T Cells Isolated from Positive Epicutaneous Test Reactions to Amoxicillin and Ceftriaxone are Drug Specific and Cytotoxic

In order to investigate the function of T cells in cutaneous adverse drug reactions, skin-derived T cells were analyzed in two patients with a drug-induced exanthem. Skin biopsy specimens were obtained from positive epicutaneous test reactions to amoxicillin and ceftriaxone. Immunohistochemical anal...

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Veröffentlicht in:	Journal of investigative dermatology 2000-10, Vol.115 (4), p.647-652
Hauptverfasser:	Yawalkar, Nikhil, Hari, Yvonne, Frutig, Karin, Egli, Fabienne, Wendland, Thomas, Braathen, Lasse R., Pichler, Werner J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Amoxicillin - adverse effects Biological and medical sciences Ceftriaxone - adverse effects Cell Separation Clone Cells cytokines cytotoxicity Cytotoxicity, Immunologic drug allergy Drug Eruptions - etiology Drug Eruptions - immunology Drug Eruptions - pathology Drug Hypersensitivity - immunology Drug toxicity and drugs side effects treatment Female Humans immunochemistry Interleukin-5 - metabolism Medical sciences Membrane Glycoproteins - immunology Perforin Pharmacology. Drug treatments Pore Forming Cytotoxic Proteins skin Skin Tests T lymphocytes T-Lymphocytes - cytology T-Lymphocytes - drug effects Toxicity: skin, dermoskeleton
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