J Am Geriatr Soc</addtitle><date>2008-06</date><risdate>2008</risdate><volume>56</volume><issue>6</issue><spage>1028</spage><epage>1036</epage><pages>1028-1036</pages><issn>0002-8614</issn><eissn>1532-5415</eissn><coden>JAGSAF</coden><abstract>OBJECTIVES: To relate diabetes mellitus (DM) status and duration to late‐life cognitive impairment and decline in men and women.
DESIGN: Prospective cohort.
SETTING: Community.
PARTICIPANTS: Five thousand nine hundred seven men in the Physicians' Health Study II and 6,326 women in the Women's Health Study (mean age 74.1 and 71.9, respectively, at baseline cognitive assessment); 553 men and 405 women had DM.
MEASUREMENTS: Primary outcomes were general cognition (the Telephone Interview for Cognitive Status (TICS) and a global score averaging five tests) and verbal memory. All participants had second assessments approximately 2 years later; women had third assessments an average of 4 years later.
RESULTS: In adjusted linear regression models, participants with DM had significantly lower baseline scores for all outcomes, and longer duration of DM was associated with lower scores (P‐trends <.001). Men with DM had significantly greater 2‐year cognitive decline than men without DM, and longer duration of DM was associated with worse decline (P‐trends ≤.01). In repeated‐measures analyses of response profiles, women with DM had significantly greater 4‐year cognitive decline in all outcomes than women without DM. In women, as in men, there was generally greater cognitive decline with longer duration of DM (e.g., the adjusted mean difference in decline on the TICS associated with duration of ≥5 years was −0.74 (95% confidence interval=−1.05 to −0.43) points (P‐trend <.001). There were no significant sex–DM interactions.
CONCLUSION: Type 2 DM and longer duration of DM are similarly related to cognitive impairment and decline in men and women.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>18384580</pmid><doi>10.1111/j.1532-5415.2008.01686.x</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of the American Geriatrics Society (JAGS), 2008-06, Vol.56 (6), p.1028-1036 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged aging Biological and medical sciences Cognition & reasoning Cognition Disorders - epidemiology Cognition Disorders - etiology cognitive decline Cross-Sectional Studies dementia Diabetes diabetes mellitus Diabetes Mellitus, Type 2 - epidemiology Diabetes. Impaired glucose tolerance Effects Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female gender General aspects Humans Linear Models Male Medical sciences Miscellaneous Older people Prospective Studies Public health. Hygiene Public health. Hygiene-occupational medicine Risk Factors Sex Distribution Time Factors United States - epidemiology |
| title | Type 2 Diabetes Mellitus and Cognitive Decline in Two Large Cohorts of Community-Dwelling Older Adults |
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