α-Arylation of alkylamines with sulfonylarenes through a radical chain mechanism

α-Arylation of alkylamines with sulfonylarenes through a radical chain mechanism

In the presence of a substoichiometric amount of a tert -butoxy radical precursor, the reaction of alkylamines with sulfonylarenes was found to give α-arylated alkylamines through homolytic aromatic substitution, where a radical chain is operative. A radical chain, conducted by a sulfonyl radical in...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2018-09, Vol.54 (74), p.1471-1474
Hauptverfasser: Ikeda, Yuko, Ueno, Ryota, Akai, Yuto, Shirakawa, Eiji
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Sprache:eng
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Alkylamines
Chains
Substitution reactions
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container_title Chemical communications (Cambridge, England)
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creator Ikeda, Yuko
Ueno, Ryota
Akai, Yuto
Shirakawa, Eiji
description In the presence of a substoichiometric amount of a tert -butoxy radical precursor, the reaction of alkylamines with sulfonylarenes was found to give α-arylated alkylamines through homolytic aromatic substitution, where a radical chain is operative. A radical chain, conducted by a sulfonyl radical in a homolytic aromatic substitution mechanism, makes it possible to promote α-arylation of alkylamines with sulfonylarenes just by using a substoichiometric amount of a tert -butoxy radical precursor.
doi_str_mv 10.1039/c8cc03604g
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source Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects Alkylamines
Chains
Substitution reactions
title α-Arylation of alkylamines with sulfonylarenes through a radical chain mechanism
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