Role of Monocyte Chemoattractant Protein-1 and its Receptor,CCR-2, in the Pathogenesis of Bleomycin-Induced Scleroderma

Systemic sclerosis is a connective tissue disease characterized by excessive deposition of extracellular matrix in the skin as well as various internal organs. Cellular infiltrates are found in the dermis in early systemic sclerosis, which are suggested to play an important part. Recent studies sugg...

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Veröffentlicht in:	Journal of investigative dermatology 2003-09, Vol.121 (3), p.510-516
Hauptverfasser:	Yamamoto, Toshiyuki, Nishioka, Kiyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	animal model Animals Antibiotics, Antineoplastic Antibodies - pharmacology Biological and medical sciences Bleomycin CCR-2 Cells, Cultured Chemokine CCL2 - genetics Chemokine CCL2 - immunology Collagen Type I - genetics Dermis - immunology Dermis - pathology Disease Models, Animal Female Fibroblasts - cytology Fibroblasts - immunology Gene Expression - immunology Medical sciences Mice Mice, Inbred C3H monocyte chemoattractant protein-1 Receptors, CCR2 Receptors, Chemokine - genetics Receptors, Chemokine - immunology RNA, Messenger - analysis Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis scleroderma Scleroderma, Systemic - chemically induced Scleroderma, Systemic - etiology Scleroderma, Systemic - immunology Signal Transduction - immunology Skin Physiological Phenomena - immunology Specific Pathogen-Free Organisms
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