4-Nitroquinoline-1-Oxide-Induced Mutagen Sensitivity and Risk of Nonmelanoma Skin Cancer: A Case–Control Analysis

The UV radiation-mimetic chemical 4-nitroquinoline-1-oxide (4-NQO) is thought to induce squamous cell carcinoma (SCC) similar to those induced by UV radiation in animals. Therefore, we tested the hypothesis that cellular sensitivity to 4-NQO is associated with risk of developing skin cancer in a cas...

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Veröffentlicht in:	Journal of investigative dermatology 2007-01, Vol.127 (1), p.196-205
Hauptverfasser:	Wang, Li-E, Hsu, T.C., Xiong, Ping, Strom, Sara S., Duvic, Madeleine, Clayman, Gary L., Weber, Randal S., Lippman, Scott M., Goldberg, Leonard H., Wei, Qingyi
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Nitroquinoline-1-oxide - toxicity Adult Aged Aged, 80 and over Biological and medical sciences Carcinoma, Basal Cell - etiology Carcinoma, Squamous Cell - etiology Case-Control Studies Chromosome Breakage Dermatology Female Humans Male Medical sciences Middle Aged Multivariate Analysis Mutagens - toxicity Risk Factors Skin Neoplasms - etiology Tumors of the skin and soft tissue. Premalignant lesions Ultraviolet Rays
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